New tuberculosis drugs on the horizon

Highlights ► Tuberculosis is a global health concern owing to the emergence of MDR and XDR strains of M. tuberculosis . ► In the past, efforts were made to discover new leads for TB drug development using target-based and cell-based approaches. ► The most promising anti-tubercular candidates are des...

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Bibliographic Details
Published inCurrent opinion in microbiology Vol. 14; no. 5; pp. 570 - 576
Main Authors Cole, Stewart T, Riccardi, Giovanna
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.10.2011
Elsevier
Subjects
Antitubercular Agents - chemistry
Antitubercular Agents - isolation & purification
Antitubercular Agents - pharmacology
Biological and medical sciences
biosynthesis
cell walls
Clinical Trials as Topic
Drug Discovery - trends
drugs
Fundamental and applied biological sciences. Psychology
Human immunodeficiency virus
Humans
Microbiology
multiple drug resistance
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
nitroaromatic compounds
Pathology
Research - trends
tuberculosis
Tuberculosis - drug therapy
Tuberculosis - microbiology
Review
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Summary:Highlights ► Tuberculosis is a global health concern owing to the emergence of MDR and XDR strains of M. tuberculosis . ► In the past, efforts were made to discover new leads for TB drug development using target-based and cell-based approaches. ► The most promising anti-tubercular candidates are described and compounds that inhibit a new target are introduced.
Bibliography:http://dx.doi.org/10.1016/j.mib.2011.07.022
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ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2011.07.022