Multipotent mesenchymal stromal cells are fully permissive for human cytomegalovirus infection

• Published in: Virologica Sinica Vol. 31; no. 3; pp. 219 - 228
• Main Authors: Qiao, Guan-Hua, Zhao, Fei, Cheng, Shuang, Luo, Min-Hua
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.06.2016
• Subjects: abnormal development; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cells, Cultured; congenital abnormalities; Cytomegalovirus - genetics; Cytomegalovirus - physiology; Cytomegalovirus Infections - virology; fetal development; fluorescent antibody technique; Genome, Viral; HCMV; Herpesviridae; Human betaherpesvirus 5; Human cytomegalovirus; Humans; Medical Microbiology; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - virology; Microbial Genetics and Genomics; Microbiology; neonates; Oncology; pathogenesis; protein synthesis; Research Article; stem cells; stromal cells; umbilical cord; Umbilical Cord - cytology; Umbilical Cord - virology; Viral Plaque Assay; Viral Proteins - biosynthesis; Viral Proteins - genetics; Viral Proteins - metabolism; virion; Virology; Virus Internalization; Virus Replication; Western blotting; 人类; 免疫荧光检测; 器官形成; 巨细胞病毒; 病毒感染; 造血干/祖细胞; 骨髓间充质干细胞; Wharton’s jelly; multipotent mesenchymal stromal cells (MSCs); susceptibility; umbilical cord; human cytomegalovirus (HCMV)

Congenital human cytomegalovirus（HCMV） infection is a leading infectious cause of birth defects.Previous studies have reported birth defects with multiple organ maldevelopment in congenital HCMV-infected neonates. Multipotent mesenchymal stromal cells（MSCs） are a group of stem/progenitor cells that...