The connection between transcription and genomic instability

Transcription is a central aspect of DNA metabolism that takes place on the same substrate as replication, repair and recombination Not surprisingly, therefore, there is a physical and functional connection between these processes In recent years, transcription has proven to be a relevant player in...

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Bibliographic Details
Published inThe EMBO journal Vol. 21; no. 3; pp. 195 - 201
Main Author Aguilera, Andrés
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.02.2002
Subjects
Animals
class switching
Genome
Humans
Mutation
Recombination, Genetic
somatic hypermutation
THO complex
Transcription, Genetic
transcription-associated mutation
transcription-associated recombination
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Summary:Transcription is a central aspect of DNA metabolism that takes place on the same substrate as replication, repair and recombination Not surprisingly, therefore, there is a physical and functional connection between these processes In recent years, transcription has proven to be a relevant player in the maintenance of genome integrity and in the induction of genetic instability and diversity The aim of this review is to provide an integrative view on how transcription can control different aspects of genomic integrity, by exploring different mechanisms that might be responsible for transcription‐associated mutation (TAM) and transcription‐associated recombination (TAR).
Bibliography:istex:C4EFB39605CDC3B35B8A1B01D572BEEA0CC63F33
ark:/67375/WNG-F4WZ9HF3-8
ArticleID:EMBJ7594240
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0261-4189
1460-2075
DOI:10.1093/emboj/21.3.195