Focusing on mitochondria in the brain: from biology to therapeutics

Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the brain is particularly prominent. The brain demands...

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Published inTranslational neurodegeneration Vol. 13; no. 1; p. 23
Main Authors Song, Nanshan, Mei, Shuyuan, Wang, Xiangxu, Hu, Gang, Lu, Ming
Format Journal Article
LanguageEnglish
Published England BioMed Central 17.04.2024
BMC
Subjects
Brain
Mitochondria
Mitochondrial transfer
Neurological disorders
Review
Brain
Mitochondrial transfer
Mitochondria
Neurological disorders
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Summary:Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the brain is particularly prominent. The brain demands 20% of the resting metabolic rate and holds highly active mitochondrial activities. Considerable research shows that mitochondria are closely related to brain function, while mitochondrial defects induce or exacerbate pathology in the brain. In this review, we provide comprehensive research advances of mitochondrial biology involved in brain functions, as well as the mitochondria-dependent cellular events in brain physiology and pathology. Furthermore, various perspectives are explored to better identify the mitochondrial roles in neurological diseases and the neurophenotypes of mitochondrial diseases. Finally, mitochondrial therapies are discussed. Mitochondrial-targeting therapeutics are showing great potentials in the treatment of brain diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2047-9158
2047-9158
DOI:10.1186/s40035-024-00409-w