Prognostic value of serum immunoglobulin A antibodies to pol gene products during HIV‐1 infection

• Published in: Clinical and experimental immunology Vol. 91; no. 2; pp. 237 - 240
• Main Authors: QUESNEL, A., POZZETTO, B., MOJA, P., GRATTARD, F., LUCHT, F. R., TOURAINE, J. L., GAUDIN, O. G., GENIN, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.1993; Blackwell
• Subjects: Adult; AIDS/HIV; Antibody Specificity; Biological and medical sciences; CD4-Positive T-Lymphocytes - immunology; Gene Products, pol - immunology; HIV Antibodies - blood; HIV Infections - immunology; HIV-1 - immunology; HIV‐1; human immunodeficiency virus; Humans; IgA antibodies; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulin A - blood; Immunoglobulin G - blood; Immunopathology; Medical sciences; polymerase CD4+ lymphocytes; Prognosis; Human; Immunopathology; IgA; HIV-1 virus; Antibody; Retroviridae; AIDS; Hemopathy; Serology; Enumeration(counting); Infection; Virus; Specificity; Viral disease; Immunoblotting assay; Lentivirinae; Human immunodeficiency virus; Lymphocyte; ELISA assay
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1111/j.1365-2249.1993.tb05889.x

SUMMARY Serum specimens from 66 HIV‐t‐infected subjects were tested by ELISA for the presence of IgA antibodies to HIV‐t:44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti‐HIV IgA antibodies was studied in relation to the total count of circulating CD4+ lymphocytes and to the level of serum IgA. A significative correlation (P < 0·03) was found between the absence of IgA to the subunit p68 of the reverse transcriptase and a count of CD4+ cell < 400/mm3 or total IgA level over 4–25 g/l. The same pattern was observed for the IgA antibodies to the p52 subunit but the association was just not significant (P < 0·07). No significant decrease was noted for the IgA directed towards the other proteins of HIV‐1, especially the products of the gag gene.