Role of the Stria Vascularis in the Pathogenesis of Sensorineural Hearing Loss: A Narrative Review

Sensorineural hearing loss is a common sensory impairment in humans caused by abnormalities in the inner ear. The stria vascularis is regarded as a major cochlear structure that can independently degenerate and influence the degree of hearing loss. This review summarizes the current literature on th...

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Published inFrontiers in neuroscience Vol. 15; p. 774585
Main Authors Yu, Wenting, Zong, Shimin, Du, Peiyu, Zhou, Peng, Li, Hejie, Wang, Enhao, Xiao, Hongjun
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 19.11.2021
Frontiers Media S.A
Subjects
Acidosis
cell signaling
Cochlea
Drugs
Hearing loss
Hearing protection
Homeostasis
Inner ear
Kinases
molecular factors
Mutation
Neuroscience
Pathogenesis
Potassium
Proteins
RNA polymerase
sensorineural hearing loss
Stria vascularis
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Summary:Sensorineural hearing loss is a common sensory impairment in humans caused by abnormalities in the inner ear. The stria vascularis is regarded as a major cochlear structure that can independently degenerate and influence the degree of hearing loss. This review summarizes the current literature on the role of the stria vascularis in the pathogenesis of sensorineural hearing loss resulting from different etiologies, focusing on both molecular events and signaling pathways, and further attempts to explore the underlying mechanisms at the cellular and molecular biological levels. In addition, the deficiencies and limitations of this field are discussed. With the rapid progress in scientific technology, new opportunities are arising to fully understand the role of the stria vascularis in the pathogenesis of sensorineural hearing loss, which, in the future, will hopefully lead to the prevention, early diagnosis, and improved treatment of sensorineural hearing loss.
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Edited by: Hua Feng, Southwest Hospital, Army Medical University, China
This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
These authors have contributed equally to this work
Reviewed by: Brian McKinnon, University of Texas Medical Branch at Galveston, United States; Ophir Handzel, Tel Aviv Sourasky Medical Center, Israel
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2021.774585