Effects of a Prolonged Booster Interval on Neutralization of Omicron Variant

In a study involving recipients of the Chinese inactivated vaccines and the ZF2001 protein subunit vaccine, neutralizing antibody titers were higher when the interval between the second and third dose was 5 months rather than 1 month. Among the ZF2001 recipients in the prolonged-interval group, near...

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Published inNew England Journal of Medicine Vol. 386; no. 9; pp. 894 - 896
Main Authors Zhao, Xin, Li, Dedong, Ruan, Wenjing, Chen, Zhihai, Zhang, Rong, Zheng, Anqi, Qiao, Shitong, Zheng, Xinlei, Zhao, Yingze, Dai, Lianpan, Han, Pengcheng, Gao, George F
Format Journal Article Web Resource
LanguageEnglish
Published United States Massachusetts Medical Society 03.03.2022
Subjects
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
China
Convalescence
Coronavirus
Coronaviruses
Correspondence
COVID-19 Serological Testing
COVID-19 vaccines
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Humans
Immunization, Secondary
Immunogenicity, Vaccine
Immunoglobulin G - blood
Infectious Disease
Proteins
R&D
Research & development
SARS-CoV-2 - immunology
Science
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viral Infections
China
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Summary:In a study involving recipients of the Chinese inactivated vaccines and the ZF2001 protein subunit vaccine, neutralizing antibody titers were higher when the interval between the second and third dose was 5 months rather than 1 month. Among the ZF2001 recipients in the prolonged-interval group, nearly 70% had neutralizing antibodies to the omicron variant 4 to 6 months after the third dose.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
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ObjectType-Correspondence-1
Dr. X. Zhao, Mr. Li, Ms. Ruan, and Mr. Chen contributed equally to this letter.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2119426