Body composition following stem cell transplant: Comparison of bioimpedance and air-displacement plethysmography

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 30; no. 9; pp. 1000 - 1006
• Main Authors: Hung, Yun-Chi, BHlth.Sci, Bauer, Judith D., Ph.D, Horsely, Pamela, Grad.Dip.Dietetics, Ward, Leigh C., Ph.D, Bashford, John, R.A.C.P, Isenring, Elisabeth A., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2014; Elsevier; Elsevier Limited
• Subjects: Absorptiometry, Photon; Adipose Tissue; Adult; Aged; Agreements; Air; Air-displacement plethysmography; Bioelectrical impedance; Biological and medical sciences; Body Composition; Body Fluid Compartments; Body Mass Index; Calibration; Cancer; Children & youth; Electric Impedance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Hematopoietic Stem Cells; Humans; Male; Medical sciences; Middle Aged; Mortality; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms - therapy; Plethysmography - methods; Quality of life; Software; Spectroscopy; Spectrum analysis; Stem Cell Transplantation; Stem cells; Studies; Transplantation; Tumors; Values; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Australia; Stem cell transplantation; Spectroscopy; Air-displacement plethysmography; Body composition; Bioelectrical impedance; Cancer; Nutrition; Stem cell; Transplantation; Malignant tumor; Air plethysmography; Impedance; Comparative study
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2014.01.017

Abstract Objective The aim of this study was to assess the agreement between detected changes in body composition determined by bioimpedance spectroscopy (BIS) and air-displacement plethysmography (ADP) among patients with cancer undergoing peripheral blood stem cell transplantation (PBSCT); and to assess the agreement of absolute values of BIS with ADP and dual energy x-ray (DXA). Methods Forty-four adult hematologic cancer patients undergoing PBSCT completed both BIS and ADP assessment at preadmission and at 3 mo after transplantation. A subsample (n = 11) was assessed by DXA at 3 mo after transplantation. Results were examined for the BIS instrument’s default setting and three alternative predictive equations from the literature. Agreement was assessed by the Bland-Altman limits of agreement analysis while correlation was examined using the Lin’s concordance correlation. Results Changes in body composition parameters assessed by BIS were comparable with those determined by ADP regardless of the predictive equations used. Bias of change in fat-free mass was clinically acceptable (all <1 kg), although limits of agreement were wide (more than ±6 kg). Overall, the BIS predictive equation accounting for body mass index performed the best. Absolute body composition parameters predicted by the alternative predictive equations agreed with DXA and ADP better than the BIS instrument’s default setting. Conclusion Changes predicted by BIS were similar to those determined by ADP on a group level; however, agreement of predicted changes at an individual level should be interpreted with caution due to wide limits of agreement.