Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs

• Published in: Seminars in arthritis and rheumatism Vol. 50; no. 4; pp. 564 - 570
• Main Authors: Michelena, Xabier, Borrell, Helena, López-Corbeto, Mireia, López-Lasanta, María, Moreno, Estefanía, Pascual-Pastor, María, Erra, Alba, Serrat, Mayte, Espartal, Esther, Antón, Susana, Añez, Gustavo Adolfo, Caparrós-Ruiz, Raquel, Pluma, Andrea, Trallero-Araguás, Ernesto, Barceló-Bru, Mireia, Almirall, Miriam, De Agustín, Juan José, Lladós, Jordi, Julià, Antonio, Marsal, Sara
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020
• Subjects: Adolescent; Adult; Aged; Antirheumatic Agents - therapeutic use; Betacoronavirus - drug effects; Biological Products - therapeutic use; Case-Control Studies; Child; Child, Preschool; Coronavirus Infections - diagnosis; Coronavirus Infections - epidemiology; Coronavirus Infections - physiopathology; COVID-19; Cross-Sectional Studies; Epidemiology; Female; Humans; Incidence; Infant; Male; Middle Aged; Pandemics; Pediatric rheumatology; Pneumonia, Viral - diagnosis; Pneumonia, Viral - epidemiology; Pneumonia, Viral - physiopathology; Retrospective Studies; Rheumatic diseases; Rheumatic Diseases - drug therapy; Rheumatic Diseases - epidemiology; SARS-CoV-2; Spain - epidemiology; Targeted disease modifying anti-rheumatic drugs; Young Adult; Spain; COVID-19; Targeted disease modifying anti-rheumatic drugs; Pediatric rheumatology; Epidemiology; Rheumatic diseases
• ISSN: 0049-0172; 1532-866X; 1532-866X
• DOI: 10.1016/j.semarthrit.2020.05.001

•There is limited evidence on the potential risk conferred by tDMARDs with regards to COVID-19 in rheumatic disease patients.•COVID-19 incidence rates are similar to same district general population with no cases reported in the paediatric cohort.•tDMARDs should not be stopped during the pandemic and our findings encourage research with such treatments in COVID-19 disease. To investigate the incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases receiving targeted biologic and synthetic disease modifying anti-rheumatic drugs (tDMARDs) and to explore the possible effect of these treatments in the clinical expression of COVID-19. A cross-sectional study comprising of a telephone survey and electronic health records review was performed including all adult and paediatric patients with rheumatic diseases treated with tDMARDs in a large rheumatology tertiary centre in Barcelona, Spain. Demographics, disease activity, COVID-19 related symptoms and contact history data were obtained from the start of the 2020 pandemic. Cumulative incidence of confirmed cases (SARS-CoV-2 positive PCR test) was compared to the population estimates for the same city districts from a governmental COVID-19 health database. Suspected cases were defined following WHO criteria and compared to those without compatible symptoms. 959 patients with rheumatic diseases treated with tDMARDs were included. We identified 11 confirmed SARS-CoV-2 positive cases in the adult cohort and no confirmed positive cases in the paediatric cohort. COVID-19 incidence rates of the rheumatic patient cohort were very similar to that of the general population [(0.48% (95% CI 0.09 to 0.87%)] and [0.58% (95% CI 0.56 to 0.60%)], respectively. We found significant differences in tDMARDs proportions between the suspected and non-suspected cases (p=0.002). Adult and paediatric patients with rheumatic diseases on tDMARDs do not seem to present a higher risk of COVID-19 or a more severe disease outcome when compared to general population.