Effects of dopamine and opioid receptor antagonism on the neural processing of social and nonsocial rewards

• Published in: Human brain mapping Vol. 45; no. 4; pp. e26645 - n/a
• Main Authors: Massaccesi, Claudia, Korb, Sebastian, Götzendorfer, Sebastian, Chiappini, Emilio, Willeit, Matthaeus, Lundström, Johan N., Windischberger, Christian, Eisenegger, Christoph, Silani, Giorgia
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2024
• Subjects: Anatomy; Animal research; Animals; Approach behavior; Blindness; Brain; Brain architecture; Brain research; Dopamine; Dopamine receptors; Drug development; Emotions; fMRI; Food; Humans; Information processing; Magnetic resonance imaging; Medical imaging; Milk; Motivation; Naltrexone; Narcotic Antagonists - pharmacology; Narcotics; Neurochemistry; Neuroimaging; Opioid receptors; opioids; Placebos; Receptors, Opioid; Reinforcement; reward; social touch; Touch; reward; social touch; fMRI; dopamine; food; opioids
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.26645

Rewards are a broad category of stimuli inducing approach behavior to aid survival. Extensive evidence from animal research has shown that wanting (the motivation to pursue a reward) and liking (the pleasure associated with its consumption) are mostly regulated by dopaminergic and opioidergic activity in dedicated brain areas. However, less is known about the neuroanatomy of dopaminergic and opioidergic regulation of reward processing in humans, especially when considering different types of rewards (i.e., social and nonsocial). To fill this gap of knowledge, we combined dopaminergic and opioidergic antagonism (via amisulpride and naltrexone administration) with functional neuroimaging to investigate the neurochemical and neuroanatomical bases of wanting and liking of matched nonsocial (food) and social (interpersonal touch) rewards, using a randomized, between‐subject, placebo‐controlled, double‐blind design. While no drug effect was observed at the behavioral level, brain activity was modulated by the administered compounds. In particular, opioid antagonism, compared to placebo, reduced activity in the medial orbitofrontal cortex during consumption of the most valued social and nonsocial rewards. Dopamine antagonism, however, had no clear effects on brain activity in response to reward anticipation. These findings provide insights into the neurobiology of human reward processing and suggest a similar opioidergic regulation of the neural responses to social and nonsocial reward consumption. Rewards are fundamental for survival but the brain mechanisms underlying human reward processing are not completely understood, especially for social rewards. In this study, we combined pharmacology and functional magnetic resonance imaging (fMRI) to examine the neurochemical and neuroanatomical bases of wanting and liking of matched nonsocial (food) and social (interpersonal touch) rewards. We showed that opioid antagonism reduces liking‐related activity in the medial orbitofrontal cortex when receiving food and touch, suggesting a common opioidergic mechanism underlying the neural representation of the hedonic value of social and nonsocial rewards.