CD34 positive cells as endothelial progenitor cells in biology and medicine
CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34 cells has attracted interest for application in patient...
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Published in | Frontiers in cell and developmental biology Vol. 11; p. 1128134 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
17.04.2023
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Subjects | |
Online Access | Get full text |
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Summary: | CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34
cells has attracted interest for application in patients with various vascular, ischemic, and inflammatory diseases. CD34
cells have recently been reported to improve therapeutic angiogenesis in a variety of diseases. Mechanistically, CD34
cells are involved in both direct incorporation into the expanding vasculature and paracrine activity through angiogenesis, anti-inflammatory, immunomodulatory, and anti-apoptosis/fibrosis roles, which support the developing microvasculature. Preclinical, pilot, and clinical trials have well documented a track record of safety, practicality, and validity of CD34
cell therapy in various diseases. However, the clinical application of CD34
cell therapy has triggered scientific debates and controversies in last decade. This review covers all preexisting scientific literature and prepares an overview of the comprehensive biology of CD34
cells as well as the preclinical/clinical details of CD34
cell therapy for regenerative medicine. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Maxime Jeljeli, Beth Israel Deaconess Medical Center and Harvard Medical School, United States Edited by: David M. Smadja, Université Paris Cité, France Reviewed by: Neslihan Meriç, Kutahya Health Sciences University, Türkiye |
ISSN: | 2296-634X 2296-634X |
DOI: | 10.3389/fcell.2023.1128134 |