Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery

• Published in: Angewandte Chemie (International ed.) Vol. 49; no. 21; pp. 3621 - 3626
• Main Authors: Du, Jin-Zhi, Sun, Tian-Meng, Song, Wen-Jing, Wu, Juan, Wang, Jun
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 10.05.2010; WILEY-VCH Verlag; WILEY‐VCH Verlag
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; antitumor agents; charge conversion; drug delivery; Drug Delivery Systems; Gels; Hydrogen-Ion Concentration; Maleic Anhydrides - chemistry; Microscopy, Atomic Force; Molecular Structure; nanoparticles; Nanoparticles - chemistry; pH-responsive; Polymethacrylic Acids - chemistry

A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also en...