VERITAS: Harnessing the power of nomenclature in biologic discovery

We are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision. Therefore, considering even a dozen such formats, in combinatio...

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Published inmAbs Vol. 15; no. 1; p. 2207232
Main Authors Biswas, Riti, Belouski, Ed, Graham, Kevin, Hortter, Michelle, Mock, Marissa, Tinberg, Christine E., Russell, Alan J.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 31.12.2023
Taylor & Francis Group
Subjects
Antibodies, Bispecific
Antibody engineering
antibody formats
antibody nomenclature
Biological Products
bispecific antibodies
Drug Development
Drug Discovery
Humans
multispecific antibodies
Rapid Communication
therapeutic antibodies
antibody formats
multispecific antibodies
antibody nomenclature
Antibody engineering
therapeutic antibodies
bispecific antibodies
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Summary:We are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision. Therefore, considering even a dozen such formats, in combination with hundreds of possible targets, can create confusion and increase the complexity of drug discovery. To address this challenge, we introduce Verified Taxonomy for Antibodies (VERITAS). This classification and nomenclature scheme is extensible to multispecific therapeutic formats and beyond. VERITAS names are easy to understand while drawing direct connections to the structure of a given format, with or without specific target information, making these names useful to adopt in scientific discourse and as inputs to machine learning algorithms for drug development.
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ISSN:1942-0862
1942-0870
DOI:10.1080/19420862.2023.2207232