The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis

The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epi...

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Bibliographic Details
Published inCancer microenvironment Vol. 5; no. 1; pp. 5 - 18
Main Authors Heinrich, Eileen L., Walser, Tonya C., Krysan, Kostyantyn, Liclican, Elvira L., Grant, Jeanette L., Rodriguez, Nicole L., Dubinett, Steven M.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.04.2012
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Biology
Immunology
Oncology
Original Paper
NSCLC
E-cadherin
Inflammation
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Summary:The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.
ISSN:1875-2292
1875-2284
DOI:10.1007/s12307-011-0089-0