No evidence of intrauterine transmission of hepatitis A virus from a mother to a premature infant

Aim:  To determine whether or not an intrauterine transmission of hepatitis A virus (HAV) occurred from an infected mother to her premature infant delivered by caesarean section. Methods:  The mother and her child were tested for HAV by serology and reverse transcription PCR. Results:  An outbreak o...

Full description

Saved in:
Bibliographic Details
Published inActa Paediatrica Vol. 98; no. 10; pp. 1603 - 1606
Main Authors Selander, Bo, Bläckberg, Jonas, Widell, Anders, Johansson, PJ Hugo
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2009
Blackwell
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Aim:  To determine whether or not an intrauterine transmission of hepatitis A virus (HAV) occurred from an infected mother to her premature infant delivered by caesarean section. Methods:  The mother and her child were tested for HAV by serology and reverse transcription PCR. Results:  An outbreak of HAV infection was seen among children and a 33‐year‐old day‐care teacher, pregnant in third trimester, at a day‐care centre in southern Sweden. Due to premature labour and diminished foetal movements a caesarean section was performed and a premature girl in gestational weeks 33 + 1 was born. During the 3‐week postnatal hospitalization period the child presented no clinical symptoms of HAV infection and anti‐HAV IgM antibodies remained undetectable at day 14 and 109 after birth. Furthermore HAV RNA remained undetectable by reverse transcription PCR in the child’s blood at birth and in throat and faeces for the first 3 and 4 weeks of life respectively. HAV RNA in the mother’s blood was detected at 6 days prior to and at 17 days after delivery. HAV RNA was undetectable in breast milk when tested on day 3 after delivery. Conclusion:  There was no evidence of intrauterine transmission of hepatitis A virus from a viraemic mother to her premature child delivered at gestational week 33 + 1 by caesarean section.
Bibliography:ark:/67375/WNG-SZMLN51S-V
ArticleID:APA1402
istex:E499C3131DC30F00BEAE8A363277D13F2C6E2109
Corrections added after online publication on July 1, 2009: Conclusion in Abstract section has been amended.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0803-5253
1651-2227
1651-2227
DOI:10.1111/j.1651-2227.2009.01402.x