TETRAZOMINE, A NEW ANTIBIOTIC PRODUCED BY AN ACTINOMYCETE STRAIN TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

A new antibacterial antibiotic tetrazomine was found from the fermentation broth of an actinomycete strain which was isolated from beach sand collected at Chichijima, Ogasawara Islands, Tokyo, Japan. The strain Y-09194L, was identified as Saccharothrix mutabilis subsp. chichijimaensis subsp. nov. Th...

Full description

Saved in:
Bibliographic Details
Published inJournal of antibiotics Vol. 44; no. 5; pp. 479 - 485
Main Authors SUZUKI, KENICHI, SATO, TSUTOMU, MORIOKA, MOTO, NAGAI, KOJI, ABE, KENJI, YAMAGUCHI, HIROSHI, SAITO, TAKESHI, OHMI, YUKIO, SUSAKI, KIYOSHI
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991
Japan Antibiotics Research Association
Subjects
Actinomycetales - analysis
Actinomycetales - cytology
Actinomycetales - metabolism
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Fermentation
Leukemia L1210 - drug therapy
Leukemia P388 - drug therapy
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Piperidines - isolation & purification
Piperidines - pharmacology
Antineoplastic agent
Taxonomy
Leukemia
Cytotoxicity
Malignant hemopathy
Fermentation
In vitro
L1210 cell line
Antibiotic
Cell line
Microbial origin
Production
Bacteria
Isolation
Actinomycetes
Tumor cell
Physicochemical properties
Online AccessGet full text

Cover

More Information
Summary:A new antibacterial antibiotic tetrazomine was found from the fermentation broth of an actinomycete strain which was isolated from beach sand collected at Chichijima, Ogasawara Islands, Tokyo, Japan. The strain Y-09194L, was identified as Saccharothrix mutabilis subsp. chichijimaensis subsp. nov. The antibiotic exhibited broad antimicrobial activity against Gram-positive and Gram-negative bacteria in vitro. It also exhibited strong cytotoxic activity against P388 leukemia cells and showed antitumor activity against P388 leukemia. The apparent molecular formula of tetrazomine was determined as C24H34N4O5. It has a rare structure which consists of six rings including piperidine, piperadine, oxazole, and pyrrolidine.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.479