A Cross-Sectional Study of the Relationship between Cortical Bone and High-Impact Activity in Young Adult Males and Females

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 10; pp. 3734 - 3743
• Main Authors: Deere, K, Sayers, A, Rittweger, J, Tobias, J. H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.10.2012; Copyright by The Endocrine Society
• Subjects: Accelerometry; Adiposity - physiology; Adolescent; Biological and medical sciences; Bone Density - physiology; Cross-Sectional Studies; Endocrine Research; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gravitation; Humans; Male; Medical sciences; Motor Activity - physiology; Periosteum - diagnostic imaging; Periosteum - physiology; Regression Analysis; Sex Characteristics; Stress, Mechanical; Tibia - diagnostic imaging; Tibia - physiology; Tomography, X-Ray Computed; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Human; Obesity; Nutrition; Nutrition disorder; Activity; Metabolic diseases; Male; Cross sectional study; Young adult; Female; Endocrinology; Nutritional status; Cortical bone
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2012-1752

Context: The factors that govern skeletal responses to physical activity remain poorly understood. Objective: The aim of this study was to investigate whether gender or fat mass influences relationships between cortical bone and physical activity, after partitioning accelerometer outputs into low (0.5–2.1 g), medium (2.1–4.2 g), or high (>4.2 g) impacts, where g represents gravitational force. Design/Setting: We conducted a cross-sectional analysis in participants from the Avon Longitudinal Study of Parents and Children. Participants: We studied 675 adolescents (272 boys; mean age, 17.7 yr). Outcome Measures: We measured cortical bone parameters from peripheral quantitative computed tomography scans of the mid-tibia, adjusted for height, fat mass, and lean mass. Results: High-impact activity was positively associated with periosteal circumference (PC) in males but not females [coefficients (95% confidence intervals), 0.054 (0.007, 0.100) and 0.07 (−0.028, 0.041), respectively; showing sd change per doubling in activity]. There was also weak evidence that medium impacts were positively related to PC in males but not females (P = 0.03 for gender interaction). On stratifying by fat mass, the positive relationship between high-impact activity and PC was greatest in those with the highest fat mass [high impact vs. PC in males, 0.01 (−0.064, 0.085), 0.045 (−0.040, 0.131), 0.098 (0.012, 0.185), for lower, middle, and upper fat tertiles, respectively; high impact vs. PC in females, −0.041 (−0.101, 0.020), −0.028 (−0.077, 0.022), 0.082 (0.015, 0.148), P = 0.01 for fat mass interaction]. Similar findings were observed for strength parameters, cross-sectional moment of inertia, and strength-strain index. Conclusions: In late adolescence, associations between high-impact activity and PC are attenuated by female gender and low body fat, suggesting that the skeletal response to high-impact activity is particularly reduced in young women with low fat mass.