Systemic therapy for brain metastases

Metastases from cells outside of the central nervous system are the most common cancer found in the brain and are commonly associated with poor prognosis. Although cancer treatment is improving overall, central nervous system metastases are becoming more prevalent and require finesse to properly tre...

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Published inCritical reviews in oncology/hematology Vol. 142; pp. 44 - 50
Main Authors Rick, Jonathan W, Shahin, Maryam, Chandra, Ankush, Dalle Ore, Cecilia, Yue, John K., Nguyen, Alan, Yagnik, Garima, Sagar, Soumya, Arfaie, Saman, Aghi, Manish K.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2019
Subjects
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Breast cancer
Breast Neoplasms - secondary
Breast Neoplasms - therapy
Humans
Lung cancer
Lung Neoplasms - secondary
Lung Neoplasms - therapy
Melanoma
Melanoma - secondary
Melanoma - therapy
Metastasis
Systemic therapy
Systemic therapy
Breast cancer
Metastasis
Lung cancer
Melanoma
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Summary:Metastases from cells outside of the central nervous system are the most common cancer found in the brain and are commonly associated with poor prognosis. Although cancer treatment is improving overall, central nervous system metastases are becoming more prevalent and require finesse to properly treat. Physicians must consider the biology of the primary tumor and the complex neurological environment that the metastasis resides in. This can be further complicated by the fact that the practice of cancer management is constantly evolving and therapy that works outside of the blood-brain barrier may not be effective inside of it. Therefore, this review seeks to update the reader on recent advancements made on the three most common sources of brain metastases: lung cancer, breast cancer, and melanoma. Each of these malignancies has been the subject of intriguing and novel avenues of therapy which are reviewed here.
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Author declaration
We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us. We confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property. We understand that the Corresponding Author is the sole contact for the Editorial process (including Editorial Manager and direct communications with the office). He/she is responsible for communicating with the other authors about progress, submissions of revisions and final approval of proofs. We confirm that we have provided a current, correct email address which is accessible by the Corresponding Author and which has been configured to accept email
ISSN:1040-8428
1879-0461
1879-0461
DOI:10.1016/j.critrevonc.2019.07.012