Microwave-Based Microfluidic Sensor for Non-Destructive and Quantitative Glucose Monitoring in Aqueous Solution

• Published in: Sensors (Basel, Switzerland) Vol. 16; no. 10; p. 1733
• Main Authors: Chretiennot, Thomas, Dubuc, David, Grenier, Katia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.10.2016; MDPI
• Subjects: Aqueous solutions; Biosensors; Diabetes; Electric fields; Electrodes; Electromagnetism; Engineering Sciences; Glucose; Glucose - analysis; Glucose monitoring; glycaemia; Humans; Lab-on-a-chip; microfluidic; Microfluidics; Microfluidics - methods; microwave; Microwaves; Miniature; Monitoring; Quantitative analysis; sensor; Sensors; Thin films; Water - chemistry; glucose; sensor; microfluidic; glycaemia; microwave
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s16101733

This paper presents a reliable microwave and microfluidic miniature sensor dedicated to the measurement of glucose concentration in aqueous solution. The device; which is integrated with microtechnologies; is made of a bandstop filter implemented in a thin film microstrip technology combined with a fluidic microchannel. Glucose aqueous solutions have been characterized for concentration ranging from 80 g/L down to 0.3 g/L and are identified with the normalized insertion loss at optimal frequency. The sensitivity of the sensor has consequently been estimated at 7.6 × 10 dB/(g/L); together with the experimental uncertainty; the resolution of the sensor comes to 0.4 g/L. These results demonstrate the potentialities of such a sensor for the quantitative analysis of glucose in aqueous solution.