Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery

A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also en...

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Published inAngewandte Chemie (International ed.) Vol. 49; no. 21; pp. 3621 - 3626
Main Authors Du, Jin-Zhi, Sun, Tian-Meng, Song, Wen-Jing, Wu, Juan, Wang, Jun
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 10.05.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
antitumor agents
charge conversion
drug delivery
Drug Delivery Systems
Gels
Hydrogen-Ion Concentration
Maleic Anhydrides - chemistry
Microscopy, Atomic Force
Molecular Structure
nanoparticles
Nanoparticles - chemistry
pH-responsive
Polymethacrylic Acids - chemistry
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Summary:A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also enhanced, probably as a result of a decrease in the interaction between the drug and the nanogel in its protonated state.
Bibliography:http://dx.doi.org/10.1002/anie.200907210
ark:/67375/WNG-G0QPVZRJ-1
ArticleID:ANIE200907210
istex:2193F8779CDFEECC8EC2AB588CBBD886D390C781
This research was supported by the National Basic Research Program of China (973 Program 2010CB934000, 2009CB930300), the National Natural Science Foundation of China (20974105, 50733003), and the Key Laboratory of Macromolecular Synthesis and Functionalization of the Ministry of Education, Zhejiang University (2009MSF01).
National Natural Science Foundation of China - No. 20974105; No. 50733003
National Basic Research Program of China - No. 2010CB934000; No. 2009CB930300
Ministry of Education - No. 2009MSF01
These authors contributed equally.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200907210