Hypoxia: a barricade to conquer the pancreatic cancer

Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading...

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Published inCellular and molecular life sciences : CMLS Vol. 77; no. 16; pp. 3077 - 3083
Main Authors Tan, Zhen, Xu, Jin, Zhang, Bo, Shi, Si, Yu, Xianjun, Liang, Chen
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.08.2020
Springer Nature B.V
Subjects
Adenosine triphosphate
Angiogenesis
Antineoplastic Agents - therapeutic use
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer therapies
Cell adhesion & migration
Cell Biology
Cell Hypoxia - drug effects
Cell Hypoxia - physiology
Chemical compounds
Chemotherapy
Dehydrogenases
Disease Progression
drug therapy
Extracellular matrix
Fibroblasts
Genes
Glucose
Humans
Hypoxia
Kinases
Life Sciences
Malignancy
Metastases
Metastasis
Microenvironments
MicroRNAs
Mortality
Pancreatic cancer
pancreatic neoplasms
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - pathology
Pharmacology
Phosphorylation
Proteins
Radiation therapy
radiotherapy
Review
Survival
survival rate
Transcription factors
Tumor Microenvironment - physiology
Tumors
Vascular endothelial growth factor
Hypoxia-inducible factors
Chemoresistant
Tumor malignant behavior
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Summary:Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.
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ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-019-03444-3