Nulliparity, decade of first birth, and breast cancer in Connecticut cohorts, 1855 to 1945: an ecological study

Risk of breast cancer increases with age at first birth, and is lower in women who bear their first children while young than in nulliparous women. While previous studies have investigated risk of breast cancer in birth cohorts by examining partial aspects of cohort childbearing, the present ecologi...

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Published inAmerican journal of public health (1971) Vol. 79; no. 11; pp. 1503 - 1507
Main Authors Hahn, R A, Moolgavkar, S H
Format Journal Article
LanguageEnglish
Published Washington, DC Am Public Health Assoc 01.11.1989
American Public Health Association
Subjects
Biological and medical sciences
Births
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Breasts
Cancer
Cohort Studies
Connecticut
Ecological studies
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Maternal Age
Medical sciences
Parity
Risk Factors
Tumors
Women
Connecticut
Human
United States
Malignant tumor
North America
Gestational age
Pregnancy
Follow up study
America
Connecticut
Risk factor
Evolution
Female
Nulliparity
Tumor
Mammary gland
Parity
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Summary:Risk of breast cancer increases with age at first birth, and is lower in women who bear their first children while young than in nulliparous women. While previous studies have investigated risk of breast cancer in birth cohorts by examining partial aspects of cohort childbearing, the present ecological study assesses total cohort childbearing risk in Connecticut women born between 1855 and 1945. In each cohort, the proportion of women nulliparous and first bearing children in their twenties, thirties, and forties are weighted by relative risks associated with these events as ascertained in previous studies. Summed cohort childbearing risks are compared to the incidence of breast cancer in women 40 years of age and older in the same cohorts. Changes in decade of first birth and nulliparity do not explain the changes in breast cancer incidence observed: while cohort childbearing risk has declined over the period examined, breast cancer incidence has increased in the same cohorts. Alternative explanations for cohort increases in breast cancer incidence are reviewed.
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ISSN:0090-0036
1541-0048
DOI:10.2105/AJPH.79.11.1503