Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural com...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 116; no. 9; pp. 3919 - 3928
Main Authors Kyle, J. E., Burnum-Johnson, K. E., Wendler, J. P., Eisfeld, A. J., Halfmann, Peter J., Watanabe, Tokiko, Sahr, Foday, Smith, R. D., Kawaoka, Y., Waters, K. M., Metz, T. O.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 26.02.2019
SeriesPNAS Plus
Subjects
60 APPLIED LIFE SCIENCES
Adolescent
Adult
Apoptosis
Autophagy
Biological Sciences
Blood plasma
Child
critical illness
Critical Illness - epidemiology
Disease Outbreaks
Ebola
Ebola virus
Ebolavirus
Ebolavirus - genetics
Ebolavirus - pathogenicity
Energy sources
Epidemics
Female
Gene Expression Regulation - genetics
Hemorrhagic Fever, Ebola - blood
Hemorrhagic Fever, Ebola - genetics
Hemorrhagic Fever, Ebola - pathology
Hemorrhagic Fever, Ebola - virology
Humans
Illnesses
Lipid Metabolism - genetics
lipidomics
Lipids
Lipids - blood
Lipids - genetics
Liver
Liver diseases
Male
mass spectrometry
Outbreaks
Phagocytosis
PNAS Plus
Recovery
Sierra Leone - epidemiology
Survival
Target recognition
therapies
Viral diseases
Viremia
Young Adult
Sierra Leone
mass spectrometry
therapies
critical illness
Ebola
lipidomics
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Summary:Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
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PNNL-SA-136689
National Institute of Allergy and Infectious Diseases (NIAID)
Emerging/Re-Emerging Infectious Diseases Project of Japan
National Institutes of Health (NIH)
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Ministry of Education, Culture, Sports, Science and Technology (MEXT)
AC05-76RL01830; 16H06429; 6K21723; 16H06434; U19AI106772; P41 GM103493
Health and Labor Sciences Research
National Institute of General Medical Sciences (NIGMS)
Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 31, 2018 (received for review September 7, 2018)
Author contributions: J.E.K., A.J.E., F.S., R.D.S., Y.K., K.M.W., and T.O.M. designed research; J.E.K., A.J.E., P.J.H., and T.W. performed research; J.E.K., K.E.B.-J., and J.P.W. analyzed data; and J.E.K., A.J.E., K.M.W., and T.O.M. wrote the paper.
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.1815356116