New advances in genitourinary cancer: evidence gathered in 2014

This review provides updated information published in 2014 regarding advances and major achievements in genitourinary cancer. Sections include the best in prostate cancer, renal cancer, bladder cancer, and germ cell tumors. In the field of prostate cancer, data related to treatment approach of hormo...

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Published inCancer and metastasis reviews Vol. 34; no. 3; pp. 443 - 464
Main Authors Suárez, C., Puente, J., Gallardo, E., Méndez-Vidal, M. J., Climent, M. A., León, L., Olmos, D., García del Muro, X., González-Billalabeitia, E., Grande, E., Bellmunt, J., Mellado, B., Maroto, P., González del Alba, A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.09.2015
Springer
Springer Nature B.V
Subjects
Antimitotic agents
Antineoplastic agents
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Care and treatment
Clinical
Development and progression
Humans
Metastasis
Oncology
Oncology, Experimental
Prostate cancer
Urogenital Neoplasms - therapy
Zoledronic acid
Molecular research
Genitourinary cancer
Renal cancer
Bladder cancer
Prostate cancer
Germ cell tumors
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Summary:This review provides updated information published in 2014 regarding advances and major achievements in genitourinary cancer. Sections include the best in prostate cancer, renal cancer, bladder cancer, and germ cell tumors. In the field of prostate cancer, data related to treatment approach of hormone-sensitive disease, castrate-resistant prostate cancer, mechanisms of resistance, new drugs, and molecular research are presented. In relation to renal cancer, relevant aspects in the treatment of advanced renal cell carcinoma, immunotherapy, and molecular research, including angiogenesis and von Hippel-Lindau gene, molecular biology of non-clear cell histologies, and epigenetics of clear renal cell cancer are described. New strategies in the management of muscle-invasive localized bladder cancer and metastatic disease are reported as well as salient findings of biomolecular research in urothelial cancer. Some approaches intended to improve outcomes in poor prognosis patients with metastatic germ cell cancer are also reported. Results of clinical trials in these areas are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0167-7659
1573-7233
DOI:10.1007/s10555-015-9577-x