Naphthalecin, a Novel Antibiotic Produced by the Anaerobic Bacterium, Sporotalea colonica sp. nov

• Published in: Journal of antibiotics Vol. 61; no. 4; pp. 207 - 212
• Main Authors: Ezaki, Masami, Muramatsu, Hideyuki, Takase, Shigehiro, Hashimoto, Michizane, Nagai, Koji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2008; Japan Antibiotics Research Assoc; Nature Publishing Group
• Subjects: Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Bacteria; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Immunology; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Microbiology; Naphthalene; Naphthols - blood; Naphthols - chemistry; Naphthols - isolation & purification; Naphthols - pharmacology; Organic Chemistry; original-article; Pharmacology & Pharmacy; Phylogeny; Science & Technology; Veillonellaceae - classification; Veillonellaceae - metabolism; antibacterial antibiotic; strictly anaerobic bacteria; naphthalene; naphthalecin; Sporotalea colonica
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2008.30

A novel antibiotic naphthalecin was purified and isolated from the cells of an anaerobic bacterium isolated from a soil sample. This antibiotic contained a naphthalene moiety, so named as naphthalecin, and showed antibacterial activity against gram positive species. The producing strain, an obligate anaerobe, was identified as a new species of the genus Sporotalea . Identification of the bacterium, cultivation, purification, structure determination, and antibacterial activity are shown.