The cytokine network involved in the host immune response to periodontitis

Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveol...

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Published inInternational journal of oral science Vol. 11; no. 3; pp. 30 - 13
Main Authors Pan, Weiyi, Wang, Qingxuan, Chen, Qianming
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 05.11.2019
Springer Nature B.V
Subjects
631/80/304
692/699/3020/3029
Alveolar bone
Alveolar Bone Loss - etiology
Bone loss
Cytokines
Cytokines - metabolism
Cytokines - physiology
Dentistry
Dysbacteriosis
Gum disease
Humans
Immune response
Inflammation
Inflammatory diseases
Medicine
Oral and Maxillofacial Surgery
Oral cavity
Orthopedics
Osteoclasts
Periodontal Diseases
Periodontitis
Periodontitis - immunology
Periodontitis - microbiology
Review
Review Article
Surgical Orthopedics
Tumor Necrosis Factor-alpha - physiology
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Abstract Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
AbstractList Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
ArticleNumber 30
Author Pan, Weiyi
Wang, Qingxuan
Chen, Qianming
Author_xml – sequence: 1
  givenname: Weiyi
  surname: Pan
  fullname: Pan, Weiyi
  organization: State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University
– sequence: 2
  givenname: Qingxuan
  surname: Wang
  fullname: Wang, Qingxuan
  organization: State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University
– sequence: 3
  givenname: Qianming
  surname: Chen
  fullname: Chen, Qianming
  email: qmchen@scu.edu.cn
  organization: State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31685798$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0968-0004(03)00067-7
10.1091/mbc.E14-12-1645
10.1016/j.immuni.2015.12.003
10.1128/IAI.06276-11
10.1111/jre.12235
10.1038/338225a0
10.1177/0022034510397838
10.4049/jimmunol.179.4.2359
10.1016/j.immuni.2019.03.011
10.1111/jre.12100
10.1620/tjem.243.159
10.1016/0092-8674(95)90070-5
10.1158/2326-6066.CIR-17-0498
10.1038/nrmicro2337
10.1016/j.cyto.2016.08.027
10.1038/nrcardio.2010.120
10.1038/ni.3632
10.1038/s41467-018-05940-9
10.1136/ard.2007.083360
10.1111/odi.12983
10.1126/science.7973658
10.1016/j.immuni.2013.01.004
10.1038/nrmicro2873
10.1111/jre.12241
10.1902/jop.2010.100425
10.1111/jcpe.13060
10.1002/art.22175
10.1016/j.immuni.2019.03.018
10.1084/jem.172.3.921
10.1016/j.cyto.2015.08.001
10.1371/journal.pbio.2000080
10.1111/imr.12621
10.1046/j.0303-6979.2003.00435.x
10.1006/cyto.1997.0208
10.1186/ar1857
10.1016/j.immuni.2013.06.018
10.1073/pnas.0902745106
10.1016/S0092-8674(03)00521-X
10.1016/0960-9822(93)90009-D
10.1073/pnas.87.18.6934
10.1189/jlb.1012543
10.1111/jre.12131
10.1111/j.1601-0825.2008.01497.x
10.1038/nature04753
10.1016/j.immuni.2019.03.028
10.1084/jem.191.2.275
10.1016/j.jaut.2012.03.003
10.1038/ni1254
10.1101/gad.1360605
10.1038/mi.2016.47
10.1038/ni1537
10.4049/jimmunol.0804165
10.1038/nri3908
10.1016/j.immuni.2019.03.024
10.1016/S1074-7613(02)00324-2
10.1902/jop.2009.090015
10.1038/mi.2015.136
10.5005/jp-journals-10024-2372
10.1902/jop.2000.71.4.573
10.1016/j.chom.2017.06.014
10.1111/jcpe.12082
10.1016/j.immuni.2019.03.012
10.1038/ni.1791
10.1111/j.1399-302X.2007.00408.x
10.1002/cre2.162
10.1093/emboj/16.19.5894
10.1016/j.micinf.2012.03.002
10.4049/jimmunol.168.11.5699
10.1016/j.it.2013.09.001
10.1371/journal.pone.0152794
10.1161/01.STR.30.10.2174
10.1038/ni.3103
10.1126/scisignal.aaa5157
10.1016/j.archoralbio.2014.04.007
10.1073/pnas.72.9.3666
10.4049/jimmunol.177.1.36
10.1146/annurev-immunol-031210-101312
10.1016/j.it.2017.08.005
10.1155/2019/6034546
10.1038/ni.2416
10.1126/science.1200439
10.1111/jre.12339
10.1016/S1074-7613(03)00298-X
10.1902/jop.2015.140520
10.1016/j.molmed.2019.02.010
10.1902/jop.2008.080183
10.1111/prd.12181
10.1074/jbc.M109.017129
10.2220/biomedres.38.189
10.1152/ajpgi.00329.2010
10.1111/j.1399-302X.2007.00360.x
10.1177/154411130201300104
10.1038/ni1539
10.1146/annurev-immunol-032713-120257
10.1016/S1074-7613(01)00243-6
10.1046/j.0303-6979.2003.00425.x
10.1111/prd.12083
10.1111/jcpe.12286
10.1016/j.cyto.2012.05.016
10.1111/jcpe.12803
10.1038/nri3707
10.1902/jop.2008.070616
10.12703/P6-31
10.1016/j.immuni.2019.03.017
10.1177/0022034515577815
10.1016/j.chom.2013.04.005
10.1016/j.chom.2016.10.001
10.1126/scitranslmed.aat0797
10.1084/jem.174.5.1209
10.1902/jop.2005.76.5.785
10.1016/j.archoralbio.2014.08.021
10.1097/MIB.0000000000001274
10.1126/science.3336774
10.1016/S1074-7613(00)80252-6
10.1111/prd.12002
10.1038/s41590-018-0249-1
10.1038/nrrheum.2017.56
10.1038/35085597
10.1038/nri1001
10.1126/scitranslmed.3009124
10.1038/ni.2260
10.1111/jcpe.12279
10.3389/fimmu.2016.00479
10.1016/j.molcel.2006.03.026
10.1172/JCI6910
10.1016/j.cell.2011.09.044
10.3892/etm.2014.1724
10.1126/science.1411569
10.1038/cmi.2015.105
10.1126/science.181845
10.1189/jlb.0108014
10.4049/jimmunol.0901528
10.1111/odi.12598
10.1155/2012/174764
10.1126/scitranslmed.aac5380
10.2334/josnusd.51.261
10.1902/jop.2016.150713
10.1038/ni1439
10.4049/jimmunol.166.8.4915
10.1111/jcpe.12557
10.3389/fimmu.2014.00511
10.1016/j.immuni.2011.03.018
10.1016/j.archoralbio.2015.06.018
10.1016/S1074-7613(00)00070-4
10.2353/ajpath.2006.060180
10.1902/jop.2012.120009
10.1038/ni.1767
10.1016/j.jebdp.2018.04.001
10.1084/jem.20041257
10.1902/jop.2012.110585
10.1038/nrrheum.2010.139
10.1902/jop.2012.120225
10.4049/jimmunol.180.5.2752
10.1016/S1074-7613(03)00296-6
10.1016/j.cell.2008.03.036
10.1172/JCI5703
10.1016/j.immuni.2019.03.021
10.1177/0022034510375281
10.1902/jop.2014.140293
10.1038/nrrheum.2015.171
10.1007/s00011-013-0669-1
10.1371/journal.pone.0168080
10.1620/tjem.232.215
10.1590/S0103-64402012000400020
10.1074/jbc.M513118200
10.1902/jop.2011.110239
10.1177/0022034512446341
10.1074/jbc.M600620200
10.1038/sj.bjp.0706979
10.1038/nri3785
10.1038/ismej.2012.174
10.1016/j.chom.2011.10.006
10.1177/0022034518805739
10.1038/nrendo.2011.106
10.1016/j.cyto.2008.11.005
10.1155/2013/181849
10.1902/jop.2017.170244
10.1038/ni.2227
10.1038/ni.2027
10.1111/j.1600-051X.2009.01390.x
10.1111/j.1601-0825.2011.01798.x
10.1016/j.cell.2011.11.031
10.1128/MCB.18.7.4109
10.1038/ni1540
10.1016/j.cyto.2014.05.024
10.1016/j.cell.2011.08.050
10.1177/154405910508400711
10.1177/0022034519847443
10.1101/cshperspect.a000158
10.1016/j.coi.2018.09.002
10.1016/j.molcel.2004.08.008
10.1016/j.immuni.2019.03.027
10.1038/ni0507-448
10.1016/0092-8674(88)90486-2
10.1111/j.1600-051X.2008.01212.x
10.1146/annurev-immunol-032713-120225
10.1177/0022034510376402
10.1038/385729a0
10.1016/j.molcel.2009.10.013
10.1146/annurev.immunol.021908.132612
10.1038/378088a0
10.1016/j.jaci.2018.03.019
10.1084/jem.162.5.1726
10.1111/j.0105-2896.2006.00375.x
10.1177/154405910808700908
10.1126/science.1631559
10.1042/bj20030407
10.1038/nri3834
10.1111/j.1600-051X.1998.tb02419.x
10.1034/j.1600-051x.2002.290208.x
10.4049/jimmunol.172.9.5149
10.1021/acsnano.7b08976
10.1111/j.2041-1014.2011.00612.x
10.1016/1074-7613(95)90070-5
10.1111/jcpe.13065
10.1016/j.immuni.2019.03.026
10.1038/nrd3030
10.1089/gtmb.2014.0275
10.1111/jre.12078
10.1126/science.1109745
10.1159/000465455
10.1038/43219
10.4049/jimmunol.1200131
10.1902/jop.2009.080447
10.4049/jimmunol.146.10.3444
10.4049/jimmunol.136.7.2478
10.1111/odi.13003
10.1016/S0021-9258(18)89560-6
10.4049/jimmunol.155.12.5483
10.1016/S0021-9258(17)43716-1
10.4103/0972-124X.183098
10.1016/S0021-9258(18)71533-0
10.1128/CDLI.11.1.106-110.2004
10.1016/S0021-9258(18)89559-X
10.1128/JVI.70.2.1143-1153.1996
10.4049/jimmunol.147.11.3815
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PublicationDecade 2010
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PublicationPlace_xml – name: London
– name: India
PublicationTitle International journal of oral science
PublicationTitleAbbrev Int J Oral Sci
PublicationTitleAlternate Int J Oral Sci
PublicationYear 2019
Publisher Nature Publishing Group UK
Springer Nature B.V
Publisher_xml – name: Nature Publishing Group UK
– name: Springer Nature B.V
References Niedbala (CR221) 2008; 67
Mayer, Elimelech, Balbir‐Gurman, Braun‐Moscovici, Machtei (CR243) 2013; 84
Pan (CR86) 2019; 46
Mantovani, Dinarello, Molgora, Garlanda (CR32) 2019; 50
Kohanski (CR166) 2018; 142
Nakajima (CR208) 2005; 84
Kanayama (CR109) 2004; 15
Pers, Saraux, Pierre, Youinou (CR241) 2008; 79
Liu (CR168) 2009; 2
Sasaoka (CR222) 2010; 300
Bazan (CR144) 1990; 87
Polak, Shapira (CR128) 2018; 45
Okamura (CR52) 1995; 378
Osta, Benedetti, Miossec (CR120) 2014; 5
Le Gros, Ben-Sasson, Seder, Finkelman, Paul (CR147) 1990; 172
Gowen, Mundy (CR140) 1986; 136
Ranganathan, Gracey, Brown, Inman, Haroon (CR237) 2017; 13
Liu (CR247) 2018; 12
Pan (CR85) 2019; 46
Walsh, Choi (CR119) 2014; 5
Ay (CR214) 2012; 83
Papathanasiou (CR47) 2014; 49
Nair, Bandyopadhyay, Kundu, Das (CR58) 2016; 20
Ortiz (CR244) 2009; 80
Black (CR96) 1997; 385
Trepicchio (CR212) 1999; 104
Okui, Aoki, Ito, Honda, Yamazaki (CR179) 2012; 91
Aggarwal, Henzel, Moffat, Kohr, Harkins (CR91) 1985; 260
Lalla, Papapanou (CR7) 2011; 7
Jones, Maerz, Buckner (CR65) 2018; 55
Horwood, Elliott, Martin, Gillespie (CR141) 2001; 166
Wang (CR108) 2001; 412
Kitaura (CR118) 2013; 2013
Trinchieri, Pflanz, Kastelein (CR136) 2003; 19
Hajishengallis (CR16) 2011; 10
Zhu (CR161) 2012; 60
Hamano (CR219) 2003; 19
Kawai (CR125) 2006; 169
Rickert, Wang, Boulanger, Goriatcheva, Garcia (CR146) 2005; 308
Dinarello (CR33) 2009; 27
Li, Kobayashi, Blonska, You, Lin (CR103) 2006; 281
Mayer, Balbir‐Gurman, Machtei (CR242) 2009; 80
Kotenko (CR197) 1997; 16
Fujihara (CR124) 2014; 49
Fokkema (CR137) 2003; 30
Shim (CR110) 2005; 19
De Benedetti (CR83) 2006; 54
Dutzan, Konkel, Greenwell-Wild, Moutsopoulos (CR209) 2016; 9
Di Paola (CR246) 2007; 150
Johnson, Serio (CR139) 2005; 76
Gilowski, Wiench, Płocica, Krzemiński (CR39) 2014; 59
McGeachy (CR159) 2007; 8
Bazan (CR132) 1993; 3
Floss (CR133) 2016; 27
Coomes (CR199) 2017; 10
Ceccarelli (CR129) 2019; 2019
Kebschull, Demmer, Papapanou (CR6) 2010; 89
Fitzgerald (CR226) 2007; 8
Hajishengallis (CR1) 2015; 15
Friedrich, Pohin, Powrie (CR236) 2019; 50
Stumhofer (CR225) 2007; 8
Ay, Sütçü, Uskun, Bozkurt, Berker (CR215) 2009; 15
Genco, Van Dyke (CR5) 2010; 7
Hajishengallis (CR19) 2014; 35
Cardoso (CR205) 2008; 84
Lundberg, Wegner, Yucel-Lindberg, Venables (CR8) 2010; 6
Wang, Du, Wang (CR112) 2008; 133
Basso (CR126) 2016; 87
Kang, Tanaka, Narazaki, Kishimoto (CR68) 2019; 50
Chaudhry (CR200) 2011; 34
Beale (CR165) 2014; 6
Yao (CR153) 1995; 155
Tseng (CR104) 2018; 101
Zekeridou, Mombelli, Cancela, Courvoisier, Giannopoulou (CR89) 2019; 24
Codarri (CR223) 2011; 12
Moutsopoulos (CR160) 2012; 39
Köseoğlu, Hatipoğlu, Sağlam, Enhoş, Esen (CR50) 2015; 50
Collison (CR67) 2012; 13
Malefyt, Abrams, Bennett, Figdor, De Vries (CR198) 1991; 174
Dutzan, Gamonal, Silva, Sanz, Vernal (CR206) 2009; 36
Kotake (CR155) 1999; 103
Dinarello (CR34) 2018; 281
Madianos, Bobetsis, Offenbacher (CR9) 2013; 40
Li, Li, Sun, Jin, Wu (CR23) 2014; 63
Trinchieri (CR134) 2003; 3
Lavu (CR35) 2015; 19
Ouyang, Rutz, Crellin, Valdez, Hymowitz (CR196) 2011; 29
Nold-Petry (CR231) 2015; 16
Parham (CR157) 2002; 168
Murakami, Kamimura, Hirano (CR66) 2019; 50
Kobayashi (CR116) 2000; 191
Darveau (CR13) 2010; 8
Yücel, Berker, Gariboğlu, Otlu (CR216) 2008; 35
Martuscelli, Fiorellini, Crohin, Howell (CR27) 2000; 71
Duhen, Geiger, Jarrossay, Lanzavecchia, Sallusto (CR78) 2009; 10
Jones, Stuart, Walker (CR98) 1989; 338
Alayan (CR25) 2007; 22
Zhu (CR80) 2016; 2016
Murai (CR203) 2009; 10
Qian (CR169) 2007; 8
Loesche (CR10) 1992; 19
Kourtzelis (CR184) 2019; 20
Oates, Graves, Cochran (CR245) 2002; 29
Eskan (CR26) 2012; 13
Langrish (CR37) 2005; 201
Conti (CR176) 2016; 20
Pflanz (CR218) 2002; 16
Trompouki (CR193) 2011; 147
Hamedi (CR59) 2009; 45
Ding, Ji, Chen, Xu, Zhong (CR22) 2014; 41
Lorenzen, Dingley, Jacques, Grötzinger (CR145) 2006; 281
Andrukhov (CR190) 2011; 82
Figueredo (CR53) 2008; 23
Sharma, Khattak, Naagtilak, Singh, Bano (CR138) 2014; 8
Naka (CR72) 1997; 387
Wu, Zhou, Huang, Yingchen, Kang (CR84) 2017; 41
Santos‐Lima (CR87) 2019; 1
Sánchez‐Hernández (CR55) 2011; 17
Jones (CR76) 2010; 184
Moutsopoulos, Konkel (CR28) 2018; 39
Young (CR224) 2012; 189
Hasegawa (CR64) 2016; 7
Fiorentino (CR202) 1991; 146
Sarhan (CR232) 2018; 6
Mills, Dungan, Jones, Harris (CR38) 2013; 93
Abusleme, Moutsopoulos (CR175) 2017; 23
Morgan, Ruscetti, Gallo (CR186) 1976; 193
Campos, Fischer, Gustafsson, Figueredo (CR56) 2012; 23
Tada (CR48) 2016; 11
Abusleme (CR18) 2013; 7
Boukortt (CR21) 2015; 60
Özçaka, Nalbantsoy, Buduneli (CR54) 2011; 46
Wolf, Rose-John, Garbers (CR74) 2014; 70
Brenner, Blaser, Mak (CR94) 2015; 15
Haas (CR105) 2009; 36
Gemmell, Yamazaki, Seymour (CR151) 2002; 13
Graves (CR20) 2008; 79
Travis, Sheppard (CR192) 2014; 32
Wang, Guan, Wei, Yan (CR61) 2019; 19
Fantini (CR195) 2004; 172
Hsu, Xiong, Goeddel (CR100) 1995; 81
Sasaki (CR142) 2004; 11
Xiao (CR181) 2017; 22
Tanaka (CR24) 2017; 243
Zenobia, Hajishengallis (CR178) 2015; 69
Kriegler, Perez, DeFay, Albert, Lu (CR95) 1988; 53
Hajishengallis, Korostoff (CR3) 2017; 75
Holt, Ebersole, Felton, Brunsvold, Kornman (CR11) 1988; 239
Vivar, Van Vollenhoven (CR240) 2014; 6
Zhou (CR88) 2019; 25
Wojno, Hunter, Stumhofer (CR130) 2019; 50
Aggarwal (CR92) 1985; 260
Yao (CR152) 1995; 3
Kishimoto, Akira, Taga (CR70) 1992; 258
Liao, Lin, Leonard (CR189) 2013; 38
Harrington (CR156) 2005; 6
Karlsen, Borregaard, Cowland (CR170) 2010; 285
McInnes, Buckley, Isaacs (CR235) 2016; 12
Hoffmann, Baltimore (CR107) 2006; 210
Wan (CR210) 2015; 76
McLean (CR220) 2017; 23
Aggarwal, Moffat, Harkins (CR93) 1984; 259
Lambrecht, Hammad, Fahy (CR239) 2019; 50
Murphy (CR115) 2013; 39
Orth, O’Brien‐Simpson, Dashper, Reynolds (CR14) 2011; 26
Teitelbaum (CR117) 2005; 8
Fort (CR164) 2001; 15
García‐Hernández (CR41) 2019; 25
Gaffen, Jain, Garg, Cua (CR173) 2014; 14
Faustman, Davis (CR99) 2010; 9
Reis (CR40) 2014; 8
Devergne (CR217) 1996; 70
Malcolm (CR51) 2015; 94
CR63
Heinrich (CR71) 2003; 374
Algate, Haynes, Bartold, Crotti, Cantley (CR121) 2016; 51
Takahashi-Tezuka (CR73) 1998; 18
Hajishengallis, Darveau, Curtis (CR30) 2012; 10
Carswell (CR90) 1975; 72
Jia-Jia (CR230) 2013; 22
McGeachy, Cua, Gaffen (CR163) 2019; 50
Toy (CR171) 2006; 177
Patel, Kuchroo (CR174) 2015; 43
Himani, Prabhuji, Karthikeyan (CR162) 2014; 49
Hsu, Huang, Shu, Baichwal, Goeddel (CR101) 1996; 4
Kostulas, Pelidou, Kivisäkk, Kostulas, Link (CR154) 1999; 30
Arancibia (CR127) 2013; 84
Lee (CR158) 2012; 13
Oppmann (CR131) 2000; 13
Shin (CR185) 2015; 7
Batlle, Massagué (CR191) 2019; 50
Shaker, Ghallab (CR213) 2012; 2012
Isaza‐Guzmán, Medina‐Piedrahíta, Gutiérrez‐Henao, Tobón‐Arroyave (CR42) 2017; 88
Sun (CR114) 2012; 148
Leonard, Lin, O’Shea (CR143) 2019; 50
Kobayashi (CR207) 2011; 90
Jing (CR233) 2019; 98
CR2
Stadler (CR81) 2016; 43
Socransky, Haffajee, Cugini, Smith, Kent (CR12) 1998; 25
Hajishengallis, Chavakis (CR183) 2019; 25
Lapérine (CR43) 2016; 11
Tada (CR49) 2017; 38
Eke (CR4) 2015; 86
Israël (CR106) 2010; 2
Gaffen, Hajishengallis (CR31) 2008; 87
Glimcher (CR135) 2007; 8
Ben-Sasson (CR36) 2009; 106
Yoshinaka (CR62) 2014; 232
Puel (CR177) 2011; 332
Hajishengallis, Shakhatreh, Wang, Liang (CR113) 2007; 179
Dutzan (CR180) 2018; 10
Russell (CR188) 1994; 266
Sonis (CR211) 1997; 9
Fiorentino, Zlotnik, Mosmann, Howard, O’Garra (CR201) 1991; 147
Kurşunlu, Öztürk, Han, Atmaca, Emingil (CR46) 2015; 60
Jiao (CR17) 2013; 13
Batten (CR227) 2008; 180
Park-Min (CR204) 2009; 183
Offenbacher (CR234) 2018; 9
Górska (CR123) 2003; 30
Lowes, Suarez-Farinas, Krueger (CR238) 2014; 32
Settem, El-Hassan, Honma, Stafford, Sharma (CR15) 2012; 80
Eck, Sprang (CR97) 1989; 264
Micheau, Tschopp (CR111) 2003; 114
Vestweber (CR182) 2015; 15
Vitetta (CR148) 1985; 162
Takeshita (CR187) 1992; 257
Pradeep, Hadge, Chowdhry, Patel, Happy (CR57) 2009; 51
Heink (CR77) 2017; 18
Bettelli (CR79) 2006; 441
Garlet (CR150) 2010; 89
Mitani (CR228) 2015; 86
Graves, Corrêa, Silva (CR29) 2019; 98
Ea, Deng, Xia, Pineda, Chen (CR102) 2006; 22
Riethmueller (CR69) 2017; 15
Ebersole (CR82) 2014; 41
Sağlam (CR44) 2015; 50
Madureira (CR122) 2018; 18
Song, He, Li, Qian (CR172) 2016; 13
Buduneli, Özçaka, Nalbantsoy (CR45) 2012; 83
Reddy, Guenther, DeKoter, Young (CR194) 2011; 147
Cekici, Kantarci, Hasturk, Van Dyke (CR149) 2014; 64
Lin (CR75) 2015; 8
Novatchkova, Leibbrandt, Werzowa, Neubüser, Eisenhaber (CR167) 2003; 28
Yee, Kim, Alpagot, Düzgüneş, Konopka (CR60) 2012; 14
Babaloo, Rahbar, Babaloo, Ghasemi, Amini (CR229) 2018; 19
MH McLean (64_CR220) 2017; 23
MA Travis (64_CR192) 2014; 32
SF Kurşunlu (64_CR46) 2015; 60
DF Fiorentino (64_CR201) 1991; 147
HR Conti (64_CR176) 2016; 20
O Devergne (64_CR217) 1996; 70
RP Darveau (64_CR13) 2010; 8
S Offenbacher (64_CR234) 2018; 9
EY Jones (64_CR98) 1989; 338
ÖÖ Yücel (64_CR216) 2008; 35
O Lapérine (64_CR43) 2016; 11
F Ceccarelli (64_CR129) 2019; 2019
J Zhu (64_CR80) 2016; 2016
SC Holt (64_CR11) 1988; 239
AR Pradeep (64_CR57) 2009; 51
M Batten (64_CR227) 2008; 180
C Ding (64_CR22) 2014; 41
N Dutzan (64_CR209) 2016; 9
RA Black (64_CR96) 1997; 385
H Sasaki (64_CR142) 2004; 11
MJ McGeachy (64_CR159) 2007; 8
RDW Malefyt (64_CR198) 1991; 174
MA Kohanski (64_CR166) 2018; 142
BN Lambrecht (64_CR239) 2019; 50
DA Morgan (64_CR186) 1976; 193
CA Dinarello (64_CR34) 2018; 281
C Wang (64_CR108) 2001; 412
TL Haas (64_CR105) 2009; 36
P Sánchez‐Hernández (64_CR55) 2011; 17
T Duhen (64_CR78) 2009; 10
K Kobayashi (64_CR116) 2000; 191
J Beale (64_CR165) 2014; 6
JS Stumhofer (64_CR225) 2007; 8
ZG Li (64_CR23) 2014; 63
MC Fantini (64_CR195) 2004; 172
W-Y Tseng (64_CR104) 2018; 101
DM Isaza‐Guzmán (64_CR42) 2017; 88
V Nair (64_CR58) 2016; 20
Q Wu (64_CR84) 2017; 41
G Trinchieri (64_CR134) 2003; 3
M Takahashi-Tezuka (64_CR73) 1998; 18
LN Zhou (64_CR88) 2019; 25
H Jia-Jia (64_CR230) 2013; 22
J Wolf (64_CR74) 2014; 70
LE Harrington (64_CR156) 2005; 6
I Lorenzen (64_CR145) 2006; 281
PN Madianos (64_CR9) 2013; 40
WJ Leonard (64_CR143) 2019; 50
MA Eskan (64_CR26) 2012; 13
LH Glimcher (64_CR135) 2007; 8
M Kriegler (64_CR95) 1988; 53
L Abusleme (64_CR175) 2017; 23
ES Vitetta (64_CR148) 1985; 162
R Fujihara (64_CR124) 2014; 49
CR Cardoso (64_CR205) 2008; 84
G Hajishengallis (64_CR1) 2015; 15
R Arancibia (64_CR127) 2013; 84
N Kostulas (64_CR154) 1999; 30
G Hajishengallis (64_CR183) 2019; 25
D Faustman (64_CR99) 2010; 9
DM Floss (64_CR133) 2016; 27
JL Ebersole (64_CR82) 2014; 41
JR Karlsen (64_CR170) 2010; 285
F De Benedetti (64_CR83) 2006; 54
S Riethmueller (64_CR69) 2017; 15
G Hajishengallis (64_CR16) 2011; 10
S Sonis (64_CR211) 1997; 9
A Zekeridou (64_CR89) 2019; 24
SJ Fokkema (64_CR137) 2003; 30
T Takeshita (64_CR187) 1992; 257
H Hasegawa (64_CR64) 2016; 7
A Hoffmann (64_CR107) 2006; 210
Y Lee (64_CR158) 2012; 13
WL Trepicchio (64_CR212) 1999; 104
B Oppmann (64_CR131) 2000; 13
L Sun (64_CR114) 2012; 148
Z Yao (64_CR153) 1995; 155
N Vivar (64_CR240) 2014; 6
J Alayan (64_CR25) 2007; 22
CL Langrish (64_CR37) 2005; 201
JF Bazan (64_CR132) 1993; 3
R Johnson (64_CR139) 2005; 76
RJ Genco (64_CR5) 2010; 7
J Malcolm (64_CR51) 2015; 94
L Wang (64_CR112) 2008; 133
N Dutzan (64_CR206) 2009; 36
W Pan (64_CR86) 2019; 46
M Murai (64_CR203) 2009; 10
D Toy (64_CR171) 2006; 177
W Liao (64_CR189) 2013; 38
P Ortiz (64_CR244) 2009; 80
NM Moutsopoulos (64_CR28) 2018; 39
B Osta (64_CR120) 2014; 5
C Zenobia (64_CR178) 2015; 69
H Li (64_CR103) 2006; 281
L Gilowski (64_CR39) 2014; 59
Ö Özçaka (64_CR54) 2011; 46
I Kourtzelis (64_CR184) 2019; 20
AM Kebschull (64_CR6) 2010; 89
Z Yao (64_CR152) 1995; 3
Y Mayer (64_CR242) 2009; 80
JF Bazan (64_CR144) 1990; 87
A Cekici (64_CR149) 2014; 64
L Zhu (64_CR161) 2012; 60
G Hajishengallis (64_CR30) 2012; 10
Y Qian (64_CR169) 2007; 8
CA Dinarello (64_CR33) 2009; 27
64_CR63
G Hajishengallis (64_CR19) 2014; 35
DC Fitzgerald (64_CR226) 2007; 8
X Song (64_CR172) 2016; 13
KN Boukortt (64_CR21) 2015; 60
MA Lowes (64_CR238) 2014; 32
Y Jiao (64_CR17) 2013; 13
M Sağlam (64_CR44) 2015; 50
K Algate (64_CR121) 2016; 51
OG Shaker (64_CR213) 2012; 2012
WJ Loesche (64_CR10) 1992; 19
H Hsu (64_CR100) 1995; 81
PI Eke (64_CR4) 2015; 86
B Wan (64_CR210) 2015; 76
D Vestweber (64_CR182) 2015; 15
M Friedrich (64_CR236) 2019; 50
C-K Ea (64_CR102) 2006; 22
R Kobayashi (64_CR207) 2011; 90
A Babaloo (64_CR229) 2018; 19
CM Figueredo (64_CR53) 2008; 23
M Gowen (64_CR140) 1986; 136
LW Collison (64_CR67) 2012; 13
G Hajishengallis (64_CR3) 2017; 75
T Kishimoto (64_CR70) 1992; 258
A Sharma (64_CR138) 2014; 8
WW Lin (64_CR75) 2015; 8
G Hajishengallis (64_CR113) 2007; 179
GW Jones (64_CR76) 2010; 184
N Dutzan (64_CR180) 2018; 10
T Oates (64_CR245) 2002; 29
K Tanaka (64_CR24) 2017; 243
H Okamura (64_CR52) 1995; 378
S Köseoğlu (64_CR50) 2015; 50
A Young (64_CR224) 2012; 189
D Graves (64_CR20) 2008; 79
D Brenner (64_CR94) 2015; 15
L Jing (64_CR233) 2019; 98
N Buduneli (64_CR45) 2012; 83
S Hamano (64_CR219) 2003; 19
V Lavu (64_CR35) 2015; 19
SZ Ben-Sasson (64_CR36) 2009; 106
A Puel (64_CR177) 2011; 332
BB Aggarwal (64_CR91) 1985; 260
G Trinchieri (64_CR136) 2003; 19
GS Himani (64_CR162) 2014; 49
K-H Park-Min (64_CR204) 2009; 183
S Kang (64_CR68) 2019; 50
DD Patel (64_CR174) 2015; 43
E Xiao (64_CR181) 2017; 22
E Lalla (64_CR7) 2011; 7
AF Stadler (64_CR81) 2016; 43
BB Aggarwal (64_CR93) 1984; 259
SV Kotenko (64_CR197) 1997; 16
MJ McGeachy (64_CR163) 2019; 50
S Heink (64_CR77) 2017; 18
T Nakajima (64_CR208) 2005; 84
E Bettelli (64_CR79) 2006; 441
G Martuscelli (64_CR27) 2000; 71
H Tada (64_CR49) 2017; 38
A Mantovani (64_CR32) 2019; 50
SL Gaffen (64_CR31) 2008; 87
S Kotake (64_CR155) 1999; 103
BE Jones (64_CR65) 2018; 55
D Sarhan (64_CR232) 2018; 6
D Polak (64_CR128) 2018; 45
G Le Gros (64_CR147) 1990; 172
ZY Ay (64_CR214) 2012; 83
A Mitani (64_CR228) 2015; 86
E Trompouki (64_CR193) 2011; 147
K Yoshinaka (64_CR62) 2014; 232
JM Murphy (64_CR115) 2013; 39
DT Graves (64_CR29) 2019; 98
H Hsu (64_CR101) 1996; 4
M Novatchkova (64_CR167) 2003; 28
C Parham (64_CR157) 2002; 168
F Wang (64_CR61) 2019; 19
RH Orth (64_CR14) 2011; 26
64_CR2
M Hamedi (64_CR59) 2009; 45
EKN Santos‐Lima (64_CR87) 2019; 1
E Gemmell (64_CR151) 2002; 13
SM Russell (64_CR188) 1994; 266
M Yee (64_CR60) 2012; 14
PC Heinrich (64_CR71) 2003; 374
W Pan (64_CR85) 2019; 46
MC Walsh (64_CR119) 2014; 5
BB Aggarwal (64_CR92) 1985; 260
C Liu (64_CR168) 2009; 2
W Ouyang (64_CR196) 2011; 29
A Chaudhry (64_CR200) 2011; 34
JO Pers (64_CR241) 2008; 79
MM Fort (64_CR164) 2001; 15
J-H Shim (64_CR110) 2005; 19
Y Mayer (64_CR243) 2013; 84
SL Gaffen (64_CR173) 2014; 14
IB McInnes (64_CR235) 2016; 12
V Ranganathan (64_CR237) 2017; 13
Z Liu (64_CR247) 2018; 12
T Kawai (64_CR125) 2006; 169
RP Settem (64_CR15) 2012; 80
R Górska (64_CR123) 2003; 30
O Micheau (64_CR111) 2003; 114
H Kitaura (64_CR118) 2013; 2013
J Shin (64_CR185) 2015; 7
AL García‐Hernández (64_CR41) 2019; 25
DF Madureira (64_CR122) 2018; 18
J Reddy (64_CR194) 2011; 147
C Reis (64_CR40) 2014; 8
T Naka (64_CR72) 1997; 387
T Okui (64_CR179) 2012; 91
CA Nold-Petry (64_CR231) 2015; 16
H Tada (64_CR48) 2016; 11
L Abusleme (64_CR18) 2013; 7
KH Mills (64_CR38) 2013; 93
BO Campos (64_CR56) 2012; 23
R Di Paola (64_CR246) 2007; 150
E Papathanasiou (64_CR47) 2014; 49
E Batlle (64_CR191) 2019; 50
GP Garlet (64_CR150) 2010; 89
O Andrukhov (64_CR190) 2011; 82
MJ Eck (64_CR97) 1989; 264
A Israël (64_CR106) 2010; 2
NM Moutsopoulos (64_CR160) 2012; 39
S Pflanz (64_CR218) 2002; 16
M Rickert (64_CR146) 2005; 308
L Codarri (64_CR223) 2011; 12
DF Fiorentino (64_CR202) 1991; 146
EDT Wojno (64_CR130) 2019; 50
K Lundberg (64_CR8) 2010; 6
NJ Horwood (64_CR141) 2001; 166
M Murakami (64_CR66) 2019; 50
ZY Ay (64_CR215) 2009; 15
FG Basso (64_CR126) 2016; 87
W Niedbala (64_CR221) 2008; 67
T Sasaoka (64_CR222) 2010; 300
EA Carswell (64_CR90) 1975; 72
SS Socransky (64_CR12) 1998; 25
SM Coomes (64_CR199) 2017; 10
SL Teitelbaum (64_CR117) 2005; 8
A Kanayama (64_CR109) 2004; 15
References_xml – volume: 28
  start-page: 226
  year: 2003
  end-page: 229
  ident: CR167
  article-title: The STIR-domain superfamily in signal transduction, development and immunity
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/S0968-0004(03)00067-7
– volume: 27
  start-page: 2301
  year: 2016
  end-page: 2316
  ident: CR133
  article-title: Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E14-12-1645
– volume: 43
  start-page: 1040
  year: 2015
  end-page: 1051
  ident: CR174
  article-title: Th17 cell pathway in human immunity: lessons from genetics and therapeutic interventions
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.12.003
– volume: 80
  start-page: 2436
  year: 2012
  end-page: 2443
  ident: CR15
  article-title: and induce synergistic alveolar bone loss in a mouse periodontitis model
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.06276-11
– volume: 50
  start-page: 525
  year: 2015
  end-page: 534
  ident: CR50
  article-title: Interleukin‐33 could play an important role in the pathogenesis of periodontitis
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12235
– volume: 338
  start-page: 225
  year: 1989
  end-page: 228
  ident: CR98
  article-title: Structure of tumour necrosis factor
  publication-title: Nature
  doi: 10.1038/338225a0
– volume: 90
  start-page: 653
  year: 2011
  end-page: 658
  ident: CR207
  article-title: Induction of IL-10-producing CD4+ T-cells in chronic periodontitis
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034510397838
– volume: 179
  start-page: 2359
  year: 2007
  end-page: 2367
  ident: CR113
  article-title: Complement receptor 3 blockade promotes IL-12-mediated clearance of and negates its virulence
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.4.2359
– volume: 50
  start-page: 851
  year: 2019
  end-page: 870
  ident: CR130
  article-title: The immunobiology of the interleukin-12 family: room for discovery
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.011
– volume: 49
  start-page: 237
  year: 2014
  end-page: 245
  ident: CR162
  article-title: Gingival crevicular fluid and interleukin‐23 concentration in systemically healthy subjects: their relationship in periodontal health and disease
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12100
– volume: 155
  start-page: 5483
  year: 1995
  end-page: 5486
  ident: CR153
  article-title: Human IL-17: a novel cytokine derived from T cells
  publication-title: J. Immunol.
– volume: 243
  start-page: 159
  year: 2017
  end-page: 164
  ident: CR24
  article-title: The IL18 promoter polymorphism, rs1946518, is associated with the risk of periodontitis in Japanese women: the Kyushu Okinawa maternal and child health study
  publication-title: Tohoku J. Exp. Med.
  doi: 10.1620/tjem.243.159
– volume: 81
  start-page: 495
  year: 1995
  end-page: 504
  ident: CR100
  article-title: The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90070-5
– volume: 6
  start-page: 766
  year: 2018
  end-page: 775
  ident: CR232
  article-title: Adaptive NK cells resist regulatory T-cell suppression driven by IL37
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-17-0498
– volume: 8
  start-page: 481
  year: 2010
  end-page: 490
  ident: CR13
  article-title: Periodontitis: a polymicrobial disruption of host homeostasis
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2337
– volume: 101
  start-page: 19
  year: 2018
  end-page: 25
  ident: CR104
  article-title: TNFR signalling and its clinical implications
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2016.08.027
– volume: 11
  start-page: 106
  year: 2004
  end-page: 110
  ident: CR142
  article-title: Gamma interferon (IFN-γ) and IFN-γ-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo
  publication-title: Clin. Diagn. Lab. Immunol.
– volume: 7
  start-page: 479
  year: 2010
  end-page: 480
  ident: CR5
  article-title: Prevention: reducing the risk of CVD in patients with periodontitis
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/nrcardio.2010.120
– volume: 18
  start-page: 74
  year: 2017
  end-page: 85
  ident: CR77
  article-title: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T 17 cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3632
– volume: 9
  year: 2018
  ident: CR234
  article-title: GWAS for interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05940-9
– volume: 67
  start-page: 1474
  year: 2008
  end-page: 1479
  ident: CR221
  article-title: Interleukin 27 attenuates collagen-induced arthritis
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/ard.2007.083360
– volume: 25
  start-page: 265
  year: 2019
  end-page: 273
  ident: CR88
  article-title: Macrophage polarization in human gingival tissue in response to periodontal disease
  publication-title: Oral. Dis.
  doi: 10.1111/odi.12983
– volume: 266
  start-page: 1042
  year: 1994
  end-page: 1045
  ident: CR188
  article-title: Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID
  publication-title: Science
  doi: 10.1126/science.7973658
– volume: 38
  start-page: 13
  year: 2013
  end-page: 25
  ident: CR189
  article-title: Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.01.004
– volume: 10
  start-page: 717
  year: 2012
  end-page: 725
  ident: CR30
  article-title: The keystone-pathogen hypothesis
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2873
– volume: 8
  start-page: ZC90
  year: 2014
  end-page: ZC92
  ident: CR138
  article-title: Effect of periodontal therapy on salivary interleukin-12 levels in chronic periodontitis
  publication-title: J. Clin. Diagn. Res.
– volume: 50
  start-page: 614
  year: 2015
  end-page: 621
  ident: CR44
  article-title: Levels of interleukin‐37 in gingival crevicular fluid, saliva, or plasma in periodontal disease
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12241
– volume: 82
  start-page: 885
  year: 2011
  end-page: 892
  ident: CR190
  article-title: Serum cytokine levels in periodontitis patients in relation to the bacterial load
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2010.100425
– volume: 46
  start-page: 286
  year: 2019
  end-page: 296
  ident: CR86
  article-title: Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.13060
– volume: 54
  start-page: 3551
  year: 2006
  end-page: 3563
  ident: CR83
  article-title: Impaired skeletal development in interleukin‐6–transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.22175
– volume: 50
  start-page: 975
  year: 2019
  end-page: 991
  ident: CR239
  article-title: The cytokines of asthma
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.018
– volume: 5
  start-page: 48
  year: 2014
  ident: CR120
  article-title: Classical and paradoxical effects of TNF-α on bone homeostasis
  publication-title: Front. Immunol.
– volume: 172
  start-page: 921
  year: 1990
  end-page: 929
  ident: CR147
  article-title: Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.172.3.921
– volume: 76
  start-page: 138
  year: 2015
  end-page: 143
  ident: CR210
  article-title: Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: a case-control study
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2015.08.001
– volume: 70
  start-page: 1143
  year: 1996
  end-page: 1153
  ident: CR217
  article-title: A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
  publication-title: J. Virol.
– volume: 15
  year: 2017
  ident: CR69
  article-title: Proteolytic origin of the soluble human IL-6R and a decisive role of N-glycosylation
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.2000080
– volume: 281
  start-page: 8
  year: 2018
  end-page: 27
  ident: CR34
  article-title: Overview of the IL‐1 family in innate inflammation and acquired immunity
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12621
– volume: 260
  start-page: 2334
  year: 1985
  end-page: 2344
  ident: CR91
  article-title: Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line
  publication-title: J. Biol. Chem.
– volume: 30
  start-page: 1091
  year: 2003
  end-page: 1096
  ident: CR137
  article-title: Increased release of IL‐12p70 by monocytes after periodontal therapy
  publication-title: J. Clin. Periodontol.
  doi: 10.1046/j.0303-6979.2003.00435.x
– volume: 260
  start-page: 2345
  year: 1985
  end-page: 2354
  ident: CR92
  article-title: Human tumor necrosis factor. Production, purification, and characterization
  publication-title: J. Biol. Chem.
– volume: 9
  start-page: 605
  year: 1997
  end-page: 612
  ident: CR211
  article-title: Mitigating effects of interleukin 11 on consecutive courses of 5-fluorouracil-induced ulcerative mucositis in hamsters
  publication-title: Cytokine
  doi: 10.1006/cyto.1997.0208
– volume: 8
  start-page: 201
  year: 2005
  ident: CR117
  article-title: Osteoclasts: culprits in inflammatory osteolysis
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/ar1857
– volume: 39
  start-page: 443
  year: 2013
  end-page: 453
  ident: CR115
  article-title: The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.06.018
– volume: 106
  start-page: 7119
  year: 2009
  end-page: 7124
  ident: CR36
  article-title: IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0902745106
– volume: 114
  start-page: 181
  year: 2003
  end-page: 190
  ident: CR111
  article-title: Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00521-X
– volume: 3
  start-page: 603
  year: 1993
  end-page: 606
  ident: CR132
  article-title: Emerging families of cytokines and receptors
  publication-title: Curr. Biol.
  doi: 10.1016/0960-9822(93)90009-D
– volume: 87
  start-page: 6934
  year: 1990
  end-page: 6938
  ident: CR144
  article-title: Structural design and molecular evolution of a cytokine receptor superfamily
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.87.18.6934
– volume: 93
  start-page: 489
  year: 2013
  end-page: 497
  ident: CR38
  article-title: The role of inflammasome‐derived IL‐1 in driving IL‐17 responses
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1012543
– ident: CR63
– volume: 49
  start-page: 508
  year: 2014
  end-page: 517
  ident: CR124
  article-title: Tumor necrosis factor‐α enhances RANKL expression in gingival epithelial cells via protein kinase A signaling
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12131
– volume: 15
  start-page: 93
  year: 2009
  end-page: 99
  ident: CR215
  article-title: The impact of the IL‐11: IL‐17 ratio on the chronic periodontitis pathogenesis: a preliminary report
  publication-title: Oral. Dis.
  doi: 10.1111/j.1601-0825.2008.01497.x
– volume: 441
  start-page: 235
  year: 2006
  end-page: 238
  ident: CR79
  article-title: Reciprocal developmental pathways for the generation of pathogenic effector T H 17 and regulatory T cells
  publication-title: Nature
  doi: 10.1038/nature04753
– volume: 50
  start-page: 832
  year: 2019
  end-page: 850
  ident: CR143
  article-title: The γc family of cytokines: basic biology to therapeutic ramifications
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.028
– volume: 191
  start-page: 275
  year: 2000
  end-page: 286
  ident: CR116
  article-title: Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL–RANK interaction
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.191.2.275
– volume: 39
  start-page: 294
  year: 2012
  end-page: 303
  ident: CR160
  article-title: promotes Th17 inducing pathways in chronic periodontitis
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2012.03.003
– volume: 20
  start-page: 260
  year: 2016
  end-page: 264
  ident: CR58
  article-title: Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease
  publication-title: J. Indian Soc. Periodontol.
– volume: 6
  start-page: 1123
  year: 2005
  end-page: 1132
  ident: CR156
  article-title: Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1254
– volume: 19
  start-page: 2668
  year: 2005
  end-page: 2681
  ident: CR110
  article-title: TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
  publication-title: Genes Dev.
  doi: 10.1101/gad.1360605
– volume: 10
  start-page: 150
  year: 2017
  end-page: 161
  ident: CR199
  article-title: CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation
  publication-title: Mucosal. Immunol.
  doi: 10.1038/mi.2016.47
– volume: 8
  start-page: 1363
  year: 2007
  end-page: 1371
  ident: CR225
  article-title: Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1537
– volume: 183
  start-page: 2444
  year: 2009
  end-page: 2455
  ident: CR204
  article-title: IL-10 suppresses calcium-mediated costimulation of receptor activator NF-κB signaling during human osteoclast differentiation by inhibiting TREM-2 expression
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0804165
– volume: 15
  start-page: 692
  year: 2015
  end-page: 704
  ident: CR182
  article-title: How leukocytes cross the vascular endothelium
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3908
– volume: 50
  start-page: 924
  year: 2019
  end-page: 940
  ident: CR191
  article-title: Transforming growth factor-β signaling in immunity and cancer
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.024
– volume: 16
  start-page: 779
  year: 2002
  end-page: 790
  ident: CR218
  article-title: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4 T cells
  publication-title: Immunity
  doi: 10.1016/S1074-7613(02)00324-2
– volume: 80
  start-page: 1414
  year: 2009
  end-page: 1420
  ident: CR242
  article-title: Anti‐tumor necrosis factor‐alpha therapy and periodontal parameters in patients with rheumatoid arthritis
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2009.090015
– volume: 22
  start-page: 428
  year: 2013
  end-page: 431
  ident: CR230
  article-title: Comparison of the IL-27 level in gingival crevicular fluid of cross-quadrant and the upper and lower half-mouth subgingival scaling
  publication-title: Shanghai Kou Qiang Yi Xue
– volume: 146
  start-page: 3444
  year: 1991
  end-page: 3451
  ident: CR202
  article-title: IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
  publication-title: J. Immunol.
– volume: 9
  start-page: 1163
  year: 2016
  end-page: 1172
  ident: CR209
  article-title: Characterization of the human immune cell network at the gingival barrier
  publication-title: Mucosal. Immunol.
  doi: 10.1038/mi.2015.136
– volume: 19
  start-page: 997
  year: 2018
  end-page: 1004
  ident: CR229
  article-title: Evaluation of clinical periodontal indices and serum interleukin-27 by one-stage full-mouth disinfection and quadrant scaling and root planing in periodontitis
  publication-title: J. Contemp. Dent. Pr.
  doi: 10.5005/jp-journals-10024-2372
– volume: 71
  start-page: 573
  year: 2000
  end-page: 578
  ident: CR27
  article-title: The effect of interleukin‐11 on the progression of ligature‐induced periodontal disease in the beagle dog
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2000.71.4.573
– volume: 22
  start-page: 120
  year: 2017
  end-page: 128. e124
  ident: CR181
  article-title: Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.06.014
– volume: 40
  start-page: S170
  year: 2013
  end-page: S180
  ident: CR9
  article-title: Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms
  publication-title: J. Periodontol.
  doi: 10.1111/jcpe.12082
– volume: 50
  start-page: 778
  year: 2019
  end-page: 795
  ident: CR32
  article-title: Interleukin-1 and related cytokines in the regulation of inflammation and immunity
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.012
– volume: 10
  start-page: 1178
  year: 2009
  end-page: 1184
  ident: CR203
  article-title: Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1791
– volume: 23
  start-page: 173
  year: 2008
  end-page: 176
  ident: CR53
  article-title: Increased interleukin‐18 in gingival crevicular fluid from periodontitis patients
  publication-title: Oral. Microbiol. Immunol.
  doi: 10.1111/j.1399-302X.2007.00408.x
– volume: 24
  start-page: 128
  year: 2019
  end-page: 135
  ident: CR89
  article-title: Systemic inflammatory burden and local inflammation in periodontitis: what is the link between inflammatory biomarkers in serum and gingival crevicular fluid?
  publication-title: Clin. Exp. Dent. Res
  doi: 10.1002/cre2.162
– volume: 16
  start-page: 5894
  year: 1997
  end-page: 5903
  ident: CR197
  article-title: Identification and functional characterization of a second chain of the interleukin‐10 receptor complex
  publication-title: EMBO J.
  doi: 10.1093/emboj/16.19.5894
– volume: 14
  start-page: 684
  year: 2012
  end-page: 689
  ident: CR60
  article-title: stimulates IL-18 secretion in human monocytic THP-1 cells
  publication-title: Microbes Infect.
  doi: 10.1016/j.micinf.2012.03.002
– volume: 168
  start-page: 5699
  year: 2002
  end-page: 5708
  ident: CR157
  article-title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.168.11.5699
– volume: 35
  start-page: 3
  year: 2014
  end-page: 11
  ident: CR19
  article-title: Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2013.09.001
– volume: 11
  year: 2016
  ident: CR48
  article-title: gingipain-dependently enhances IL-33 production in human gingival epithelial cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0152794
– volume: 30
  start-page: 2174
  year: 1999
  end-page: 2179
  ident: CR154
  article-title: Increased IL-1β, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study
  publication-title: Stroke
  doi: 10.1161/01.STR.30.10.2174
– volume: 16
  start-page: 354
  year: 2015
  end-page: 365
  ident: CR231
  article-title: IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3103
– volume: 8
  start-page: ra88
  year: 2015
  ident: CR75
  article-title: The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaa5157
– volume: 259
  start-page: 686
  year: 1984
  end-page: 691
  ident: CR93
  article-title: Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization
  publication-title: J. Biol. Chem.
– volume: 59
  start-page: 729
  year: 2014
  end-page: 734
  ident: CR39
  article-title: Amount of interleukin-1β and interleukin-1 receptor antagonist in periodontitis and healthy patients
  publication-title: Arch. Oral. Biol.
  doi: 10.1016/j.archoralbio.2014.04.007
– volume: 72
  start-page: 3666
  year: 1975
  end-page: 3670
  ident: CR90
  article-title: An endotoxin-induced serum factor that causes necrosis of tumors
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.72.9.3666
– volume: 177
  start-page: 36
  year: 2006
  end-page: 39
  ident: CR171
  article-title: Cutting edge: interleukin 17 signals through a heteromeric receptor complex
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.177.1.36
– volume: 136
  start-page: 2478
  year: 1986
  end-page: 2482
  ident: CR140
  article-title: Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro
  publication-title: J. Immunol.
– volume: 29
  start-page: 71
  year: 2011
  end-page: 109
  ident: CR196
  article-title: Regulation and functions of the IL-10 family of cytokines in inflammation and disease
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-031210-101312
– volume: 39
  start-page: 276
  year: 2018
  end-page: 287
  ident: CR28
  article-title: Tissue-specific immunity at the oral mucosal barrier
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2017.08.005
– volume: 2019
  start-page: 6034546
  year: 2019
  ident: CR129
  article-title: Periodontitis and rheumatoid arthritis: the same inflammatory mediators?
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2019/6034546
– volume: 13
  start-page: 991
  year: 2012
  end-page: 999
  ident: CR158
  article-title: Induction and molecular signature of pathogenic T 17 cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2416
– volume: 332
  start-page: 65
  year: 2011
  end-page: 68
  ident: CR177
  article-title: Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
  publication-title: Science
  doi: 10.1126/science.1200439
– volume: 51
  start-page: 549
  year: 2016
  end-page: 566
  ident: CR121
  article-title: The effects of tumour necrosis factor‐α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12339
– volume: 19
  start-page: 657
  year: 2003
  end-page: 667
  ident: CR219
  article-title: WSX-1 is required for resistance to infection by regulation of proinflammatory cytokine production
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00298-X
– volume: 86
  start-page: 611
  year: 2015
  end-page: 622
  ident: CR4
  article-title: Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2015.140520
– volume: 25
  start-page: 444
  year: 2019
  end-page: 459
  ident: CR183
  article-title: DEL-1-regulated immune plasticity and inflammatory disorders
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2019.02.010
– volume: 79
  start-page: 1585
  year: 2008
  end-page: 1591
  ident: CR20
  article-title: Cytokines that promote periodontal tissue destruction
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2008.080183
– ident: CR2
– volume: 75
  start-page: 116
  year: 2017
  end-page: 151
  ident: CR3
  article-title: Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12181
– volume: 285
  start-page: 14088
  year: 2010
  end-page: 14100
  ident: CR170
  article-title: Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-α is controlled by IκB-ζ but neither by C/EBP-β nor C/EBP-δ
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.017129
– volume: 264
  start-page: 17595
  year: 1989
  end-page: 17605
  ident: CR97
  article-title: The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding
  publication-title: J. Biol. Chem.
– volume: 38
  start-page: 189
  year: 2017
  end-page: 195
  ident: CR49
  article-title: Increases in IL-33 production by fimbriae and lipopeptide from in mouse bone marrow-derived dendritic cells via toll-like receptor 2
  publication-title: Biomed. Res.
  doi: 10.2220/biomedres.38.189
– volume: 300
  start-page: G568
  year: 2010
  end-page: G576
  ident: CR222
  article-title: Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00329.2010
– volume: 22
  start-page: 304
  year: 2007
  end-page: 312
  ident: CR25
  article-title: The role of cytokines in a ‐induced murine abscess model
  publication-title: Oral. Microbiol. Immunol.
  doi: 10.1111/j.1399-302X.2007.00360.x
– volume: 13
  start-page: 17
  year: 2002
  end-page: 34
  ident: CR151
  article-title: Destructive periodontitis lesions are determined by the nature of the lymphocytic response
  publication-title: Crit. Rev. Oral. Biol. Med.
  doi: 10.1177/154411130201300104
– volume: 8
  start-page: 1390
  year: 2007
  end-page: 1397
  ident: CR159
  article-title: TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T -17 cell–mediated pathology
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1539
– volume: 32
  start-page: 51
  year: 2014
  end-page: 82
  ident: CR192
  article-title: TGF-β activation and function in immunity
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120257
– volume: 15
  start-page: 985
  year: 2001
  end-page: 995
  ident: CR164
  article-title: IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00243-6
– volume: 46
  start-page: 592
  year: 2011
  end-page: 598
  ident: CR54
  article-title: Interleukin‐17 and interleukin‐18 levels in saliva and plasma of patients with chronic periodontitis
  publication-title: J. Periodontal Res.
– volume: 30
  start-page: 1046
  year: 2003
  end-page: 1052
  ident: CR123
  article-title: Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis
  publication-title: J. Clin. Periodontol.
  doi: 10.1046/j.0303-6979.2003.00425.x
– volume: 69
  start-page: 142
  year: 2015
  end-page: 159
  ident: CR178
  article-title: Basic biology and role of interleukin‐17 in immunity and inflammation
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12083
– volume: 41
  start-page: 853
  year: 2014
  end-page: 861
  ident: CR82
  article-title: Cytokine gene expression profiles during initiation, progression and resolution of periodontitis
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12286
– volume: 60
  start-page: 171
  year: 2012
  end-page: 178
  ident: CR161
  article-title: Up-regulation of IL-23 p19 expression in human periodontal ligament fibroblasts by IL-1β via concurrent activation of the NF-κB and MAPKs/AP-1 pathways
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2012.05.016
– volume: 45
  start-page: 150
  year: 2018
  end-page: 166
  ident: CR128
  article-title: An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12803
– volume: 14
  start-page: 585
  year: 2014
  end-page: 600
  ident: CR173
  article-title: The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3707
– volume: 79
  start-page: 1645
  year: 2008
  end-page: 1651
  ident: CR241
  article-title: Anti–TNF‐α immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2008.070616
– volume: 6
  start-page: 31
  year: 2014
  ident: CR240
  article-title: Advances in the treatment of rheumatoid arthritis
  publication-title: F1000 Prime Rep.
  doi: 10.12703/P6-31
– volume: 50
  start-page: 992
  year: 2019
  end-page: 1006
  ident: CR236
  article-title: Cytokine networks in the pathophysiology of inflammatory bowel disease
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.017
– volume: 94
  start-page: 968
  year: 2015
  end-page: 975
  ident: CR51
  article-title: IL-33 exacerbates periodontal disease through induction of RANKL
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034515577815
– volume: 13
  start-page: 595
  year: 2013
  end-page: 601
  ident: CR17
  article-title: Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2013.04.005
– volume: 20
  start-page: 606
  year: 2016
  end-page: 617
  ident: CR176
  article-title: IL-17 receptor signaling in oral epithelial cells is critical for protection against oropharyngeal candidiasis
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.10.001
– volume: 10
  start-page: eaat0797
  year: 2018
  ident: CR180
  article-title: A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aat0797
– volume: 174
  start-page: 1209
  year: 1991
  end-page: 1220
  ident: CR198
  article-title: Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.174.5.1209
– volume: 76
  start-page: 785
  year: 2005
  end-page: 790
  ident: CR139
  article-title: Interleukin‐18 concentrations and the pathogenesis of periodontal disease
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2005.76.5.785
– volume: 19
  start-page: 703
  year: 2019
  end-page: 710
  ident: CR61
  article-title: IL18 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NFκB signaling
  publication-title: Mol. Med. Rep.
– volume: 60
  start-page: 77
  year: 2015
  end-page: 83
  ident: CR46
  article-title: Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease
  publication-title: Arch. Oral. Biol.
  doi: 10.1016/j.archoralbio.2014.08.021
– volume: 23
  start-page: 1983
  year: 2017
  end-page: 1995
  ident: CR220
  article-title: Interleukin-27 is a potential rescue therapy for acute severe colitis through interleukin-10–dependent, T-cell–independent attenuation of colonic mucosal innate immune responses
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1097/MIB.0000000000001274
– volume: 239
  start-page: 55
  year: 1988
  end-page: 57
  ident: CR11
  article-title: Implantation of in nonhuman primates initiates progression of periodontitis
  publication-title: Science
  doi: 10.1126/science.3336774
– volume: 4
  start-page: 387
  year: 1996
  end-page: 396
  ident: CR101
  article-title: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80252-6
– volume: 64
  start-page: 57
  year: 2014
  end-page: 80
  ident: CR149
  article-title: Inflammatory and immune pathways in the pathogenesis of periodontal disease
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12002
– volume: 19
  start-page: 70
  year: 1992
  end-page: 72
  ident: CR10
  article-title: The specific plaque hypothesis and the antimicrobial treatment of periodontal disease
  publication-title: Dent. Update
– volume: 20
  start-page: 40
  year: 2019
  end-page: 49
  ident: CR184
  article-title: DEL-1 promotes macrophage efferocytosis and clearance of inflammation
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0249-1
– volume: 13
  start-page: 359
  year: 2017
  end-page: 367
  ident: CR237
  article-title: Pathogenesis of ankylosing spondylitis—recent advances and future directions
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2017.56
– volume: 412
  start-page: 346
  year: 2001
  end-page: 351
  ident: CR108
  article-title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK
  publication-title: Nature
  doi: 10.1038/35085597
– volume: 3
  start-page: 133
  year: 2003
  end-page: 146
  ident: CR134
  article-title: Interleukin-12 and the regulation of innate resistance and adaptive immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri1001
– volume: 6
  start-page: 256ra134
  year: 2014
  ident: CR165
  article-title: Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3009124
– volume: 13
  start-page: 465
  year: 2012
  end-page: 473
  ident: CR26
  article-title: The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2260
– volume: 41
  start-page: 748
  year: 2014
  end-page: 759
  ident: CR22
  article-title: TNF‐α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12279
– volume: 7
  start-page: 479
  year: 2016
  ident: CR64
  article-title: Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2016.00479
– volume: 22
  start-page: 245
  year: 2006
  end-page: 257
  ident: CR102
  article-title: Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.03.026
– volume: 1
  start-page: 1
  year: 2019
  end-page: 12
  ident: CR87
  article-title: Production of interferon gamma, interleukin 6 and interleukin 1β by human peripheral blood mononuclear cells stimulated with novel Lys‐gingipain synthetic peptides
  publication-title: J. Periodontol.
– volume: 104
  start-page: 1527
  year: 1999
  end-page: 1537
  ident: CR212
  article-title: Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI6910
– volume: 147
  start-page: 577
  year: 2011
  end-page: 589
  ident: CR193
  article-title: Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
  publication-title: Cell
  doi: 10.1016/j.cell.2011.09.044
– volume: 8
  start-page: 323
  year: 2014
  end-page: 327
  ident: CR40
  article-title: Clinical improvement following therapy for periodontitis: association with a decrease in IL1 and IL6
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2014.1724
– volume: 258
  start-page: 593
  year: 1992
  end-page: 597
  ident: CR70
  article-title: Interleukin-6 and its receptor: a paradigm for cytokines
  publication-title: Science
  doi: 10.1126/science.1411569
– volume: 13
  start-page: 418
  year: 2016
  end-page: 431
  ident: CR172
  article-title: The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity
  publication-title: Cell. Mol. Immunol.
  doi: 10.1038/cmi.2015.105
– volume: 193
  start-page: 1007
  year: 1976
  end-page: 1008
  ident: CR186
  article-title: Selective in vitro growth of T lymphocytes from normal human bone marrows
  publication-title: Science
  doi: 10.1126/science.181845
– volume: 84
  start-page: 311
  year: 2008
  end-page: 318
  ident: CR205
  article-title: Characterization of CD4+ CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0108014
– volume: 184
  start-page: 2130
  year: 2010
  end-page: 2139
  ident: CR76
  article-title: Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901528
– volume: 23
  start-page: 854
  year: 2017
  end-page: 865
  ident: CR175
  article-title: IL‐17: overview and role in oral immunity and microbiome
  publication-title: Oral. Dis.
  doi: 10.1111/odi.12598
– volume: 2012
  start-page: 174764
  year: 2012
  ident: CR213
  article-title: IL-17 and IL-11 G. C. F. levels in aggressive and chronic periodontitis patients: relation to PCR bacterial detection
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2012/174764
– volume: 7
  start-page: 307ra155
  year: 2015
  ident: CR185
  article-title: DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aac5380
– volume: 51
  start-page: 261
  year: 2009
  end-page: 266
  ident: CR57
  article-title: Exploring the role of Th1 cytokines: interleukin-17 and interleukin-18 in periodontal health and disease
  publication-title: J. Oral. Sci.
  doi: 10.2334/josnusd.51.261
– volume: 87
  start-page: 990
  year: 2016
  end-page: 996
  ident: CR126
  article-title: Tumor necrosis factor‐α and interleukin (IL)‐1β, IL‐6, and IL‐8 impair migration and induce apoptosis of gingival fibroblasts and epithelial cells, delaying wound healing
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2016.150713
– volume: 8
  start-page: 247
  year: 2007
  end-page: 256
  ident: CR169
  article-title: The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1439
– volume: 166
  start-page: 4915
  year: 2001
  end-page: 4921
  ident: CR141
  article-title: IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.166.8.4915
– volume: 43
  start-page: 727
  year: 2016
  end-page: 745
  ident: CR81
  article-title: Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis: a meta‐analysis
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12557
– volume: 5
  start-page: 511
  year: 2014
  ident: CR119
  article-title: Biology of the RANKL–RANK–OPG system in immunity, bone, and beyond
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00511
– volume: 34
  start-page: 566
  year: 2011
  end-page: 578
  ident: CR200
  article-title: Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.03.018
– volume: 60
  start-page: 1463
  year: 2015
  end-page: 1470
  ident: CR21
  article-title: Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population
  publication-title: Arch. Oral. Biol.
  doi: 10.1016/j.archoralbio.2015.06.018
– volume: 13
  start-page: 715
  year: 2000
  end-page: 725
  ident: CR131
  article-title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)00070-4
– volume: 169
  start-page: 987
  year: 2006
  end-page: 998
  ident: CR125
  article-title: B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2006.060180
– volume: 84
  start-page: 136
  year: 2013
  end-page: 142
  ident: CR243
  article-title: Periodontal condition of patients with autoimmune diseases and the effect of anti‐tumor necrosis factor‐α therapy
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2012.120009
– volume: 25
  start-page: 596
  year: 2019
  end-page: 608
  ident: CR41
  article-title: Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2 diabetes
  publication-title: Oral. Dis.
– volume: 10
  start-page: 857
  year: 2009
  end-page: 863
  ident: CR78
  article-title: Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1767
– volume: 18
  start-page: 315
  year: 2018
  end-page: 331
  ident: CR122
  article-title: Tumor necrosis factor-alpha in gingival crevicular fluid as a diagnostic marker for periodontal diseases: a systematic review
  publication-title: J. Evid. Based Dent. Pract.
  doi: 10.1016/j.jebdp.2018.04.001
– volume: 201
  start-page: 233
  year: 2005
  end-page: 240
  ident: CR37
  article-title: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20041257
– volume: 83
  start-page: 1425
  year: 2012
  end-page: 1431
  ident: CR214
  article-title: The gingival crevicular fluid levels of interleukin‐11 and interleukin‐17 in patients with aggressive periodontitis
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2012.110585
– volume: 6
  start-page: 727
  year: 2010
  end-page: 730
  ident: CR8
  article-title: Periodontitis in RA—the citrullinated enolase connection
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2010.139
– volume: 84
  start-page: 683
  year: 2013
  end-page: 693
  ident: CR127
  article-title: Tumor necrosis factor‐α inhibits transforming growth factor‐β–stimulated myofibroblastic differentiation and extracellular matrix production in human gingival fibroblasts
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2012.120225
– volume: 180
  start-page: 2752
  year: 2008
  end-page: 2756
  ident: CR227
  article-title: Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.5.2752
– volume: 19
  start-page: 641
  year: 2003
  end-page: 644
  ident: CR136
  article-title: The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00296-6
– volume: 133
  start-page: 693
  year: 2008
  end-page: 703
  ident: CR112
  article-title: TNF-α induces two distinct caspase-8 activation pathways
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.036
– volume: 103
  start-page: 1345
  year: 1999
  end-page: 1352
  ident: CR155
  article-title: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI5703
– volume: 50
  start-page: 892
  year: 2019
  end-page: 906
  ident: CR163
  article-title: The IL-17 family of cytokines in health and disease
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.021
– volume: 89
  start-page: 879
  year: 2010
  end-page: 902
  ident: CR6
  article-title: “Gum bug, leave my heart alone!”—epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034510375281
– volume: 86
  start-page: 301
  year: 2015
  end-page: 309
  ident: CR228
  article-title: Increased expression of interleukin (IL)‐35 and IL‐17, but not IL‐27, in gingival tissues with chronic periodontitis
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2014.140293
– volume: 12
  start-page: 63
  year: 2016
  end-page: 68
  ident: CR235
  article-title: Cytokines in rheumatoid arthritis—shaping the immunological landscape
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2015.171
– volume: 63
  start-page: 45
  year: 2014
  end-page: 52
  ident: CR23
  article-title: Interleukin-18 promoter polymorphisms and plasma levels are associated with increased risk of periodontitis: a meta-analysis
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-013-0669-1
– volume: 11
  year: 2016
  ident: CR43
  article-title: Interleukin-33 and RANK-L interplay in the alveolar bone loss associated to periodontitis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0168080
– volume: 232
  start-page: 215
  year: 2014
  end-page: 222
  ident: CR62
  article-title: Increased interleukin-18 in the gingival tissues evokes chronic periodontitis after bacterial infection
  publication-title: Tohoku J. Exp. Med.
  doi: 10.1620/tjem.232.215
– volume: 23
  start-page: 428
  year: 2012
  end-page: 432
  ident: CR56
  article-title: Effectiveness of non-surgical treatment to reduce IL-18 levels in the gingival crevicular fluid of patients with periodontal disease
  publication-title: Braz. Dent. J.
  doi: 10.1590/S0103-64402012000400020
– volume: 281
  start-page: 6642
  year: 2006
  end-page: 6647
  ident: CR145
  article-title: The structure of the interleukin-15α receptor and its implications for ligand binding
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M513118200
– volume: 83
  start-page: 362
  year: 2012
  end-page: 368
  ident: CR45
  article-title: Interleukin‐33 levels in gingival crevicular fluid, saliva, or plasma do not differentiate chronic periodontitis
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2011.110239
– volume: 91
  start-page: 574
  year: 2012
  end-page: 579
  ident: CR179
  article-title: The presence of IL-17+/FOXP3+ double-positive cells in periodontitis
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034512446341
– volume: 281
  start-page: 13636
  year: 2006
  end-page: 13643
  ident: CR103
  article-title: Ubiquitination of RIP is required for tumor necrosis factor α-induced NF-κB activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M600620200
– volume: 150
  start-page: 286
  year: 2007
  end-page: 297
  ident: CR246
  article-title: Effects of etanercept, a tumour necrosis factor‐α antagonist, in an experimental model of periodontitis in rats
  publication-title: Br. J. Pharm.
  doi: 10.1038/sj.bjp.0706979
– volume: 15
  start-page: 30
  year: 2015
  end-page: 44
  ident: CR1
  article-title: Periodontitis: from microbial immune subversion to systemic inflammation
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3785
– volume: 7
  start-page: 1016
  year: 2013
  end-page: 1025
  ident: CR18
  article-title: The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
  publication-title: ISME J.
  doi: 10.1038/ismej.2012.174
– volume: 10
  start-page: 497
  year: 2011
  end-page: 506
  ident: CR16
  article-title: Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2011.10.006
– volume: 98
  start-page: 148
  year: 2019
  end-page: 156
  ident: CR29
  article-title: The oral microbiota is modified by systemic diseases
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034518805739
– volume: 147
  start-page: 3815
  year: 1991
  end-page: 3822
  ident: CR201
  article-title: IL-10 inhibits cytokine production by activated macrophages
  publication-title: J. Immunol.
– volume: 7
  start-page: 738
  year: 2011
  end-page: 748
  ident: CR7
  article-title: Diabetes mellitus and periodontitis: a tale of two common interrelated diseases
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2011.106
– volume: 45
  start-page: 99
  year: 2009
  end-page: 104
  ident: CR59
  article-title: culture supernatants differentially regulate Interleukin-1β and Interleukin-18 in human monocytic cells
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2008.11.005
– volume: 2013
  start-page: 181849
  year: 2013
  ident: CR118
  article-title: Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo
  publication-title: Clin. Dev. Immunol.
  doi: 10.1155/2013/181849
– volume: 88
  start-page: 1329
  year: 2017
  end-page: 1338
  ident: CR42
  article-title: Salivary levels of NLRP3 inflammasome‐related proteins as potential biomarkers of periodontal clinical status
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2017.170244
– volume: 13
  start-page: 290
  year: 2012
  end-page: 299
  ident: CR67
  article-title: The composition and signaling of the IL-35 receptor are unconventional
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2227
– volume: 12
  start-page: 560
  year: 2011
  end-page: 567
  ident: CR223
  article-title: RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2027
– volume: 36
  start-page: 396
  year: 2009
  end-page: 403
  ident: CR206
  article-title: Over‐expression of forkhead box P3 and its association with receptor activator of nuclear factor‐κ B ligand, interleukin (IL)‐17, IL‐10 and transforming growth factor‐β during the progression of chronic periodontitis
  publication-title: J. Clin. Periodo.
  doi: 10.1111/j.1600-051X.2009.01390.x
– volume: 17
  start-page: 522
  year: 2011
  end-page: 529
  ident: CR55
  article-title: IL‐12 and IL‐18 levels in serum and gingival tissue in aggressive and chronic periodontitis
  publication-title: Oral. Dis.
  doi: 10.1111/j.1601-0825.2011.01798.x
– volume: 148
  start-page: 213
  year: 2012
  end-page: 227
  ident: CR114
  article-title: Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.031
– volume: 18
  start-page: 4109
  year: 1998
  end-page: 4117
  ident: CR73
  article-title: Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.18.7.4109
– volume: 8
  start-page: 1372
  year: 2007
  end-page: 1379
  ident: CR226
  article-title: Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1540
– volume: 70
  start-page: 11
  year: 2014
  end-page: 20
  ident: CR74
  article-title: Interleukin-6 and its receptors: a highly regulated and dynamic system
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2014.05.024
– volume: 147
  start-page: 565
  year: 2011
  end-page: 576
  ident: CR194
  article-title: Master transcription factors determine cell-type-specific responses to TGF-b signaling
  publication-title: Cell
  doi: 10.1016/j.cell.2011.08.050
– volume: 84
  start-page: 639
  year: 2005
  end-page: 643
  ident: CR208
  article-title: Regulatory T-cells infiltrate periodontal disease tissues
  publication-title: J. Dent. Res.
  doi: 10.1177/154405910508400711
– volume: 98
  start-page: 813
  year: 2019
  end-page: 821
  ident: CR233
  article-title: IL-37-and IL-35/IL-37-producing plasma cells in chronic periodontitis
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034519847443
– volume: 2
  start-page: a000158
  year: 2010
  ident: CR106
  article-title: The IKK complex, a central regulator of NF-κB activation
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a000158
– volume: 55
  start-page: 9
  year: 2018
  end-page: 14
  ident: CR65
  article-title: IL-6: a cytokine at the crossroads of autoimmunity
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2018.09.002
– volume: 15
  start-page: 535
  year: 2004
  end-page: 548
  ident: CR109
  article-title: TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2004.08.008
– volume: 50
  start-page: 812
  year: 2019
  end-page: 831
  ident: CR66
  article-title: Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.027
– volume: 8
  start-page: 448
  year: 2007
  end-page: 450
  ident: CR135
  article-title: Trawling for treasure: tales of T-bet
  publication-title: Nat. Immunol.
  doi: 10.1038/ni0507-448
– volume: 53
  start-page: 45
  year: 1988
  end-page: 53
  ident: CR95
  article-title: A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF
  publication-title: Cell
  doi: 10.1016/0092-8674(88)90486-2
– volume: 35
  start-page: 365
  year: 2008
  end-page: 370
  ident: CR216
  article-title: Interleukin‐11, interleukin‐1β, interleukin‐12 and the pathogenesis of inflammatory periodontal diseases
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/j.1600-051X.2008.01212.x
– volume: 32
  start-page: 227
  year: 2014
  end-page: 255
  ident: CR238
  article-title: Immunology of psoriasis
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120225
– volume: 89
  start-page: 1349
  year: 2010
  end-page: 1363
  ident: CR150
  article-title: Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034510376402
– volume: 385
  start-page: 729
  year: 1997
  end-page: 733
  ident: CR96
  article-title: A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
  publication-title: Nature
  doi: 10.1038/385729a0
– volume: 36
  start-page: 831
  year: 2009
  end-page: 844
  ident: CR105
  article-title: Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.10.013
– volume: 27
  start-page: 519
  year: 2009
  end-page: 550
  ident: CR33
  article-title: Immunological and inflammatory functions of the interleukin-1 family
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.021908.132612
– volume: 378
  start-page: 88
  year: 1995
  end-page: 91
  ident: CR52
  article-title: Cloning of a new cytokine that induces IFN-γ production by T cells
  publication-title: Nature
  doi: 10.1038/378088a0
– volume: 142
  start-page: 460
  year: 2018
  end-page: 469. e467
  ident: CR166
  article-title: Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2018.03.019
– volume: 162
  start-page: 1726
  year: 1985
  end-page: 1731
  ident: CR148
  article-title: Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.162.5.1726
– volume: 210
  start-page: 171
  year: 2006
  end-page: 186
  ident: CR107
  article-title: Circuitry of nuclear factor κB signaling
  publication-title: Immunol. Rev.
  doi: 10.1111/j.0105-2896.2006.00375.x
– volume: 2016
  start-page: 9612421
  year: 2016
  ident: CR80
  article-title: Interleukin-6-174G/C polymorphism contributes to periodontitis susceptibility: an updated meta-analysis of 21 case-control studies
  publication-title: Dis. Markers
– volume: 2
  start-page: ra63
  year: 2009
  ident: CR168
  article-title: Act1, a U-box E3 ubiquitin ligase for IL-17 signaling
  publication-title: Sci. Signal.
– volume: 87
  start-page: 817
  year: 2008
  end-page: 828
  ident: CR31
  article-title: A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17
  publication-title: J. Dent. Res.
  doi: 10.1177/154405910808700908
– volume: 257
  start-page: 379
  year: 1992
  end-page: 382
  ident: CR187
  article-title: Cloning of the gamma chain of the human IL-2 receptor
  publication-title: Science
  doi: 10.1126/science.1631559
– volume: 374
  start-page: 1
  year: 2003
  end-page: 20
  ident: CR71
  article-title: Principles of interleukin (IL)-6-type cytokine signalling and its regulation
  publication-title: Biochem. J.
  doi: 10.1042/bj20030407
– volume: 15
  start-page: 362
  year: 2015
  end-page: 374
  ident: CR94
  article-title: Regulation of tumour necrosis factor signalling: live or let die
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3834
– volume: 25
  start-page: 134
  year: 1998
  end-page: 144
  ident: CR12
  article-title: Microbial complexes in subgingival plaque
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/j.1600-051X.1998.tb02419.x
– volume: 29
  start-page: 137
  year: 2002
  end-page: 143
  ident: CR245
  article-title: Clinical, radiographic and biochemical assessment of IL‐1/TNF‐α antagonist inhibition of bone loss in experimental periodontitis
  publication-title: J. Clin. Periodontol.
  doi: 10.1034/j.1600-051x.2002.290208.x
– volume: 172
  start-page: 5149
  year: 2004
  end-page: 5153
  ident: CR195
  article-title: Cutting edge: TGF-β induces a regulatory phenotype in CD4+ CD25− T cells through Foxp3 induction and down-regulation of Smad7
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.172.9.5149
– volume: 12
  start-page: 9785
  year: 2018
  end-page: 9799
  ident: CR247
  article-title: Nanofibrous spongy microspheres to distinctly release miRNA and growth factors to enrich regulatory T cells and rescue periodontal bone loss
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b08976
– volume: 26
  start-page: 229
  year: 2011
  end-page: 240
  ident: CR14
  article-title: Synergistic virulence of and in a murine periodontitis model
  publication-title: Mol. Oral. Microbiol
  doi: 10.1111/j.2041-1014.2011.00612.x
– volume: 3
  start-page: 811
  year: 1995
  end-page: 821
  ident: CR152
  article-title: encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
  publication-title: Immunity
  doi: 10.1016/1074-7613(95)90070-5
– volume: 46
  start-page: 438
  year: 2019
  end-page: 447
  ident: CR85
  article-title: Traumatic occlusion aggravates bone loss during periodontitis and activates Hippo‐YAP pathway
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.13065
– volume: 50
  start-page: 1007
  year: 2019
  end-page: 1023
  ident: CR68
  article-title: Targeting interleukin-6 signaling in clinic
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.026
– volume: 9
  start-page: 482
  year: 2010
  end-page: 493
  ident: CR99
  article-title: TNF receptor 2 pathway: drug target for autoimmune diseases
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3030
– volume: 19
  start-page: 175
  year: 2015
  end-page: 181
  ident: CR35
  article-title: Polymorphic regions in the interleukin-1 gene and susceptibility to chronic periodontitis: a genetic association study
  publication-title: Genet. Test. Mol. Biomark.
  doi: 10.1089/gtmb.2014.0275
– volume: 49
  start-page: 55
  year: 2014
  end-page: 61
  ident: CR47
  article-title: Gingival crevicular fluid levels of interferon‐γ, but not interleukin‐4 or‐33 or thymic stromal lymphopoietin, are increased in inflamed sites in patients with periodontal disease
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12078
– volume: 308
  start-page: 1477
  year: 2005
  end-page: 1480
  ident: CR146
  article-title: The structure of interleukin-2 complexed with its alpha receptor
  publication-title: Science
  doi: 10.1126/science.1109745
– volume: 41
  start-page: 1360
  year: 2017
  end-page: 1369
  ident: CR84
  article-title: IL-6 enhances osteocyte-mediated osteoclastogenesis by promoting JAK2 and RANKL activity
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000465455
– volume: 387
  start-page: 924
  year: 1997
  end-page: 929
  ident: CR72
  article-title: Structure and function of a new STAT-induced STAT inhibitor
  publication-title: Nature
  doi: 10.1038/43219
– volume: 189
  start-page: 2079
  year: 2012
  end-page: 2083
  ident: CR224
  article-title: Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1200131
– volume: 80
  start-page: 535
  year: 2009
  end-page: 540
  ident: CR244
  article-title: Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2009.080447
– volume: 147
  start-page: 565
  year: 2011
  ident: 64_CR194
  publication-title: Cell
  doi: 10.1016/j.cell.2011.08.050
– volume: 147
  start-page: 577
  year: 2011
  ident: 64_CR193
  publication-title: Cell
  doi: 10.1016/j.cell.2011.09.044
– volume: 22
  start-page: 304
  year: 2007
  ident: 64_CR25
  publication-title: Oral. Microbiol. Immunol.
  doi: 10.1111/j.1399-302X.2007.00360.x
– volume: 3
  start-page: 133
  year: 2003
  ident: 64_CR134
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri1001
– volume: 146
  start-page: 3444
  year: 1991
  ident: 64_CR202
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.146.10.3444
– volume: 54
  start-page: 3551
  year: 2006
  ident: 64_CR83
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.22175
– volume: 60
  start-page: 1463
  year: 2015
  ident: 64_CR21
  publication-title: Arch. Oral. Biol.
  doi: 10.1016/j.archoralbio.2015.06.018
– volume: 11
  year: 2016
  ident: 64_CR43
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0168080
– volume: 15
  start-page: 535
  year: 2004
  ident: 64_CR109
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2004.08.008
– ident: 64_CR63
– volume: 8
  start-page: 448
  year: 2007
  ident: 64_CR135
  publication-title: Nat. Immunol.
  doi: 10.1038/ni0507-448
– volume: 30
  start-page: 1046
  year: 2003
  ident: 64_CR123
  publication-title: J. Clin. Periodontol.
  doi: 10.1046/j.0303-6979.2003.00425.x
– volume: 49
  start-page: 237
  year: 2014
  ident: 64_CR162
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12100
– volume: 136
  start-page: 2478
  year: 1986
  ident: 64_CR140
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.136.7.2478
– volume: 46
  start-page: 438
  year: 2019
  ident: 64_CR85
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.13065
– volume: 8
  start-page: 1390
  year: 2007
  ident: 64_CR159
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1539
– volume: 193
  start-page: 1007
  year: 1976
  ident: 64_CR186
  publication-title: Science
  doi: 10.1126/science.181845
– volume: 91
  start-page: 574
  year: 2012
  ident: 64_CR179
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034512446341
– volume: 41
  start-page: 1360
  year: 2017
  ident: 64_CR84
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000465455
– volume: 38
  start-page: 13
  year: 2013
  ident: 64_CR189
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.01.004
– volume: 5
  start-page: 48
  year: 2014
  ident: 64_CR120
  publication-title: Front. Immunol.
– volume: 281
  start-page: 8
  year: 2018
  ident: 64_CR34
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12621
– volume: 13
  start-page: 715
  year: 2000
  ident: 64_CR131
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)00070-4
– volume: 50
  start-page: 1007
  year: 2019
  ident: 64_CR68
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.026
– volume: 53
  start-page: 45
  year: 1988
  ident: 64_CR95
  publication-title: Cell
  doi: 10.1016/0092-8674(88)90486-2
– volume: 3
  start-page: 811
  year: 1995
  ident: 64_CR152
  publication-title: Immunity
  doi: 10.1016/1074-7613(95)90070-5
– volume: 45
  start-page: 99
  year: 2009
  ident: 64_CR59
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2008.11.005
– volume: 84
  start-page: 311
  year: 2008
  ident: 64_CR205
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0108014
– volume: 55
  start-page: 9
  year: 2018
  ident: 64_CR65
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2018.09.002
– volume: 83
  start-page: 1425
  year: 2012
  ident: 64_CR214
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2012.110585
– volume: 89
  start-page: 1349
  year: 2010
  ident: 64_CR150
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034510376402
– volume: 257
  start-page: 379
  year: 1992
  ident: 64_CR187
  publication-title: Science
  doi: 10.1126/science.1631559
– volume: 9
  start-page: 605
  year: 1997
  ident: 64_CR211
  publication-title: Cytokine
  doi: 10.1006/cyto.1997.0208
– volume: 22
  start-page: 428
  year: 2013
  ident: 64_CR230
  publication-title: Shanghai Kou Qiang Yi Xue
– volume: 15
  start-page: 30
  year: 2015
  ident: 64_CR1
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3785
– volume: 86
  start-page: 301
  year: 2015
  ident: 64_CR228
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2014.140293
– volume: 59
  start-page: 729
  year: 2014
  ident: 64_CR39
  publication-title: Arch. Oral. Biol.
  doi: 10.1016/j.archoralbio.2014.04.007
– volume: 36
  start-page: 396
  year: 2009
  ident: 64_CR206
  publication-title: J. Clin. Periodo.
  doi: 10.1111/j.1600-051X.2009.01390.x
– volume: 81
  start-page: 495
  year: 1995
  ident: 64_CR100
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90070-5
– volume: 45
  start-page: 150
  year: 2018
  ident: 64_CR128
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12803
– volume: 232
  start-page: 215
  year: 2014
  ident: 64_CR62
  publication-title: Tohoku J. Exp. Med.
  doi: 10.1620/tjem.232.215
– volume: 60
  start-page: 171
  year: 2012
  ident: 64_CR161
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2012.05.016
– volume: 172
  start-page: 921
  year: 1990
  ident: 64_CR147
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.172.3.921
– volume: 50
  start-page: 832
  year: 2019
  ident: 64_CR143
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.028
– volume: 46
  start-page: 286
  year: 2019
  ident: 64_CR86
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.13060
– volume: 22
  start-page: 245
  year: 2006
  ident: 64_CR102
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.03.026
– volume: 13
  start-page: 418
  year: 2016
  ident: 64_CR172
  publication-title: Cell. Mol. Immunol.
  doi: 10.1038/cmi.2015.105
– volume: 79
  start-page: 1645
  year: 2008
  ident: 64_CR241
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2008.070616
– volume: 13
  start-page: 17
  year: 2002
  ident: 64_CR151
  publication-title: Crit. Rev. Oral. Biol. Med.
  doi: 10.1177/154411130201300104
– volume: 39
  start-page: 276
  year: 2018
  ident: 64_CR28
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2017.08.005
– volume: 6
  start-page: 256ra134
  year: 2014
  ident: 64_CR165
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3009124
– volume: 71
  start-page: 573
  year: 2000
  ident: 64_CR27
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2000.71.4.573
– volume: 50
  start-page: 778
  year: 2019
  ident: 64_CR32
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.012
– volume: 30
  start-page: 2174
  year: 1999
  ident: 64_CR154
  publication-title: Stroke
  doi: 10.1161/01.STR.30.10.2174
– volume: 90
  start-page: 653
  year: 2011
  ident: 64_CR207
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034510397838
– volume: 79
  start-page: 1585
  year: 2008
  ident: 64_CR20
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2008.080183
– volume: 93
  start-page: 489
  year: 2013
  ident: 64_CR38
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1012543
– volume: 179
  start-page: 2359
  year: 2007
  ident: 64_CR113
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.4.2359
– volume: 17
  start-page: 522
  year: 2011
  ident: 64_CR55
  publication-title: Oral. Dis.
  doi: 10.1111/j.1601-0825.2011.01798.x
– volume: 19
  start-page: 70
  year: 1992
  ident: 64_CR10
  publication-title: Dent. Update
– volume: 25
  start-page: 596
  year: 2019
  ident: 64_CR41
  publication-title: Oral. Dis.
  doi: 10.1111/odi.13003
– volume: 8
  start-page: 481
  year: 2010
  ident: 64_CR13
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2337
– volume: 87
  start-page: 817
  year: 2008
  ident: 64_CR31
  publication-title: J. Dent. Res.
  doi: 10.1177/154405910808700908
– volume: 332
  start-page: 65
  year: 2011
  ident: 64_CR177
  publication-title: Science
  doi: 10.1126/science.1200439
– volume: 19
  start-page: 703
  year: 2019
  ident: 64_CR61
  publication-title: Mol. Med. Rep.
– volume: 23
  start-page: 854
  year: 2017
  ident: 64_CR175
  publication-title: Oral. Dis.
  doi: 10.1111/odi.12598
– volume: 87
  start-page: 6934
  year: 1990
  ident: 64_CR144
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.87.18.6934
– volume: 174
  start-page: 1209
  year: 1991
  ident: 64_CR198
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.174.5.1209
– volume: 29
  start-page: 137
  year: 2002
  ident: 64_CR245
  publication-title: J. Clin. Periodontol.
  doi: 10.1034/j.1600-051x.2002.290208.x
– volume: 38
  start-page: 189
  year: 2017
  ident: 64_CR49
  publication-title: Biomed. Res.
  doi: 10.2220/biomedres.38.189
– volume: 13
  start-page: 290
  year: 2012
  ident: 64_CR67
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2227
– volume: 67
  start-page: 1474
  year: 2008
  ident: 64_CR221
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/ard.2007.083360
– volume: 19
  start-page: 175
  year: 2015
  ident: 64_CR35
  publication-title: Genet. Test. Mol. Biomark.
  doi: 10.1089/gtmb.2014.0275
– volume: 64
  start-page: 57
  year: 2014
  ident: 64_CR149
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12002
– volume: 260
  start-page: 2345
  year: 1985
  ident: 64_CR92
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)89560-6
– volume: 162
  start-page: 1726
  year: 1985
  ident: 64_CR148
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.162.5.1726
– volume: 25
  start-page: 444
  year: 2019
  ident: 64_CR183
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2019.02.010
– volume: 8
  start-page: ZC90
  year: 2014
  ident: 64_CR138
  publication-title: J. Clin. Diagn. Res.
– volume: 12
  start-page: 560
  year: 2011
  ident: 64_CR223
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2027
– volume: 16
  start-page: 5894
  year: 1997
  ident: 64_CR197
  publication-title: EMBO J.
  doi: 10.1093/emboj/16.19.5894
– volume: 18
  start-page: 4109
  year: 1998
  ident: 64_CR73
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.18.7.4109
– volume: 13
  start-page: 359
  year: 2017
  ident: 64_CR237
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2017.56
– volume: 98
  start-page: 148
  year: 2019
  ident: 64_CR29
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034518805739
– volume: 10
  start-page: eaat0797
  year: 2018
  ident: 64_CR180
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aat0797
– volume: 15
  start-page: 985
  year: 2001
  ident: 64_CR164
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00243-6
– volume: 94
  start-page: 968
  year: 2015
  ident: 64_CR51
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034515577815
– volume: 11
  year: 2016
  ident: 64_CR48
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0152794
– volume: 88
  start-page: 1329
  year: 2017
  ident: 64_CR42
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2017.170244
– volume: 4
  start-page: 387
  year: 1996
  ident: 64_CR101
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80252-6
– volume: 76
  start-page: 138
  year: 2015
  ident: 64_CR210
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2015.08.001
– volume: 168
  start-page: 5699
  year: 2002
  ident: 64_CR157
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.168.11.5699
– volume: 10
  start-page: 717
  year: 2012
  ident: 64_CR30
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2873
– volume: 191
  start-page: 275
  year: 2000
  ident: 64_CR116
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.191.2.275
– volume: 210
  start-page: 171
  year: 2006
  ident: 64_CR107
  publication-title: Immunol. Rev.
  doi: 10.1111/j.0105-2896.2006.00375.x
– volume: 184
  start-page: 2130
  year: 2010
  ident: 64_CR76
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901528
– volume: 8
  start-page: ra88
  year: 2015
  ident: 64_CR75
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaa5157
– volume: 19
  start-page: 641
  year: 2003
  ident: 64_CR136
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00296-6
– volume: 155
  start-page: 5483
  year: 1995
  ident: 64_CR153
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.155.12.5483
– volume: 183
  start-page: 2444
  year: 2009
  ident: 64_CR204
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0804165
– volume: 8
  start-page: 201
  year: 2005
  ident: 64_CR117
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/ar1857
– volume: 35
  start-page: 3
  year: 2014
  ident: 64_CR19
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2013.09.001
– volume: 86
  start-page: 611
  year: 2015
  ident: 64_CR4
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2015.140520
– volume: 27
  start-page: 2301
  year: 2016
  ident: 64_CR133
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E14-12-1645
– volume: 13
  start-page: 595
  year: 2013
  ident: 64_CR17
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2013.04.005
– volume: 16
  start-page: 354
  year: 2015
  ident: 64_CR231
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3103
– volume: 80
  start-page: 1414
  year: 2009
  ident: 64_CR242
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2009.090015
– volume: 150
  start-page: 286
  year: 2007
  ident: 64_CR246
  publication-title: Br. J. Pharm.
  doi: 10.1038/sj.bjp.0706979
– volume: 82
  start-page: 885
  year: 2011
  ident: 64_CR190
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2010.100425
– volume: 10
  start-page: 1178
  year: 2009
  ident: 64_CR203
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1791
– volume: 148
  start-page: 213
  year: 2012
  ident: 64_CR114
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.031
– volume: 308
  start-page: 1477
  year: 2005
  ident: 64_CR146
  publication-title: Science
  doi: 10.1126/science.1109745
– volume: 34
  start-page: 566
  year: 2011
  ident: 64_CR200
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.03.018
– volume: 40
  start-page: S170
  year: 2013
  ident: 64_CR9
  publication-title: J. Periodontol.
  doi: 10.1111/jcpe.12082
– volume: 28
  start-page: 226
  year: 2003
  ident: 64_CR167
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/S0968-0004(03)00067-7
– volume: 2
  start-page: a000158
  year: 2010
  ident: 64_CR106
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a000158
– volume: 8
  start-page: 247
  year: 2007
  ident: 64_CR169
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1439
– volume: 84
  start-page: 639
  year: 2005
  ident: 64_CR208
  publication-title: J. Dent. Res.
  doi: 10.1177/154405910508400711
– volume: 3
  start-page: 603
  year: 1993
  ident: 64_CR132
  publication-title: Curr. Biol.
  doi: 10.1016/0960-9822(93)90009-D
– volume: 51
  start-page: 261
  year: 2009
  ident: 64_CR57
  publication-title: J. Oral. Sci.
  doi: 10.2334/josnusd.51.261
– volume: 75
  start-page: 116
  year: 2017
  ident: 64_CR3
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12181
– volume: 15
  year: 2017
  ident: 64_CR69
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.2000080
– volume: 106
  start-page: 7119
  year: 2009
  ident: 64_CR36
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0902745106
– volume: 5
  start-page: 511
  year: 2014
  ident: 64_CR119
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00511
– volume: 72
  start-page: 3666
  year: 1975
  ident: 64_CR90
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.72.9.3666
– volume: 89
  start-page: 879
  year: 2010
  ident: 64_CR6
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034510375281
– volume: 114
  start-page: 181
  year: 2003
  ident: 64_CR111
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00521-X
– volume: 2016
  start-page: 9612421
  year: 2016
  ident: 64_CR80
  publication-title: Dis. Markers
– volume: 25
  start-page: 265
  year: 2019
  ident: 64_CR88
  publication-title: Oral. Dis.
  doi: 10.1111/odi.12983
– volume: 1
  start-page: 1
  year: 2019
  ident: 64_CR87
  publication-title: J. Periodontol.
– volume: 32
  start-page: 51
  year: 2014
  ident: 64_CR192
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120257
– volume: 243
  start-page: 159
  year: 2017
  ident: 64_CR24
  publication-title: Tohoku J. Exp. Med.
  doi: 10.1620/tjem.243.159
– volume: 2013
  start-page: 181849
  year: 2013
  ident: 64_CR118
  publication-title: Clin. Dev. Immunol.
  doi: 10.1155/2013/181849
– volume: 12
  start-page: 63
  year: 2016
  ident: 64_CR235
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2015.171
– volume: 378
  start-page: 88
  year: 1995
  ident: 64_CR52
  publication-title: Nature
  doi: 10.1038/378088a0
– volume: 15
  start-page: 93
  year: 2009
  ident: 64_CR215
  publication-title: Oral. Dis.
  doi: 10.1111/j.1601-0825.2008.01497.x
– volume: 259
  start-page: 686
  year: 1984
  ident: 64_CR93
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)43716-1
– volume: 43
  start-page: 727
  year: 2016
  ident: 64_CR81
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12557
– volume: 177
  start-page: 36
  year: 2006
  ident: 64_CR171
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.177.1.36
– volume: 20
  start-page: 260
  year: 2016
  ident: 64_CR58
  publication-title: J. Indian Soc. Periodontol.
  doi: 10.4103/0972-124X.183098
– volume: 8
  start-page: 323
  year: 2014
  ident: 64_CR40
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2014.1724
– volume: 19
  start-page: 2668
  year: 2005
  ident: 64_CR110
  publication-title: Genes Dev.
  doi: 10.1101/gad.1360605
– volume: 35
  start-page: 365
  year: 2008
  ident: 64_CR216
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/j.1600-051X.2008.01212.x
– volume: 80
  start-page: 535
  year: 2009
  ident: 64_CR244
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2009.080447
– volume: 281
  start-page: 6642
  year: 2006
  ident: 64_CR145
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M513118200
– volume: 30
  start-page: 1091
  year: 2003
  ident: 64_CR137
  publication-title: J. Clin. Periodontol.
  doi: 10.1046/j.0303-6979.2003.00435.x
– volume: 239
  start-page: 55
  year: 1988
  ident: 64_CR11
  publication-title: Science
  doi: 10.1126/science.3336774
– volume: 50
  start-page: 812
  year: 2019
  ident: 64_CR66
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.027
– volume: 14
  start-page: 684
  year: 2012
  ident: 64_CR60
  publication-title: Microbes Infect.
  doi: 10.1016/j.micinf.2012.03.002
– volume: 39
  start-page: 294
  year: 2012
  ident: 64_CR160
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2012.03.003
– volume: 50
  start-page: 975
  year: 2019
  ident: 64_CR239
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.018
– volume: 13
  start-page: 465
  year: 2012
  ident: 64_CR26
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2260
– volume: 76
  start-page: 785
  year: 2005
  ident: 64_CR139
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2005.76.5.785
– volume: 39
  start-page: 443
  year: 2013
  ident: 64_CR115
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.06.018
– volume: 10
  start-page: 150
  year: 2017
  ident: 64_CR199
  publication-title: Mucosal. Immunol.
  doi: 10.1038/mi.2016.47
– volume: 15
  start-page: 362
  year: 2015
  ident: 64_CR94
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3834
– volume: 7
  start-page: 307ra155
  year: 2015
  ident: 64_CR185
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aac5380
– volume: 166
  start-page: 4915
  year: 2001
  ident: 64_CR141
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.166.8.4915
– volume: 23
  start-page: 173
  year: 2008
  ident: 64_CR53
  publication-title: Oral. Microbiol. Immunol.
  doi: 10.1111/j.1399-302X.2007.00408.x
– volume: 50
  start-page: 525
  year: 2015
  ident: 64_CR50
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12235
– volume: 201
  start-page: 233
  year: 2005
  ident: 64_CR37
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20041257
– volume: 84
  start-page: 136
  year: 2013
  ident: 64_CR243
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2012.120009
– volume: 385
  start-page: 729
  year: 1997
  ident: 64_CR96
  publication-title: Nature
  doi: 10.1038/385729a0
– volume: 29
  start-page: 71
  year: 2011
  ident: 64_CR196
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-031210-101312
– volume: 25
  start-page: 134
  year: 1998
  ident: 64_CR12
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/j.1600-051X.1998.tb02419.x
– volume: 19
  start-page: 657
  year: 2003
  ident: 64_CR219
  publication-title: Immunity
  doi: 10.1016/S1074-7613(03)00298-X
– volume: 83
  start-page: 362
  year: 2012
  ident: 64_CR45
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2011.110239
– volume: 18
  start-page: 315
  year: 2018
  ident: 64_CR122
  publication-title: J. Evid. Based Dent. Pract.
  doi: 10.1016/j.jebdp.2018.04.001
– volume: 7
  start-page: 479
  year: 2010
  ident: 64_CR5
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/nrcardio.2010.120
– volume: 258
  start-page: 593
  year: 1992
  ident: 64_CR70
  publication-title: Science
  doi: 10.1126/science.1411569
– volume: 43
  start-page: 1040
  year: 2015
  ident: 64_CR174
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.12.003
– volume: 50
  start-page: 892
  year: 2019
  ident: 64_CR163
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.021
– volume: 87
  start-page: 990
  year: 2016
  ident: 64_CR126
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2016.150713
– volume: 24
  start-page: 128
  year: 2019
  ident: 64_CR89
  publication-title: Clin. Exp. Dent. Res
  doi: 10.1002/cre2.162
– volume: 8
  start-page: 1363
  year: 2007
  ident: 64_CR225
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1537
– volume: 103
  start-page: 1345
  year: 1999
  ident: 64_CR155
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI5703
– volume: 20
  start-page: 606
  year: 2016
  ident: 64_CR176
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.10.001
– volume: 50
  start-page: 614
  year: 2015
  ident: 64_CR44
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12241
– volume: 51
  start-page: 549
  year: 2016
  ident: 64_CR121
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12339
– volume: 13
  start-page: 991
  year: 2012
  ident: 64_CR158
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2416
– volume: 69
  start-page: 142
  year: 2015
  ident: 64_CR178
  publication-title: Periodontol 2000
  doi: 10.1111/prd.12083
– volume: 6
  start-page: 31
  year: 2014
  ident: 64_CR240
  publication-title: F1000 Prime Rep.
  doi: 10.12703/P6-31
– volume: 26
  start-page: 229
  year: 2011
  ident: 64_CR14
  publication-title: Mol. Oral. Microbiol
  doi: 10.1111/j.2041-1014.2011.00612.x
– ident: 64_CR2
– volume: 264
  start-page: 17595
  year: 1989
  ident: 64_CR97
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)71533-0
– volume: 169
  start-page: 987
  year: 2006
  ident: 64_CR125
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2006.060180
– volume: 142
  start-page: 460
  year: 2018
  ident: 64_CR166
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2018.03.019
– volume: 11
  start-page: 106
  year: 2004
  ident: 64_CR142
  publication-title: Clin. Diagn. Lab. Immunol.
  doi: 10.1128/CDLI.11.1.106-110.2004
– volume: 180
  start-page: 2752
  year: 2008
  ident: 64_CR227
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.5.2752
– volume: 260
  start-page: 2334
  year: 1985
  ident: 64_CR91
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)89559-X
– volume: 19
  start-page: 997
  year: 2018
  ident: 64_CR229
  publication-title: J. Contemp. Dent. Pr.
  doi: 10.5005/jp-journals-10024-2372
– volume: 98
  start-page: 813
  year: 2019
  ident: 64_CR233
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034519847443
– volume: 281
  start-page: 13636
  year: 2006
  ident: 64_CR103
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M600620200
– volume: 7
  start-page: 738
  year: 2011
  ident: 64_CR7
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2011.106
– volume: 7
  start-page: 1016
  year: 2013
  ident: 64_CR18
  publication-title: ISME J.
  doi: 10.1038/ismej.2012.174
– volume: 2
  start-page: ra63
  year: 2009
  ident: 64_CR168
  publication-title: Sci. Signal.
– volume: 41
  start-page: 748
  year: 2014
  ident: 64_CR22
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12279
– volume: 2019
  start-page: 6034546
  year: 2019
  ident: 64_CR129
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2019/6034546
– volume: 32
  start-page: 227
  year: 2014
  ident: 64_CR238
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120225
– volume: 18
  start-page: 74
  year: 2017
  ident: 64_CR77
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3632
– volume: 20
  start-page: 40
  year: 2019
  ident: 64_CR184
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0249-1
– volume: 6
  start-page: 1123
  year: 2005
  ident: 64_CR156
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1254
– volume: 50
  start-page: 924
  year: 2019
  ident: 64_CR191
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.024
– volume: 374
  start-page: 1
  year: 2003
  ident: 64_CR71
  publication-title: Biochem. J.
  doi: 10.1042/bj20030407
– volume: 70
  start-page: 1143
  year: 1996
  ident: 64_CR217
  publication-title: J. Virol.
  doi: 10.1128/JVI.70.2.1143-1153.1996
– volume: 285
  start-page: 14088
  year: 2010
  ident: 64_CR170
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.017129
– volume: 101
  start-page: 19
  year: 2018
  ident: 64_CR104
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2016.08.027
– volume: 8
  start-page: 1372
  year: 2007
  ident: 64_CR226
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1540
– volume: 9
  start-page: 482
  year: 2010
  ident: 64_CR99
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3030
– volume: 441
  start-page: 235
  year: 2006
  ident: 64_CR79
  publication-title: Nature
  doi: 10.1038/nature04753
– volume: 338
  start-page: 225
  year: 1989
  ident: 64_CR98
  publication-title: Nature
  doi: 10.1038/338225a0
– volume: 15
  start-page: 692
  year: 2015
  ident: 64_CR182
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3908
– volume: 6
  start-page: 727
  year: 2010
  ident: 64_CR8
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2010.139
– volume: 80
  start-page: 2436
  year: 2012
  ident: 64_CR15
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.06276-11
– volume: 133
  start-page: 693
  year: 2008
  ident: 64_CR112
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.036
– volume: 50
  start-page: 851
  year: 2019
  ident: 64_CR130
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.011
– volume: 70
  start-page: 11
  year: 2014
  ident: 64_CR74
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2014.05.024
– volume: 84
  start-page: 683
  year: 2013
  ident: 64_CR127
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2012.120225
– volume: 412
  start-page: 346
  year: 2001
  ident: 64_CR108
  publication-title: Nature
  doi: 10.1038/35085597
– volume: 60
  start-page: 77
  year: 2015
  ident: 64_CR46
  publication-title: Arch. Oral. Biol.
  doi: 10.1016/j.archoralbio.2014.08.021
– volume: 22
  start-page: 120
  year: 2017
  ident: 64_CR181
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.06.014
– volume: 9
  start-page: 1163
  year: 2016
  ident: 64_CR209
  publication-title: Mucosal. Immunol.
  doi: 10.1038/mi.2015.136
– volume: 36
  start-page: 831
  year: 2009
  ident: 64_CR105
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.10.013
– volume: 49
  start-page: 508
  year: 2014
  ident: 64_CR124
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12131
– volume: 50
  start-page: 992
  year: 2019
  ident: 64_CR236
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.017
– volume: 14
  start-page: 585
  year: 2014
  ident: 64_CR173
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3707
– volume: 16
  start-page: 779
  year: 2002
  ident: 64_CR218
  publication-title: Immunity
  doi: 10.1016/S1074-7613(02)00324-2
– volume: 23
  start-page: 1983
  year: 2017
  ident: 64_CR220
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1097/MIB.0000000000001274
– volume: 266
  start-page: 1042
  year: 1994
  ident: 64_CR188
  publication-title: Science
  doi: 10.1126/science.7973658
– volume: 300
  start-page: G568
  year: 2010
  ident: 64_CR222
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00329.2010
– volume: 7
  start-page: 479
  year: 2016
  ident: 64_CR64
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2016.00479
– volume: 387
  start-page: 924
  year: 1997
  ident: 64_CR72
  publication-title: Nature
  doi: 10.1038/43219
– volume: 23
  start-page: 428
  year: 2012
  ident: 64_CR56
  publication-title: Braz. Dent. J.
  doi: 10.1590/S0103-64402012000400020
– volume: 12
  start-page: 9785
  year: 2018
  ident: 64_CR247
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b08976
– volume: 46
  start-page: 592
  year: 2011
  ident: 64_CR54
  publication-title: J. Periodontal Res.
– volume: 9
  year: 2018
  ident: 64_CR234
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05940-9
– volume: 63
  start-page: 45
  year: 2014
  ident: 64_CR23
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-013-0669-1
– volume: 104
  start-page: 1527
  year: 1999
  ident: 64_CR212
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI6910
– volume: 10
  start-page: 497
  year: 2011
  ident: 64_CR16
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2011.10.006
– volume: 6
  start-page: 766
  year: 2018
  ident: 64_CR232
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-17-0498
– volume: 10
  start-page: 857
  year: 2009
  ident: 64_CR78
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1767
– volume: 2012
  start-page: 174764
  year: 2012
  ident: 64_CR213
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2012/174764
– volume: 49
  start-page: 55
  year: 2014
  ident: 64_CR47
  publication-title: J. Periodontal Res.
  doi: 10.1111/jre.12078
– volume: 147
  start-page: 3815
  year: 1991
  ident: 64_CR201
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.147.11.3815
– volume: 189
  start-page: 2079
  year: 2012
  ident: 64_CR224
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1200131
– volume: 27
  start-page: 519
  year: 2009
  ident: 64_CR33
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.021908.132612
– volume: 172
  start-page: 5149
  year: 2004
  ident: 64_CR195
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.172.9.5149
– volume: 41
  start-page: 853
  year: 2014
  ident: 64_CR82
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12286
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Snippet Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local...
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692/699/3020/3029
Alveolar bone
Alveolar Bone Loss - etiology
Bone loss
Cytokines
Cytokines - metabolism
Cytokines - physiology
Dentistry
Dysbacteriosis
Gum disease
Humans
Immune response
Inflammation
Inflammatory diseases
Medicine
Oral and Maxillofacial Surgery
Oral cavity
Orthopedics
Osteoclasts
Periodontal Diseases
Periodontitis
Periodontitis - immunology
Periodontitis - microbiology
Review
Review Article
Surgical Orthopedics
Tumor Necrosis Factor-alpha - physiology
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Title The cytokine network involved in the host immune response to periodontitis
URI https://link.springer.com/article/10.1038/s41368-019-0064-z
https://www.ncbi.nlm.nih.gov/pubmed/31685798
https://www.proquest.com/docview/2311942333
https://www.proquest.com/docview/2312277277
https://pubmed.ncbi.nlm.nih.gov/PMC6828663
Volume 11
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