Neuromodulatory effects of high-definition theta transcranial alternating current stimulation on the parietal cortex: a pilot study of healthy males

• Published in: Frontiers in Neuroscience Vol. 17; p. 1255124
• Main Authors: Chen, Xixi, Wu, Yuwei, Shi, Xiaolong, Zhou, Zhiqing, Feng, Tingyi, Ren, Meng, Li, Yuanli, Shan, Chunlei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 09.11.2023; Frontiers Research Foundation; Frontiers Media S.A
• Subjects: Attention; Brain; Cholinergic transmission; Cognition & reasoning; Cognitive ability; Cortex (parietal); EEG; Electrodes; Electroencephalography; Entropy; Excitability; Hemispheric laterality; Information processing; Latency; Memory; Neural networks; Neuroscience; Neurosciences. Biological psychiatry. Neuropsychiatry; nonlinear dynamics analysis; parietal cortex; RC321-571; Sensory neurons; short latency afferent inhibition; Theta rhythms; transcranial alternating current stimulation; Transcranial magnetic stimulation; United States > US; China; short latency afferent inhibition; parietal cortex; transcranial alternating current stimulation; nonlinear dynamics analysis; EEG
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2023.1255124

Transcranial alternating current stimulation (tACS) can regulate brain functions by modulating endogenous brain rhythms. Theta-band neural oscillations are associated with memory function. In particular, theta neural oscillatory power evoked in the parietal cortex is closely related to memory retrieval processes. In this study, the immediate effects of high-definition theta transcranial alternating current stimulation (HDθ-tACS) on the human left parietal cortex were investigated using short-latency afferent inhibition (SAI) and electroencephalography (EEG). Ten subjects participated in this study. We used 6-Hz HD tACS to stimulate the left parietal cortex for 15 min. SAI was calculated, and non-linear dynamic analysis of the EEG was performed to analyze neuronal function after HD θ-tACS. The results showed a significant decrease in SAI ( < 0.05), while the left frontoparietal network was reinforced, leading to brain lateralization after HD θ-tACS. During performance of a memory task, F3 signals showed a significant upward trend in approximate entropy following treatment ( < 0.05). There was also a significant decrease in cross-approximate entropy in the C3-C4 and P3-P4 connections following the intervention ( < 0.05) in a resting eyes-open condition and in the memory task condition. In conclusion, HD θ-tACS could alter cholinergic transmission and cortical excitability between the parietal and motor cortices, as well as reinforcing the frontoparietal network and the left-lateralization phenomenon, which may facilitate memory formation, encoding, and consolidation.