Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis

• Published in: The Journal of pediatrics Vol. 167; no. 5; pp. 1074 - 1080.e2
• Main Authors: Kusumi, Kirsten, Smith, Sally, Barr-Beare, Evan, Saxena, Vijay, Schober, Megan S., Moore-Clingenpeel, Melissa, Schwaderer, Andrew L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2015
• Subjects: Adolescent; Atherosclerosis - diagnosis; Atherosclerosis - etiology; Atherosclerosis - metabolism; Biomarkers - metabolism; Carotid Intima-Media Thickness; Child; Enzyme-Linked Immunosorbent Assay; Female; Fibronectins - metabolism; Humans; Male; Nephrolithiasis - complications; Nephrolithiasis - diagnosis; Nephrolithiasis - metabolism; Osteopontin - metabolism; Pediatrics; Retrospective Studies; Risk Factors; Scavenger Receptors, Class A - metabolism; Vascular Cell Adhesion Molecule-1 - metabolism; MSR1; cIMT; VCAM1; FN1; OPN; BMI; ELISA; Macrophage scavenger receptor 1; Osteopontin; Carotid artery intima-media thickness; Fibronectin; Body mass index; Vascular cell adhesion protein 1; Enzyme-linked immunosorbent assay
• ISSN: 0022-3476; 1097-6833; 1097-6833
• DOI: 10.1016/j.jpeds.2015.08.014

To determine if nephrolithiasis-associated atherosclerosis has pediatric origins and to consider possible association between kidney stones and atherosclerosis-related proteins. We matched children aged 12-17 years with kidney stones and without kidney stones. Carotid artery intima-media thickness (cIMT) was measured by ultrasound. Participants' urine was investigated by enzyme-linked immunosorbent assay for the atherosclerosis-related proteins fibronectin 1, macrophage scavenger receptor 1, osteopontin, and vascular cell adhesion molecule 1 levels, and normalized to urine creatinine levels. Subjects with nephrolithiasis had higher cIMT in the right common carotid artery and overall mean measurement. Urine osteopontin and fibronectin 1 were significant predictors of cIMT. We have provided initial preliminary evidence that nephrolithiasis-associated atherosclerosis has pediatric origins and performed studies that begin to identify potential reasons for the association of nephrolithiasis and vascular disease.