The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis

The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epi...

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Published inCancer microenvironment Vol. 5; no. 1; pp. 5 - 18
Main Authors Heinrich, Eileen L., Walser, Tonya C., Krysan, Kostyantyn, Liclican, Elvira L., Grant, Jeanette L., Rodriguez, Nicole L., Dubinett, Steven M.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.04.2012
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Biology
Immunology
Oncology
Original Paper
NSCLC
E-cadherin
Inflammation
Online AccessGet full text

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Abstract The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.
AbstractList The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.
The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.[PUBLICATION ABSTRACT]
Author Krysan, Kostyantyn
Dubinett, Steven M.
Heinrich, Eileen L.
Grant, Jeanette L.
Liclican, Elvira L.
Walser, Tonya C.
Rodriguez, Nicole L.
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  organization: Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Department of Medicine, David Geffen School of Medicine at UCLA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, The Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center
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Issue 1
Keywords NSCLC
E-cadherin
Inflammation
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PublicationSubtitle Official Journal of the International Cancer Microenvironment Society
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Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Biology
Immunology
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Title The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis
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