Novel lysophosphoplipid receptors: their structure and function

• Published in: Journal of lipid research Vol. 55; no. 10; pp. 1986 - 1995
• Main Authors: Makide, Kumiko, Uwamizu, Akiharu, Shinjo, Yuji, Ishiguro, Jun, Okutani, Michiyo, Inoue, Asuka, Aoki, Junken
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2014; The American Society for Biochemistry and Molecular Biology; Elsevier
• Series: Thematic Review Series: Lysophospholipids and their Receptors
• Subjects: Animals; GPCR; Humans; LPI; Lysophospholipids - chemistry; Lysophospholipids - metabolism; LysoPS; Receptors, Lysophospholipid - chemistry; Receptors, Lysophospholipid - genetics; Receptors, Lysophospholipid - metabolism; Structure-Activity Relationship; Thematic Review; LPI; GPCR; LysoPS
• ISSN: 0022-2275; 1539-7262
• DOI: 10.1194/jlr.R046920

It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid. While the roles of some LysoGPs, such as lysophosphatidic acid and sphingosine 1-phosphate, have been thoroughly examined, little is known about the roles of several other LysoGPs, such as lysophosphatidylserine (LysoPS), lysophosphatidylthreonine, lysophosphatidylethanolamine, lysophosphatidylinositol (LPI), and lysophosphatidylglycerol. Recently, a GPCR was found for LPI (GPR55) and three GPCRs (GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3) were found for LysoPS. In this review, we focus on these newly identified GPCRs and summarize the actions of LysoPS and LPI as lipid mediators.