Lung cancer: What are the links with oxidative stress, physical activity and nutrition

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 82; no. 3; pp. 383 - 389
• Main Authors: Filaire, Edith, Dupuis, Carmen, Galvaing, Géraud, Aubreton, Sylvie, Laurent, Hélène, Richard, Ruddy, Filaire, Marc
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ireland Ltd 01.12.2013; Elsevier
• Subjects: Animals; Antioxidants - therapeutic use; Biological and medical sciences; Carcinogenesis; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - prevention & control; Cognitive science; Hematology, Oncology and Palliative Medicine; Humans; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - prevention & control; Medical sciences; Micronutrients - therapeutic use; Motor Activity; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neuroscience; Nutrition; Nutritional Physiological Phenomena; Oxidative Stress; Physical activity; Pneumology; Psychology; Pulmonary/Respiratory; Quality of life; Respiratory function; Risk; Smoking; Tumors; Tumors of the respiratory system and mediastinum; Oxidative stress; Respiratory function; Physical activity; Nutrition; Lung cancer; Quality of life; Physical exercise; Human; Lung disease; Respiratory disease; Malignant tumor; Feeding; Lung function; Bronchus disease; Cancer
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2013.09.009

Abstract Oxidative stress appears to play an essential role as a secondary messenger in the normal regulation of a variety of physiological processes, such as apoptosis, survival, and proliferative signaling pathways. Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world. Lung cancer is the commonest fatal cancer whose risk is dependent on the number of cigarettes smoked per day as well as the number of years smoking, some components of cigarette smoke inducing oxidative stress by transmitting or generating oxidative stress. It can be subdivided into two broad categories, small cell lung cancer and non-small-cell lung cancer, the latter is the most common type. Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects. However, physical activity can have different influences on carcinogenesis, depending on energy supply, strength and frequency of exercise loads as well as the degree of exercise-mediated oxidative stress. Micronutrient supplementation seems to have a positive impact in lung surgery, particularly as an antioxidant, even if the role of micronutrients in lung cancer remains controversial. The purpose of this review is to examine lung cancer in relation to oxidative stress, physical activity, and nutrition.