Rhabdomyosarcoma infiltrating bone marrow

We present a case of 26-year-old male, previously diagnosed as rhabdomyosarcoma (RMS) of perineal region. The peripheral smear showed a leukoerythroblastic picture with an occasional atypical cell. The bone marrow aspirate and biopsy showed monotonous sheets of malignant cells. On immunohistochemist...

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Bibliographic Details
Published inInternational journal of hematology Vol. 101; no. 1; pp. 1 - 2
Main Authors Chauhan, Kriti, Jain, Monica, Shukla, Pragya, Grover, R. K.
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.01.2015
Springer Nature B.V
Subjects
Adult
Biopsy
Bone Marrow - metabolism
Bone Marrow - pathology
Fatal Outcome
Hematology
Humans
Images in Hematology
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Neoplasm Invasiveness
Oncology
Rhabdomyosarcoma - diagnosis
Rhabdomyosarcoma - pathology
Rhabdomyosarcoma - therapy
Jugular Foramen
Perineal Region
Acute Leukemia
Peripheral Smear
Rhabdomyosarcoma
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Summary:We present a case of 26-year-old male, previously diagnosed as rhabdomyosarcoma (RMS) of perineal region. The peripheral smear showed a leukoerythroblastic picture with an occasional atypical cell. The bone marrow aspirate and biopsy showed monotonous sheets of malignant cells. On immunohistochemistry the tumor cells were strongly positive for desmin and negative for CD34 and CD117. This case illustrates the morphology and IHC findings in a case of RMS. Immunostains like CD34 and CD117 should be included to rule out a possibility of acute leukemia.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-014-1692-x