Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts - Crucial 'Human Osteoclastology'

Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit murine osteoclastogenesis and murine arthritis models , but not the destruction of...

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Bibliographic Details
Published inPharmaceuticals Vol. 3; no. 5; pp. 1394 - 1410
Main Authors Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 11.05.2010
MDPI
Subjects
interleukin-17 (IL-17)
non-steroidal anti-inflammatory drugs (NSAIDs)
osteo-clastogenesis
osteoclast
osteoclastology
prostaglandin E2 (PGE2)
Review
interleukin-17 (IL-17)
non-steroidal anti-inflammatory drugs (NSAIDs)
osteo-clastogenesis
prostaglandin E2 (PGE2)
osteoclast
osteoclastology
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Summary:Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit murine osteoclastogenesis and murine arthritis models , but not the destruction of joints of patients with rheumatoid arthritis. In the current review article, we review the recent findings in the effect of NSAIDs on the formation and function of human and murine osteoclasts both and , underlining the importance of studies using human osteoclasts. Since 2009, we have suggested a novel term 'human osteoclastology'.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1424-8247
1424-8247
DOI:10.3390/ph3051394