Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life
The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (meta...
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Published in | Gut microbes Vol. 15; no. 1; p. 2192151 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Taylor & Francis
31.12.2023
Taylor & Francis Group |
Subjects | |
Online Access | Get full text |
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Summary: | The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1949-0976 1949-0984 |
DOI: | 10.1080/19490976.2023.2192151 |