Myrsinoic acids B, C and F, anti-inflammatory compounds from Myrsine seguinii

• Published in: Bioscience, biotechnology, and biochemistry Vol. 66; no. 3; pp. 655 - 659
• Main Authors: Hirota, M. (Shinshu Univ., Minamiminowa, Nagano (Japan). Faculty of Agriculture), Miyazaki, S, Minakuchi, T, Takagi, T, Shibata, H
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.03.2002; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Alkenes - chemistry; Alkenes - isolation & purification; Alkenes - pharmacology; Animals; anti-inflammatory; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; ANTIINFLAMMATORY AGENTS; Benzofurans - chemistry; Benzofurans - isolation & purification; Benzofurans - pharmacology; Biological and medical sciences; Chromans - chemistry; Chromans - isolation & purification; Chromans - pharmacology; General pharmacology; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; MICE; MYRSINACEAE; Myrsine seguinii; OEDEMA; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Leaves - chemistry; Plant Stems - chemistry; Plants, Medicinal - chemistry; Primulaceae - chemistry; Spectrophotometry, Infrared; TPA-induced edema; Molecular structure; Rodentia; Antiinflammatory agent; Extract; Foil; Biological activity; Vertebrata; Plant; Mammalia; Treatment; Mouse; Dicotyledones; Animal; Angiospermae; Plant origin; Isolation; Spermatophyta; Phytotherapy; Myrsinaceae; Structural analysis
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.66.655

The methanolic extract of Myrsine seguinii yielded three anti-inflammatory compounds, myrsinoic acids B, C and F, and their structures were elucidated from the spectroscopic data. These compounds suppressed the TPA-induced edema of mouse ear, myrsinoic acid F beingjhe most active (IE 77% at a dose of 0.56micro mol).