Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case-control study

• Published in: British journal of cancer Vol. 105; no. 11; pp. 1768 - 1771
• Main Authors: Benavente, Y, Mbisa, G, Labo, N, Casabonne, D, Becker, N, Maynadie, M, Foretova, L, Cocco, P L, Nieters, A, Staines, A, Bofetta, P, Brennan, P, Whitby, D, de Sanjosé, S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.11.2011; Nature Publishing Group
• Subjects: 692/420/2780/2152/2153/1291; 692/699/67/1858; 692/699/67/1990/291; 692/699/67/2324; Acquired immune deficiency syndrome; Adolescent; Adult; Aged; Aged, 80 and over; AIDS; Antibodies; Antibodies - immunology; Antigens; Antigens, Viral - immunology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Castleman Disease - immunology; Child; Child, Preschool; Confidence intervals; Dermatology; Drug Resistance; Epidemiology; Europe; Female; Herpes viruses; Herpesvirus; Herpesvirus 8, Human - immunology; HIV; Human immunodeficiency virus; Humans; Immune system; Immunocompetence; Infant; Infant, Newborn; Kaposi's sarcoma-associated herpesvirus; Kaposis sarcoma; Lymphoma; Lymphoma, Non-Hodgkin - immunology; Lymphoma, Non-Hodgkin - virology; Lymphoma, Primary Effusion - immunology; Male; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Oncology; Sarcoma, Kaposi - immunology; Serology; Short Communication; Tumors; Tumors of the skin and soft tissue. Premalignant lesions; Young Adult; Europe; Czech Republic; United States > US; Ireland; Italy; France; Germany; Spain; epidemiology; Kaposi's sarcoma-associated herpes virus; serology; lymphoma; human herpes virus 8; Human; Skin disease; Antibody; Herpes; Malignant hemopathy; Serology; Malignant tumor; Case control study; Lymphoid neoplasm; Epidemiology; Lymphoma; Infection; Virus; Antigen; Associated virus; Kaposi sarcoma; Cancerology; Lymphoproliferative syndrome; Viral disease; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2011.392

Background: Kaposi's sarcoma-associated herpes virus is associated with primary effusion lymphoma and multicentric Castleman's disease. Methods: Seropositivity to lytic and latent Kaposi's sarcoma herpes virus (KSHV) antigens were examined in 2083 lymphomas and 2013 controls from six European countries. Results: Antibodies against KSHV latent and lytic antigens were detectable in 4.5% and 3.4% of controls, respectively, and 3.6% of cases ( P >0.05). The KSHV seropositivity was associated with splenic marginal zone lymphoma (SMZL) (odds ratio (OR)=4.11, 95% confidence interval (CI)=1.57–10.83) and multiple myeloma (OR=0.31, 95% CI=0.11–0.85). Conclusion: The KSHV is unlikely to contribute importantly to lymphomagenesis among immunocompetent subjects. However, the observed association with SMZL may underline a chronic antigen mechanism in its aetiology.