Applications and challenges of low temperature plasma in pharmaceutical field

• Published in: Journal of pharmaceutical analysis Vol. 11; no. 1; pp. 28 - 36
• Main Authors: Gao, Lingge, Shi, Xingmin, Wu, Xili
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.02.2021; School of Public Health,Medical Science Center,Xi'an Jiaotong University,Xi'an,710061,China%Second Affiliated Hospital,Xi'an Jiaotong University,Xi'an,710004,China; Xi'an Jiaotong University; Elsevier
• Subjects: Drug delivery system; Low temperature plasma; Nanodrug; Pharmacy; Plasma-activated liquids; Review Paper; Plasma-activated liquids; Low temperature plasma; Nanodrug; Drug delivery system; Pharmacy
• ISSN: 2095-1779; 2214-0883; 2214-0883
• DOI: 10.1016/j.jpha.2020.05.001

Low temperature plasma (LTP) technology has shown an outstanding application value in the pharmaceutical filed in recent ten years. This paper reviews the research advances in LTP, including its effects on enhancing or inhibiting drug activity, its combined use with drugs to treat cancers, its effects on the improvement of drug delivery system, its use in preparation of new inactivated virus vaccines, its use with mass spectrometry for rapid detection of drug quality, and the anti-tumor and sterilization effects of plasma-activated liquids. The paper also analyzes the challenges of LTP in the pharmaceutical filed, hoping to promote related research. [Display omitted] •Low temperature plasma is a young subject. It shows infinite possibilities in many fields.•Paper introduces the research advances on low temperature plasma in pharmaceutical field for the first time.•Paper summarizes the difficulties in the application of low temperature plasma in pharmacy.