Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural com...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 116; no. 9; pp. 3919 - 3928
Main Authors Kyle, J. E., Burnum-Johnson, K. E., Wendler, J. P., Eisfeld, A. J., Halfmann, Peter J., Watanabe, Tokiko, Sahr, Foday, Smith, R. D., Kawaoka, Y., Waters, K. M., Metz, T. O.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 26.02.2019
SeriesPNAS Plus
Subjects
60 APPLIED LIFE SCIENCES
Adolescent
Adult
Apoptosis
Autophagy
Biological Sciences
Blood plasma
Child
critical illness
Critical Illness - epidemiology
Disease Outbreaks
Ebola
Ebola virus
Ebolavirus
Ebolavirus - genetics
Ebolavirus - pathogenicity
Energy sources
Epidemics
Female
Gene Expression Regulation - genetics
Hemorrhagic Fever, Ebola - blood
Hemorrhagic Fever, Ebola - genetics
Hemorrhagic Fever, Ebola - pathology
Hemorrhagic Fever, Ebola - virology
Humans
Illnesses
Lipid Metabolism - genetics
lipidomics
Lipids
Lipids - blood
Lipids - genetics
Liver
Liver diseases
Male
mass spectrometry
Outbreaks
Phagocytosis
PNAS Plus
Recovery
Sierra Leone - epidemiology
Survival
Target recognition
therapies
Viral diseases
Viremia
Young Adult
Sierra Leone
mass spectrometry
therapies
critical illness
Ebola
lipidomics
Online AccessGet full text
ISSN0027-8424
1091-6490
1091-6490
DOI10.1073/pnas.1815356116

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Abstract Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
AbstractList Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014-2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014-2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. In this work we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
Outbreaks of Ebola virus disease (EVD) continue to emerge with severe and often deadly outcomes and global consequences. Novel strategies for examining host response differences that distinguish EVD survivors and fatalities can only deepen our understanding of the disease and expand diagnostic and treatment options. Lipids are major molecular constituents in human plasma with important structural, transport, energy, and signaling functions. Here we provide a comprehensive examination of the EVD lipidome. Using liquid chromatography tandem mass spectrometry, we profiled the human plasma lipidome of patients that survived and succumbed to EVD during the 2014 outbreak in Sierra Leone. The results highlight the profound impact of EVD on the host lipidome, leading to possible therapies for improving EVD survival. Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.
Author Wendler, J. P.
Metz, T. O.
Kawaoka, Y.
Watanabe, Tokiko
Kyle, J. E.
Eisfeld, A. J.
Waters, K. M.
Halfmann, Peter J.
Smith, R. D.
Burnum-Johnson, K. E.
Sahr, Foday
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30808769$$D View this record in MEDLINE/PubMed
https://www.osti.gov/biblio/1494321$$D View this record in Osti.gov
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Keywords mass spectrometry
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lipidomics
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Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 31, 2018 (received for review September 7, 2018)
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Snippet Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human...
Outbreaks of Ebola virus disease (EVD) continue to emerge with severe and often deadly outcomes and global consequences. Novel strategies for examining host...
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SubjectTerms 60 APPLIED LIFE SCIENCES
Adolescent
Adult
Apoptosis
Autophagy
Biological Sciences
Blood plasma
Child
critical illness
Critical Illness - epidemiology
Disease Outbreaks
Ebola
Ebola virus
Ebolavirus
Ebolavirus - genetics
Ebolavirus - pathogenicity
Energy sources
Epidemics
Female
Gene Expression Regulation - genetics
Hemorrhagic Fever, Ebola - blood
Hemorrhagic Fever, Ebola - genetics
Hemorrhagic Fever, Ebola - pathology
Hemorrhagic Fever, Ebola - virology
Humans
Illnesses
Lipid Metabolism - genetics
lipidomics
Lipids
Lipids - blood
Lipids - genetics
Liver
Liver diseases
Male
mass spectrometry
Outbreaks
Phagocytosis
PNAS Plus
Recovery
Sierra Leone - epidemiology
Survival
Target recognition
therapies
Viral diseases
Viremia
Young Adult
Title Plasma lipidome reveals critical illness and recovery from human Ebola virus disease
URI https://www.jstor.org/stable/26672148
https://www.ncbi.nlm.nih.gov/pubmed/30808769
https://www.proquest.com/docview/2187113127
https://www.proquest.com/docview/2186620323
https://www.osti.gov/biblio/1494321
https://pubmed.ncbi.nlm.nih.gov/PMC6397561
Volume 116
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