Introduction of a Rabbit Carotid Artery Model for Sonothrombolysis Research

The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement u...

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Published inTranslational stroke research Vol. 3; no. 3; pp. 397 - 407
Main Authors Hölscher, Thilo, Fisher, David J., Ahadi, Golnaz, Voie, Arne
Format Journal Article
LanguageEnglish
Published New York Springer-Verlag 01.09.2012
Springer Nature B.V
Subjects
Acoustics
Animals
Biomedical and Life Sciences
Biomedicine
Blood clots
Cardiology
Carotid arteries
Ischemia
Neurology
Neurosciences
Neurosurgery
Protocols
Scanning electron microscopy
Surgery
Ultrasonic imaging
Vascular Surgery
Veins & arteries
Transcranial
Rabbit
Stroke
Carotid artery
Sonothrombolysis
High-intensity focused ultrasound
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Summary:The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control. It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.
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ISSN:1868-4483
1868-601X
DOI:10.1007/s12975-012-0194-5