Amino Acid Derivatives of Adamantane Carbocycle are Capable of Inhibiting Replication of Highly Virulent Avian Influenza A/H5N1 Virus

• Published in: Bulletin of experimental biology and medicine Vol. 157; no. 1; pp. 62 - 65
• Main Authors: Deryabin, P. G., Garaev, T. M., Finogenova, M. P., Botikov, A. G., Shibnev, V. A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2014; Springer; Springer Nature B.V
• Subjects: Adamantane - analogs & derivatives; Adamantane - chemical synthesis; Adamantane - pharmacology; Animals; Antiviral Agents - chemical synthesis; Antiviral Agents - pharmacology; Avian influenza; Avian influenza viruses; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Line; Embryo, Mammalian; Epithelial Cells - cytology; Epithelial Cells - drug effects; Epithelial Cells - virology; Health aspects; Histidine; Histidine - chemistry; Humans; Infection; Influenza A Virus, H5N1 Subtype - drug effects; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza A Virus, H5N1 Subtype - physiology; Internal Medicine; Kidney - cytology; Kidney - drug effects; Kidney - virology; Laboratory Medicine; Pathology; Rimantadine - pharmacology; Serine - chemistry; Swine; Virology; Virulence; Virulence (Microbiology); Virus diseases; Virus Replication - drug effects; influenza virus; A/H5N; adamantane derivatives; resistance; amino acids
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-014-2492-2

We studied the capacity amino acid derivatives of adamantane to inhibit replication of highly virulent avian influenza A/duck/Novosibirsk/56/05 (H5N1) virus in cultures of swine embryonic kidney cells. Amino acid derivatives of adamantane H-His-Rem and Ad(CH 2 -Ser-OMe) 2 were characterized by lower toxicity than remantadine previously used in the treatment of influenza. Histidine-containing adamantane derivative (H-His-Rem) was the most effective and low-toxic inhibitor of influenza А/H5N1 virus replication and can be recommended for clinical trials to produce a preparation for the treatment and prevention of influenza.