Therapeutic enhancement of vascular-targeted photodynamic therapy by inhibiting proteasomal function

• Published in: Cancer letters Vol. 339; no. 1; pp. 128 - 134
• Main Authors: Li, Zhuzhu, Agharkar, Priyanka, Chen, Bin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.10.2013; Elsevier Limited
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Blood Vessels - drug effects; Bortezomib; Cancer; Cancer therapies; Cell growth; Cell Line, Tumor; Cell Survival - drug effects; Combination therapy; Disease Models, Animal; Drug Synergism; endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Hematology, Oncology and Palliative Medicine; Humans; Light; Macular degeneration; Male; Mice; Oxidative stress; Photochemotherapy; Photodynamic therapy; Photosensitizing Agents - administration & dosage; Photosensitizing Agents - pharmacology; Porphyrins - administration & dosage; Porphyrins - pharmacology; Prostatic Neoplasms - blood supply; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors - pharmacology; Protein folding; proteins; reactive oxygen species; Reactive oxygen species (ROS); Reactive Oxygen Species - metabolism; Studies; therapeutics; Transplantation, Heterologous; Ubiquitination; Ubiquitination - drug effects; Vascular-targeted photodynamic therapy (vPDT); Verteporfin; Ubiquitination; Bortezomib; Vascular-targeted photodynamic therapy (vPDT); Reactive oxygen species (ROS); Verteporfin; Combination therapy; Apoptosis
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2013.07.012

Highlights • PDT with verteporfin caused ROS production, protein ubiquitination and apoptosis in endothelial cells. • More accumulation of ubiquitinated proteins and cell apoptosis were induced by PDT in combination with bortezomib. • PDT combined with bortezomib led to enhanced tumor growth inhibition.