Have changing pneumococcal vaccination programmes impacted disease in Ontario?

• Published in: Vaccine Vol. 31; no. 24; pp. 2680 - 2685
• Main Authors: Lim, Gillian H, Wormsbecker, Anne E, McGeer, Allison, Pillai, Dylan R, Gubbay, Jonathan B, Rudnick, Wallis, Low, Don E, Green, Karen, Crowcroft, Natasha S, Deeks, Shelley L
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 31.05.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Allergy and Immunology; Applied microbiology; Babies; Bacterial diseases; Bacteriology; Biological and medical sciences; burden of disease; Canada; Child; Child, Preschool; children; Confidence intervals; Disease; elderly; Epidemiology; Fundamental and applied biological sciences. Psychology; Health surveillance; Herd immunity; herds; Hospitals; Human bacterial diseases; Humans; immunity; Immunization programme impact; Incidence; Infant; Infants; Infectious diseases; Invasive pneumococcal disease; Laboratories; Male; Medical sciences; Meningitis; Microbiology; Middle Aged; Miscellaneous; monitoring; Older people; Ontario - epidemiology; people; Pneumococcal Infections - epidemiology; Pneumococcal Infections - immunology; Pneumococcal Infections - microbiology; Pneumococcal Infections - prevention & control; Pneumococcal vaccines; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - immunology; Population Surveillance; Public health; serotypes; Serotyping; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus infections; Streptococcus pneumonia; Streptococcus pneumoniae; Streptococcus pneumoniae - immunology; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Conjugate - administration & dosage; Vaccines, Conjugate - immunology; Ontario; Canada; North America; America; Ontario Canada; United States > US; Canada; Invasive pneumococcal disease; Immunization programme impact; Pneumococcal vaccines; Streptococcus pneumonia; Epidemiology; Lung disease; Immunization; Pneumonia; Respiratory disease; Vaccination; Vaccine; Streptococcus pneumoniae; Infection; Streptococcaceae; Streptococcal infection; Bacteriosis; Bacteria; Micrococcales; Pneumococcal infection
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.04.007

Highlights • Impact of Ontario's pneumococcal conjugate vaccine (PCV) programme was investigated. • Invasive pneumococcal disease due to PCV7 serotypes declined in children <5 years. • There is also some suggestion of early impact among infants of the change to PCV10. • Evidence of herd immunity and serotype replacement was observed. • Our results also demonstrate the substantial burden of disease among older adults.