Therapeutic enhancement of vascular-targeted photodynamic therapy by inhibiting proteasomal function

Highlights • PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells. • More accumulation of ubiquitinated proteins and cell apoptosis were induced by PDT in combination with bortezomib. • PDT combined with bortezomib led to enhanced tumor growth inhibit...

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Published inCancer letters Vol. 339; no. 1; pp. 128 - 134
Main Authors Li, Zhuzhu, Agharkar, Priyanka, Chen, Bin
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.10.2013
Elsevier Limited
Subjects
Animals
Apoptosis
Apoptosis - drug effects
Blood Vessels - drug effects
Bortezomib
Cancer
Cancer therapies
Cell growth
Cell Line, Tumor
Cell Survival - drug effects
Combination therapy
Disease Models, Animal
Drug Synergism
endothelial cells
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Hematology, Oncology and Palliative Medicine
Humans
Light
Macular degeneration
Male
Mice
Oxidative stress
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - pharmacology
Porphyrins - administration & dosage
Porphyrins - pharmacology
Prostatic Neoplasms - blood supply
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - metabolism
Proteasome Endopeptidase Complex - metabolism
Proteasome Inhibitors - pharmacology
Protein folding
proteins
reactive oxygen species
Reactive oxygen species (ROS)
Reactive Oxygen Species - metabolism
Studies
therapeutics
Transplantation, Heterologous
Ubiquitination
Ubiquitination - drug effects
Vascular-targeted photodynamic therapy (vPDT)
Verteporfin
Ubiquitination
Bortezomib
Vascular-targeted photodynamic therapy (vPDT)
Reactive oxygen species (ROS)
Verteporfin
Combination therapy
Apoptosis
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Abstract Highlights • PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells. • More accumulation of ubiquitinated proteins and cell apoptosis were induced by PDT in combination with bortezomib. • PDT combined with bortezomib led to enhanced tumor growth inhibition.
AbstractList Vascular-targeted photodynamic therapy (vPDT) is a novel vascular targeting modality based on site-directed delivery of a photosensitizer to tumor vasculature, which induces reactive oxygen species (ROS)-mediated vascular effects upon light activation. To enhance the therapeutic outcome of vPDT, we combined proteasomal inhibitor bortezomib and vPDT using photosensitizer verteporfin in the present study. We found that bortezomib in combination with verteporfin-PDT induced more accumulation of ubiquitinated proteins and apoptosis in endothelial cells than each individual treatment. The combination therapy also enhanced vPDT-induced inhibition in tumor growth. These results indicate that bortezomib can be used together with verteporfin-PDT for enhanced treatment outcome.
•PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells.•More accumulation of ubiquitinated proteins and cell apoptosis were induced by PDT in combination with bortezomib.•PDT combined with bortezomib led to enhanced tumor growth inhibition. Vascular-targeted photodynamic therapy (vPDT) is a novel vascular targeting modality based on site-directed delivery of a photosensitizer to tumor vasculature, which induces reactive oxygen species (ROS)-mediated vascular effects upon light activation. To enhance the therapeutic outcome of vPDT, we combined proteasomal inhibitor bortezomib and vPDT using photosensitizer verteporfin in the present study. We found that bortezomib in combination with verteporfin-PDT induced more accumulation of ubiquitinated proteins and apoptosis in endothelial cells than each individual treatment. The combination therapy also enhanced vPDT-induced inhibition in tumor growth. These results indicate that bortezomib can be used together with verteporfin-PDT for enhanced treatment outcome.
Highlights • PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells. • More accumulation of ubiquitinated proteins and cell apoptosis were induced by PDT in combination with bortezomib. • PDT combined with bortezomib led to enhanced tumor growth inhibition.
Author Chen, Bin
Agharkar, Priyanka
Li, Zhuzhu
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Cites_doi 10.1371/journal.pone.0032972
10.1002/lsm.21108
10.1158/0008-5472.1018.65.3
10.1111/j.1751-1097.1993.tb09577.x
10.1007/s10147-007-0695-5
10.1117/1.2965545
10.1002/lsm.21104
10.1016/j.ijrobp.2004.08.006
10.1111/j.1751-1097.2012.01160.x
10.1517/14656566.2.2.351
10.1038/sj.cdd.4400286
10.1146/annurev-biochem-060310-170328
10.1158/1078-0432.CCR-05-1673
10.1158/1078-0432.720.11.2
10.1038/bjc.1991.18
10.1016/S1535-6108(04)00120-5
10.1136/bjo.2006.090852
10.1038/nature04870
10.1038/sj.cdd.4401427
10.1615/CritRevEukarGeneExpr.v16.i4.10
10.2174/138161211795049660
10.1038/nm940
10.1016/S0002-9440(10)65202-9
10.1002/ijc.26073
10.1111/j.1751-1097.1995.tb05249.x
10.3322/caac.20114
10.1016/j.canlet.2009.08.015
10.1038/sj.bjc.6690448
10.1038/sj.bjc.6605247
10.1158/0008-5472.CAN-08-3439
10.1002/ijc.10175
10.1196/annals.1338.035
10.1007/s11095-008-9604-5
10.1182/blood.V95.1.256
10.1371/journal.pone.0010282
10.1016/S1470-2045(04)01529-3
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Issue 1
Keywords Ubiquitination
Bortezomib
Vascular-targeted photodynamic therapy (vPDT)
Reactive oxygen species (ROS)
Verteporfin
Combination therapy
Apoptosis
Language English
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References Brown, Mellish (b0130) 2001; 2
Luna, Ferrario, Wong, Fisher, Gomer (b0090) 2000; 60
Agostinis, Berg, Cengel, Foster, Girotti, Gollnick, Hahn, Hamblin, Juzeniene, Kessel, Korbelik, Moan, Mroz, Nowis, Piette, Wilson, Golab (b0005) 2011; 61
Chen, Pogue, Hoopes, Hasan (b0020) 2006; 16
Karin (b0185) 2006; 441
Petermeier, Tatar, Inhoffen, Volker, Lafaut, Henke-Fahle, Gelisken, Ziemssen, Bopp, Bartz-Schmidt, Grisanti (b0065) 2006; 90
Xue, Agarwal, Varnes (b0085) 1995; 62
Krammer (b0015) 2001; 21
Granville, Shaw, Leong, Carthy, Margaron, Hunt, McManus (b0060) 1999; 155
Chen, Pogue, Hoopes, Hasan (b0025) 2005; 61
Curry, Levy (b0110) 1993; 58
Peng, Chang, Guo, Wang, Yu, Wu, Jou (b0160) 2005; 1042
Komander, Rape (b0175) 2012; 81
Richter, Waterfield, Jain, Allison, Sternberg, Dolphin, Levy (b0035) 1991; 63
Gross, Gilead, Scherz, Neeman, Salomon (b0045) 2003; 9
Byrne, O’Connor, Hall, Murtagh, O’Neill, Curran, Mongrain, Rousseau, Lecomte, McGee, Callanan, O’Shea, Gallagher (b0055) 2009; 101
Mitra, Giesselman, De Jesus-Andino, Foster (b0105) 2011; 43
Chen, Roskams, Xu, Agostinis, de Witte (b0140) 2002; 98
Madar-Balakirski, Tempel-Brami, Kalchenko, Brenner, Varon, Scherz, Salomon (b0050) 2010; 5
O’Connor, Mc Gee, Likar, Ponomarev, Callanan, O’Shea D, Byrne, Gallagher (b0115) 2012; 130
Chen, Pogue, Luna, Hardman, Hoopes, Hasan (b0030) 2006; 12
Fateye, Li, Wang, Chen (b0135) 2012; 88
Moserova, Kralova (b0120) 2012; 7
Moore, Emberton, Bown (b0145) 2011; 43
Runnels, Chen, Ortel, Kato, Hasan (b0165) 1999; 80
Tobinai (b0125) 2007; 12
Granville, Carthy, Jiang, Levy, McManus, Matroule, Piette, Hunt (b0190) 2000; 95
Szokalska, Makowski, Nowis, Wilczynski, Kujawa, Wojcik, Mlynarczuk-Bialy, Salwa, Bil, Janowska, Agostinis, Verfaillie, Bugajski, Gietka, Issat, Glodkowska, Mrowka, Stoklosa, Hamblin, Mroz, Jakobisiak, Golab (b0075) 2009; 69
Ferrario, Gomer (b0095) 2010; 289
Chen, Pogue, Zhou, O’Hara, Solban, Demidenko, Hoopes, Hasan (b0150) 2005; 11
Johnson, White, Grimaldi (b0180) 2011; 17
Granville, Levy, Hunt (b0155) 1997; 4
Brown, Brown, Walker (b0010) 2004; 5
He, Agharkar, Chen (b0040) 2008; 25
Magi, Ettorre, Liberatori, Bini, Andreassi, Frosali, Neri, Pallini, Di Stefano (b0080) 2004; 11
Adams (b0195) 2004; 5
Korbelik, Sun, Cecic (b0100) 2005; 65
Khurana, Moriyama, Mariampillai, Wilson (b0070) 2008; 13
Belzacq, Jacotot, Vieira, Mistro, Granville, Xie, Reed, Kroemer, Brenner (b0170) 2001; 61
Fateye (10.1016/j.canlet.2013.07.012_b0135) 2012; 88
Chen (10.1016/j.canlet.2013.07.012_b0140) 2002; 98
Adams (10.1016/j.canlet.2013.07.012_b0195) 2004; 5
Granville (10.1016/j.canlet.2013.07.012_b0155) 1997; 4
Krammer (10.1016/j.canlet.2013.07.012_b0015) 2001; 21
Chen (10.1016/j.canlet.2013.07.012_b0020) 2006; 16
Byrne (10.1016/j.canlet.2013.07.012_b0055) 2009; 101
Khurana (10.1016/j.canlet.2013.07.012_b0070) 2008; 13
Chen (10.1016/j.canlet.2013.07.012_b0150) 2005; 11
Gross (10.1016/j.canlet.2013.07.012_b0045) 2003; 9
Granville (10.1016/j.canlet.2013.07.012_b0190) 2000; 95
Runnels (10.1016/j.canlet.2013.07.012_b0165) 1999; 80
Chen (10.1016/j.canlet.2013.07.012_b0025) 2005; 61
Belzacq (10.1016/j.canlet.2013.07.012_b0170) 2001; 61
He (10.1016/j.canlet.2013.07.012_b0040) 2008; 25
Karin (10.1016/j.canlet.2013.07.012_b0185) 2006; 441
Peng (10.1016/j.canlet.2013.07.012_b0160) 2005; 1042
O’Connor (10.1016/j.canlet.2013.07.012_b0115) 2012; 130
Komander (10.1016/j.canlet.2013.07.012_b0175) 2012; 81
Luna (10.1016/j.canlet.2013.07.012_b0090) 2000; 60
Richter (10.1016/j.canlet.2013.07.012_b0035) 1991; 63
Moore (10.1016/j.canlet.2013.07.012_b0145) 2011; 43
Granville (10.1016/j.canlet.2013.07.012_b0060) 1999; 155
Magi (10.1016/j.canlet.2013.07.012_b0080) 2004; 11
Brown (10.1016/j.canlet.2013.07.012_b0130) 2001; 2
Brown (10.1016/j.canlet.2013.07.012_b0010) 2004; 5
Ferrario (10.1016/j.canlet.2013.07.012_b0095) 2010; 289
Agostinis (10.1016/j.canlet.2013.07.012_b0005) 2011; 61
Szokalska (10.1016/j.canlet.2013.07.012_b0075) 2009; 69
Mitra (10.1016/j.canlet.2013.07.012_b0105) 2011; 43
Johnson (10.1016/j.canlet.2013.07.012_b0180) 2011; 17
Chen (10.1016/j.canlet.2013.07.012_b0030) 2006; 12
Curry (10.1016/j.canlet.2013.07.012_b0110) 1993; 58
Tobinai (10.1016/j.canlet.2013.07.012_b0125) 2007; 12
Petermeier (10.1016/j.canlet.2013.07.012_b0065) 2006; 90
Korbelik (10.1016/j.canlet.2013.07.012_b0100) 2005; 65
Madar-Balakirski (10.1016/j.canlet.2013.07.012_b0050) 2010; 5
Xue (10.1016/j.canlet.2013.07.012_b0085) 1995; 62
Moserova (10.1016/j.canlet.2013.07.012_b0120) 2012; 7
References_xml – volume: 21
  start-page: 4271
  year: 2001
  end-page: 4277
  ident: b0015
  article-title: Vascular effects of photodynamic therapy
  publication-title: Anticancer Res.
  contributor:
    fullname: Krammer
– volume: 16
  start-page: 279
  year: 2006
  end-page: 305
  ident: b0020
  article-title: Vascular and cellular targeting for photodynamic therapy
  publication-title: Crit. Rev. Eukaryotic Gene Exp.
  contributor:
    fullname: Hasan
– volume: 7
  start-page: e32972
  year: 2012
  ident: b0120
  article-title: Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways
  publication-title: PloS One
  contributor:
    fullname: Kralova
– volume: 80
  start-page: 946
  year: 1999
  end-page: 953
  ident: b0165
  article-title: BPD-MA-mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells
  publication-title: Br. J. Cancer
  contributor:
    fullname: Hasan
– volume: 17
  start-page: 284
  year: 2011
  end-page: 292
  ident: b0180
  article-title: Stressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas
  publication-title: Curr. Pharm. Des.
  contributor:
    fullname: Grimaldi
– volume: 43
  start-page: 632
  year: 2011
  end-page: 643
  ident: b0105
  article-title: Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70
  publication-title: Lasers Surgery Med.
  contributor:
    fullname: Foster
– volume: 61
  start-page: 1260
  year: 2001
  end-page: 1264
  ident: b0170
  article-title: Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target
  publication-title: Cancer Res.
  contributor:
    fullname: Brenner
– volume: 63
  start-page: 87
  year: 1991
  end-page: 93
  ident: b0035
  article-title: Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model
  publication-title: Br. J. Cancer
  contributor:
    fullname: Levy
– volume: 2
  start-page: 351
  year: 2001
  end-page: 361
  ident: b0130
  article-title: Verteporfin: a milestone in opthalmology and photodynamic therapy
  publication-title: Exp. Opin. Pharmacother
  contributor:
    fullname: Mellish
– volume: 62
  start-page: 135
  year: 1995
  end-page: 143
  ident: b0085
  article-title: Elevation of GRP-78 and loss of HSP-70 following photodynamic treatment of V79 cells: sensitization by nigericin
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Varnes
– volume: 4
  start-page: 623
  year: 1997
  end-page: 628
  ident: b0155
  article-title: Photodynamic therapy induces caspase-3 activation in HL-60 cells
  publication-title: Cell Death Differ.
  contributor:
    fullname: Hunt
– volume: 11
  start-page: 842
  year: 2004
  end-page: 852
  ident: b0080
  article-title: Selectivity of protein carbonylation in the apoptotic response to oxidative stress associated with photodynamic therapy: a cell biochemical and proteomic investigation
  publication-title: Cell Death Differ.
  contributor:
    fullname: Di Stefano
– volume: 130
  start-page: 705
  year: 2012
  end-page: 715
  ident: b0115
  article-title: Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo
  publication-title: Int. J. Cancer
  contributor:
    fullname: Gallagher
– volume: 5
  start-page: 417
  year: 2004
  end-page: 421
  ident: b0195
  article-title: The development of proteasome inhibitors as anticancer drugs
  publication-title: Cancer Cell
  contributor:
    fullname: Adams
– volume: 5
  start-page: 497
  year: 2004
  end-page: 508
  ident: b0010
  article-title: The present and future role of photodynamic therapy in cancer treatment
  publication-title: Lancet. Oncol.
  contributor:
    fullname: Walker
– volume: 1042
  start-page: 419
  year: 2005
  end-page: 428
  ident: b0160
  article-title: Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis
  publication-title: Ann. NY Acad. Sci.
  contributor:
    fullname: Jou
– volume: 12
  start-page: 917
  year: 2006
  end-page: 923
  ident: b0030
  article-title: Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications
  publication-title: Clin. Cancer Res.
  contributor:
    fullname: Hasan
– volume: 101
  start-page: 1565
  year: 2009
  end-page: 1573
  ident: b0055
  article-title: Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment
  publication-title: Br. J. Cancer
  contributor:
    fullname: Gallagher
– volume: 441
  start-page: 431
  year: 2006
  end-page: 436
  ident: b0185
  article-title: Nuclear factor-kappaB in cancer development and progression
  publication-title: Nature
  contributor:
    fullname: Karin
– volume: 90
  start-page: 1034
  year: 2006
  end-page: 1039
  ident: b0065
  article-title: Verteporfin photodynamic therapy induced apoptosis in choroidal neovascular membranes
  publication-title: Br. J. Ophthalmol.
  contributor:
    fullname: Grisanti
– volume: 11
  start-page: 720
  year: 2005
  end-page: 727
  ident: b0150
  article-title: Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model
  publication-title: Clin. Cancer Res.
  contributor:
    fullname: Hasan
– volume: 5
  start-page: e10282
  year: 2010
  ident: b0050
  article-title: Permanent occlusion of feeding arteries and draining veins in solid mouse tumors by vascular targeted photodynamic therapy (VTP) with Tookad
  publication-title: PloS one
  contributor:
    fullname: Salomon
– volume: 88
  start-page: 1265
  year: 2012
  end-page: 1272
  ident: b0135
  article-title: Combination of phosphatidylinositol 3-kinases pathway inhibitor and photodynamic therapy in endothelial and tumor cells
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Chen
– volume: 61
  start-page: 1216
  year: 2005
  end-page: 1226
  ident: b0025
  article-title: Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy
  publication-title: Int. J. Radiat. Oncol. Biol. Phys.
  contributor:
    fullname: Hasan
– volume: 25
  start-page: 1873
  year: 2008
  end-page: 1880
  ident: b0040
  article-title: Intravital microscopic analysis of vascular perfusion and macromolecule extravasation after photodynamic vascular targeting therapy
  publication-title: Pharm. Res.
  contributor:
    fullname: Chen
– volume: 43
  start-page: 768
  year: 2011
  end-page: 775
  ident: b0145
  article-title: Photodynamic therapy for prostate cancer – an emerging approach for organ-confined disease
  publication-title: Lasers Surgery Med.
  contributor:
    fullname: Bown
– volume: 12
  start-page: 318
  year: 2007
  end-page: 326
  ident: b0125
  article-title: Proteasome inhibitor, bortezomib, for myeloma and lymphoma
  publication-title: Int. J. Clin. Oncol.
  contributor:
    fullname: Tobinai
– volume: 98
  start-page: 284
  year: 2002
  end-page: 290
  ident: b0140
  article-title: Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model
  publication-title: Int. J. Cancer
  contributor:
    fullname: de Witte
– volume: 60
  start-page: 1637
  year: 2000
  end-page: 1644
  ident: b0090
  article-title: Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter
  publication-title: Cancer Res.
  contributor:
    fullname: Gomer
– volume: 58
  start-page: 374
  year: 1993
  end-page: 379
  ident: b0110
  article-title: Stress protein expression in murine tumor cells following photodynamic therapy with benzoporphyrin derivative
  publication-title: Photochem. Photobiol.
  contributor:
    fullname: Levy
– volume: 61
  start-page: 250
  year: 2011
  end-page: 281
  ident: b0005
  article-title: Photodynamic therapy of cancer: an update
  publication-title: CA Cancer J. Clin.
  contributor:
    fullname: Golab
– volume: 13
  start-page: 040502
  year: 2008
  ident: b0070
  article-title: Intravital high-resolution optical imaging of individual vessel response to photodynamic treatment
  publication-title: J. Biomed. Opt.
  contributor:
    fullname: Wilson
– volume: 95
  start-page: 256
  year: 2000
  end-page: 262
  ident: b0190
  article-title: Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin
  publication-title: Blood
  contributor:
    fullname: Hunt
– volume: 155
  start-page: 1021
  year: 1999
  end-page: 1025
  ident: b0060
  article-title: Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis
  publication-title: Am. J. Pathol.
  contributor:
    fullname: McManus
– volume: 81
  start-page: 203
  year: 2012
  end-page: 229
  ident: b0175
  article-title: The ubiquitin code
  publication-title: Ann. Rev. Biochem.
  contributor:
    fullname: Rape
– volume: 289
  start-page: 188
  year: 2010
  end-page: 194
  ident: b0095
  article-title: Targeting the 90 kDa heat shock protein improves photodynamic therapy
  publication-title: Cancer Lett.
  contributor:
    fullname: Gomer
– volume: 65
  start-page: 1018
  year: 2005
  end-page: 1026
  ident: b0100
  article-title: Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response
  publication-title: Cancer Res.
  contributor:
    fullname: Cecic
– volume: 9
  start-page: 1327
  year: 2003
  end-page: 1331
  ident: b0045
  article-title: Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI
  publication-title: Nat. Med.
  contributor:
    fullname: Salomon
– volume: 69
  start-page: 4235
  year: 2009
  end-page: 4243
  ident: b0075
  article-title: Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response
  publication-title: Cancer Res.
  contributor:
    fullname: Golab
– volume: 7
  start-page: e32972
  year: 2012
  ident: 10.1016/j.canlet.2013.07.012_b0120
  article-title: Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways
  publication-title: PloS One
  doi: 10.1371/journal.pone.0032972
  contributor:
    fullname: Moserova
– volume: 43
  start-page: 632
  year: 2011
  ident: 10.1016/j.canlet.2013.07.012_b0105
  article-title: Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70
  publication-title: Lasers Surgery Med.
  doi: 10.1002/lsm.21108
  contributor:
    fullname: Mitra
– volume: 65
  start-page: 1018
  year: 2005
  ident: 10.1016/j.canlet.2013.07.012_b0100
  article-title: Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.1018.65.3
  contributor:
    fullname: Korbelik
– volume: 58
  start-page: 374
  year: 1993
  ident: 10.1016/j.canlet.2013.07.012_b0110
  article-title: Stress protein expression in murine tumor cells following photodynamic therapy with benzoporphyrin derivative
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.1993.tb09577.x
  contributor:
    fullname: Curry
– volume: 12
  start-page: 318
  year: 2007
  ident: 10.1016/j.canlet.2013.07.012_b0125
  article-title: Proteasome inhibitor, bortezomib, for myeloma and lymphoma
  publication-title: Int. J. Clin. Oncol.
  doi: 10.1007/s10147-007-0695-5
  contributor:
    fullname: Tobinai
– volume: 13
  start-page: 040502
  year: 2008
  ident: 10.1016/j.canlet.2013.07.012_b0070
  article-title: Intravital high-resolution optical imaging of individual vessel response to photodynamic treatment
  publication-title: J. Biomed. Opt.
  doi: 10.1117/1.2965545
  contributor:
    fullname: Khurana
– volume: 43
  start-page: 768
  year: 2011
  ident: 10.1016/j.canlet.2013.07.012_b0145
  article-title: Photodynamic therapy for prostate cancer – an emerging approach for organ-confined disease
  publication-title: Lasers Surgery Med.
  doi: 10.1002/lsm.21104
  contributor:
    fullname: Moore
– volume: 61
  start-page: 1216
  year: 2005
  ident: 10.1016/j.canlet.2013.07.012_b0025
  article-title: Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy
  publication-title: Int. J. Radiat. Oncol. Biol. Phys.
  doi: 10.1016/j.ijrobp.2004.08.006
  contributor:
    fullname: Chen
– volume: 88
  start-page: 1265
  year: 2012
  ident: 10.1016/j.canlet.2013.07.012_b0135
  article-title: Combination of phosphatidylinositol 3-kinases pathway inhibitor and photodynamic therapy in endothelial and tumor cells
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.2012.01160.x
  contributor:
    fullname: Fateye
– volume: 2
  start-page: 351
  year: 2001
  ident: 10.1016/j.canlet.2013.07.012_b0130
  article-title: Verteporfin: a milestone in opthalmology and photodynamic therapy
  publication-title: Exp. Opin. Pharmacother
  doi: 10.1517/14656566.2.2.351
  contributor:
    fullname: Brown
– volume: 4
  start-page: 623
  year: 1997
  ident: 10.1016/j.canlet.2013.07.012_b0155
  article-title: Photodynamic therapy induces caspase-3 activation in HL-60 cells
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4400286
  contributor:
    fullname: Granville
– volume: 61
  start-page: 1260
  year: 2001
  ident: 10.1016/j.canlet.2013.07.012_b0170
  article-title: Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target
  publication-title: Cancer Res.
  contributor:
    fullname: Belzacq
– volume: 81
  start-page: 203
  year: 2012
  ident: 10.1016/j.canlet.2013.07.012_b0175
  article-title: The ubiquitin code
  publication-title: Ann. Rev. Biochem.
  doi: 10.1146/annurev-biochem-060310-170328
  contributor:
    fullname: Komander
– volume: 12
  start-page: 917
  year: 2006
  ident: 10.1016/j.canlet.2013.07.012_b0030
  article-title: Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-05-1673
  contributor:
    fullname: Chen
– volume: 11
  start-page: 720
  year: 2005
  ident: 10.1016/j.canlet.2013.07.012_b0150
  article-title: Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.720.11.2
  contributor:
    fullname: Chen
– volume: 21
  start-page: 4271
  year: 2001
  ident: 10.1016/j.canlet.2013.07.012_b0015
  article-title: Vascular effects of photodynamic therapy
  publication-title: Anticancer Res.
  contributor:
    fullname: Krammer
– volume: 63
  start-page: 87
  year: 1991
  ident: 10.1016/j.canlet.2013.07.012_b0035
  article-title: Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1991.18
  contributor:
    fullname: Richter
– volume: 5
  start-page: 417
  year: 2004
  ident: 10.1016/j.canlet.2013.07.012_b0195
  article-title: The development of proteasome inhibitors as anticancer drugs
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(04)00120-5
  contributor:
    fullname: Adams
– volume: 90
  start-page: 1034
  year: 2006
  ident: 10.1016/j.canlet.2013.07.012_b0065
  article-title: Verteporfin photodynamic therapy induced apoptosis in choroidal neovascular membranes
  publication-title: Br. J. Ophthalmol.
  doi: 10.1136/bjo.2006.090852
  contributor:
    fullname: Petermeier
– volume: 441
  start-page: 431
  year: 2006
  ident: 10.1016/j.canlet.2013.07.012_b0185
  article-title: Nuclear factor-kappaB in cancer development and progression
  publication-title: Nature
  doi: 10.1038/nature04870
  contributor:
    fullname: Karin
– volume: 11
  start-page: 842
  year: 2004
  ident: 10.1016/j.canlet.2013.07.012_b0080
  article-title: Selectivity of protein carbonylation in the apoptotic response to oxidative stress associated with photodynamic therapy: a cell biochemical and proteomic investigation
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4401427
  contributor:
    fullname: Magi
– volume: 16
  start-page: 279
  year: 2006
  ident: 10.1016/j.canlet.2013.07.012_b0020
  article-title: Vascular and cellular targeting for photodynamic therapy
  publication-title: Crit. Rev. Eukaryotic Gene Exp.
  doi: 10.1615/CritRevEukarGeneExpr.v16.i4.10
  contributor:
    fullname: Chen
– volume: 17
  start-page: 284
  year: 2011
  ident: 10.1016/j.canlet.2013.07.012_b0180
  article-title: Stressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/138161211795049660
  contributor:
    fullname: Johnson
– volume: 9
  start-page: 1327
  year: 2003
  ident: 10.1016/j.canlet.2013.07.012_b0045
  article-title: Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI
  publication-title: Nat. Med.
  doi: 10.1038/nm940
  contributor:
    fullname: Gross
– volume: 155
  start-page: 1021
  year: 1999
  ident: 10.1016/j.canlet.2013.07.012_b0060
  article-title: Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)65202-9
  contributor:
    fullname: Granville
– volume: 130
  start-page: 705
  year: 2012
  ident: 10.1016/j.canlet.2013.07.012_b0115
  article-title: Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.26073
  contributor:
    fullname: O’Connor
– volume: 62
  start-page: 135
  year: 1995
  ident: 10.1016/j.canlet.2013.07.012_b0085
  article-title: Elevation of GRP-78 and loss of HSP-70 following photodynamic treatment of V79 cells: sensitization by nigericin
  publication-title: Photochem. Photobiol.
  doi: 10.1111/j.1751-1097.1995.tb05249.x
  contributor:
    fullname: Xue
– volume: 61
  start-page: 250
  year: 2011
  ident: 10.1016/j.canlet.2013.07.012_b0005
  article-title: Photodynamic therapy of cancer: an update
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.20114
  contributor:
    fullname: Agostinis
– volume: 289
  start-page: 188
  year: 2010
  ident: 10.1016/j.canlet.2013.07.012_b0095
  article-title: Targeting the 90 kDa heat shock protein improves photodynamic therapy
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2009.08.015
  contributor:
    fullname: Ferrario
– volume: 80
  start-page: 946
  year: 1999
  ident: 10.1016/j.canlet.2013.07.012_b0165
  article-title: BPD-MA-mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6690448
  contributor:
    fullname: Runnels
– volume: 101
  start-page: 1565
  year: 2009
  ident: 10.1016/j.canlet.2013.07.012_b0055
  article-title: Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6605247
  contributor:
    fullname: Byrne
– volume: 69
  start-page: 4235
  year: 2009
  ident: 10.1016/j.canlet.2013.07.012_b0075
  article-title: Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-3439
  contributor:
    fullname: Szokalska
– volume: 98
  start-page: 284
  year: 2002
  ident: 10.1016/j.canlet.2013.07.012_b0140
  article-title: Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.10175
  contributor:
    fullname: Chen
– volume: 60
  start-page: 1637
  year: 2000
  ident: 10.1016/j.canlet.2013.07.012_b0090
  article-title: Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter
  publication-title: Cancer Res.
  contributor:
    fullname: Luna
– volume: 1042
  start-page: 419
  year: 2005
  ident: 10.1016/j.canlet.2013.07.012_b0160
  article-title: Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis
  publication-title: Ann. NY Acad. Sci.
  doi: 10.1196/annals.1338.035
  contributor:
    fullname: Peng
– volume: 25
  start-page: 1873
  year: 2008
  ident: 10.1016/j.canlet.2013.07.012_b0040
  article-title: Intravital microscopic analysis of vascular perfusion and macromolecule extravasation after photodynamic vascular targeting therapy
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-008-9604-5
  contributor:
    fullname: He
– volume: 95
  start-page: 256
  year: 2000
  ident: 10.1016/j.canlet.2013.07.012_b0190
  article-title: Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin
  publication-title: Blood
  doi: 10.1182/blood.V95.1.256
  contributor:
    fullname: Granville
– volume: 5
  start-page: e10282
  year: 2010
  ident: 10.1016/j.canlet.2013.07.012_b0050
  article-title: Permanent occlusion of feeding arteries and draining veins in solid mouse tumors by vascular targeted photodynamic therapy (VTP) with Tookad
  publication-title: PloS one
  doi: 10.1371/journal.pone.0010282
  contributor:
    fullname: Madar-Balakirski
– volume: 5
  start-page: 497
  year: 2004
  ident: 10.1016/j.canlet.2013.07.012_b0010
  article-title: The present and future role of photodynamic therapy in cancer treatment
  publication-title: Lancet. Oncol.
  doi: 10.1016/S1470-2045(04)01529-3
  contributor:
    fullname: Brown
SSID ssj0005475
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Snippet Highlights • PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells. • More accumulation of ubiquitinated...
•PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells.•More accumulation of ubiquitinated proteins and cell...
Vascular-targeted photodynamic therapy (vPDT) is a novel vascular targeting modality based on site-directed delivery of a photosensitizer to tumor vasculature,...
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StartPage 128
SubjectTerms Animals
Apoptosis
Apoptosis - drug effects
Blood Vessels - drug effects
Bortezomib
Cancer
Cancer therapies
Cell growth
Cell Line, Tumor
Cell Survival - drug effects
Combination therapy
Disease Models, Animal
Drug Synergism
endothelial cells
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Hematology, Oncology and Palliative Medicine
Humans
Light
Macular degeneration
Male
Mice
Oxidative stress
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - pharmacology
Porphyrins - administration & dosage
Porphyrins - pharmacology
Prostatic Neoplasms - blood supply
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - metabolism
Proteasome Endopeptidase Complex - metabolism
Proteasome Inhibitors - pharmacology
Protein folding
proteins
reactive oxygen species
Reactive oxygen species (ROS)
Reactive Oxygen Species - metabolism
Studies
therapeutics
Transplantation, Heterologous
Ubiquitination
Ubiquitination - drug effects
Vascular-targeted photodynamic therapy (vPDT)
Verteporfin
Title Therapeutic enhancement of vascular-targeted photodynamic therapy by inhibiting proteasomal function
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https://dx.doi.org/10.1016/j.canlet.2013.07.012
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