Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery

A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also en...

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Published in	Angewandte Chemie (International ed.) Vol. 49; no. 21; pp. 3621 - 3626
Main Authors	Du, Jin-Zhi, Sun, Tian-Meng, Song, Wen-Jing, Wu, Juan, Wang, Jun
Format	Journal Article
Language	English
Published	Weinheim Wiley-VCH Verlag 10.05.2010 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics antitumor agents charge conversion drug delivery Drug Delivery Systems Gels Hydrogen-Ion Concentration Maleic Anhydrides - chemistry Microscopy, Atomic Force Molecular Structure nanoparticles Nanoparticles - chemistry pH-responsive Polymethacrylic Acids - chemistry
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Abstract	A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also enhanced, probably as a result of a decrease in the interaction between the drug and the nanogel in its protonated state.
AbstractList	A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also enhanced, probably as a result of a decrease in the interaction between the drug and the nanogel in its protonated state.
Author	Sun, Tian-Meng Wu, Juan Song, Wen-Jing Wang, Jun Du, Jin-Zhi
Author_xml	– sequence: 1 fullname: Du, Jin-Zhi – sequence: 2 fullname: Sun, Tian-Meng – sequence: 3 fullname: Song, Wen-Jing – sequence: 4 fullname: Wu, Juan – sequence: 5 fullname: Wang, Jun
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20391548$$D View this record in MEDLINE/PubMed
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Snippet	A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor... A positive (or negative) chameleon: A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor...
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SubjectTerms	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics antitumor agents charge conversion drug delivery Drug Delivery Systems Gels Hydrogen-Ion Concentration Maleic Anhydrides - chemistry Microscopy, Atomic Force Molecular Structure nanoparticles Nanoparticles - chemistry pH-responsive Polymethacrylic Acids - chemistry
Title	Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery
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