Multistage modeling of lung cancer mortality among arsenic-exposed copper-smelter workers

Multistage modeling incorporating a time-dependent exposure pattern is applied to lung cancer mortality data obtained from a cohort of 2802 arsenic-exposed copper-smelter workers who worked 1 or more years during the period 1940-1964 at a copper smelter at Tacoma, Washington. The workers were follow...

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Bibliographic Details
Published inRisk analysis Vol. 9; no. 4; p. 551
Main Authors Mazumdar, S, Redmond, C K, Enterline, P E, Marsh, G M, Costantino, J P, Zhou, S Y, Patwardhan, R N
Format Journal Article
LanguageEnglish
Published United States 01.12.1989
Subjects
Adult
Aged
Air Pollutants, Occupational - adverse effects
Arsenic - adverse effects
Copper
Epidemiologic Methods
Humans
Lung Neoplasms - chemically induced
Lung Neoplasms - mortality
Male
Middle Aged
Models, Statistical
Occupational Diseases - chemically induced
Occupational Diseases - mortality
Risk Factors
Software
Time Factors
Washington - epidemiology
Washington
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Summary:Multistage modeling incorporating a time-dependent exposure pattern is applied to lung cancer mortality data obtained from a cohort of 2802 arsenic-exposed copper-smelter workers who worked 1 or more years during the period 1940-1964 at a copper smelter at Tacoma, Washington. The workers were followed for death through 1976. There were 100 deaths due to lung cancer during the follow-up period. Exposures to air arsenic levels measured in micrograms/m3 were estimated from departmental air arsenic and workers urinary arsenic measurements. Relationships of different temporal variables with excess death rates are examined to judge qualitatively the implications of the multistage cancer process. Analysis to date indicates a late stage effect of arsenic although an additional early stage effect cannot be ruled out.
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1989.tb01266.x