Roles of the cerebellum and basal ganglia in temporal integration: Insights from a synchronized tapping task

• Published in: Clinical neurophysiology Vol. 158; pp. 1 - 15
• Main Authors: Tokushige, Shin-ichi, Matsuda, Shunichi, Tada, Masayoshi, Yabe, Ichiro, Takeda, Atsushi, Tanaka, Hiroyasu, Hatakenaka, Megumi, Enomoto, Hiroyuki, Kobayashi, Shunsuke, Shimizu, Kazutaka, Shimizu, Takahiro, Kotsuki, Naoki, Inomata-Terada, Satomi, Furubayashi, Toshiaki, Ichikawa, Yaeko, Hanajima, Ritsuko, Tsuji, Shoji, Ugawa, Yoshikazu, Terao, Yasuo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2024
• Subjects: Basal ganglia; Basal Ganglia - pathology; Cerebellum; Humans; Multiple System Atrophy; Neurology; Spinocerebellar Ataxias - pathology; Spinocerebellar degeneration; Spinocerebellar Degenerations; Synchronized tapping task; Temporal processing; Cerebellum; Temporal processing; Basal ganglia; Spinocerebellar degeneration; Synchronized tapping task
• ISSN: 1388-2457; 1872-8952; 1872-8952
• DOI: 10.1016/j.clinph.2023.11.018

•We compared performances of synchronized tapping task in various subtypes of spinocerebellar ataxia and normal subjects.•Failure to correct the phase and period of tapping reflected dysfunctions of cerebellum and basal ganglia, respectively.•The cerebellum and basal ganglia and their interaction regulate synchronized tapping. The aim of this study was to clarify the roles of the cerebellum and basal ganglia for temporal integration. We studied 39 patients with spinocerebellar degeneration (SCD), comprising spinocerebellar atrophy 6 (SCA6), SCA31, Machado–Joseph disease (MJD, also called SCA3), and multiple system atrophy (MSA). Thirteen normal subjects participated as controls. Participants were instructed to tap on a button in synchrony with isochronous tones. We analyzed the inter-tap interval (ITI), synchronizing tapping error (STE), negative asynchrony, and proportion of delayed tapping as indicators of tapping performance. The ITI coefficient of variation was increased only in MSA patients. The standard variation of STE was larger in SCD patients than in normal subjects, especially for MSA. Negative asynchrony, which is a tendency to tap the button before the tones, was prominent in SCA6 and MSA patients, with possible basal ganglia involvement. SCA31 patients exhibited normal to supranormal performance in terms of the variability of STE, which was surprising. Cerebellar patients generally showed greater STE variability, except for SCA31. The pace of tapping was affected in patients with possible basal ganglia pathology. Our results suggest that interaction between the cerebellum and the basal ganglia is essential for temporal processing. The cerebellum and basal ganglia and their interaction regulate synchronized tapping, resulting in distinct tapping pattern abnormalities among different SCD subtypes.