Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects

• Published in: Metabolism, clinical and experimental Vol. 61; no. 2; pp. 250 - 254
• Main Authors: Barosa, Cristina, Silva, Claudia, Fagulha, Ana, Barros, Luísa, Caldeira, M. Madalena, Carvalheiro, Manuela, Jones, John G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2012; Elsevier
• Subjects: acetaminophen; Adult; Animals; Biological and medical sciences; body water; breakfast; Carbon Isotopes - pharmacokinetics; deuterium; Deuterium Oxide - pharmacokinetics; Eating - physiology; Endocrinology & Metabolism; Feeding. Feeding behavior; Female; Fructosephosphates - metabolism; Fundamental and applied biological sciences. Psychology; galactose; glucose; Glucose - metabolism; Glucose - pharmacokinetics; glucose 6-phosphate; Glucose-6-Phosphate - metabolism; Glucuronides - metabolism; glycogen; glycogenesis; Health; Humans; Liver Glycogen - biosynthesis; Liver Glycogen - metabolism; Male; menthol; metabolites; Milk - metabolism; Milk - physiology; nuclear magnetic resonance spectroscopy; Tissue Distribution; tracer techniques; uridine diphosphate; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Breakfast; Healthy subject; Digestive system; Glycogen; Liver; Meal; Endocrinology; Milk

During feeding, dietary galactose is a potential source of hepatic glycogen synthesis; but its contribution has not been measured to date. In the presence of deuterated water ( 2H 2O), uridine diphosphate (UDP)–glucose derived from galactose is not enriched, whereas the remainder derived from glucos...