MELD-XI score predict no-reflow phenomenon and short-term mortality in patient with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

• Published in: BMC cardiovascular disorders Vol. 22; no. 1; p. 113
• Main Authors: Zhang, Xin-Tao, Lin, Zhao-Rong, Zhang, Lin, Zhao, Zi-Wen, Chen, Liang-Long
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.03.2022; BioMed Central; BMC
• Subjects: Angiography; Care and treatment; Coronary Angiography - adverse effects; End Stage Liver Disease; Heart attack; Humans; Liver and renal dysfunction; Liver function tests; MELD-XI; Myocardial Infarction - complications; No-reflow phenomenon; No-Reflow Phenomenon - diagnosis; No-Reflow Phenomenon - etiology; Patient outcomes; Percutaneous coronary intervention; Percutaneous Coronary Intervention - adverse effects; Physiological aspects; Retrospective Studies; Severity of Illness Index; Short-term outcome; ST Elevation Myocardial Infarction - diagnostic imaging; ST Elevation Myocardial Infarction - therapy; ST-segment elevation myocardial infarction; China; MELD-XI; Short-term outcome; Liver and renal dysfunction; Percutaneous coronary intervention; No-reflow phenomenon; ST-segment elevation myocardial infarction
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-022-02556-2

No-reflow phenomenon (NRP) is one of the complications that mostly occur during percutaneous coronary intervention (PCI). In this study, we comprehensively examined the relationship between the model for end-stage liver disease-XI (MELD-XI) score and NRP. Moreover, we discussed whether the MELD-XI score could be considered as an accurate risk assessment score of patients with ST-segment elevation myocardial infarction (STEMI) who are candidates for PCI. This retrospective study involved 693 patients with acute STEMI and who underwent an emergency PCI. They were divided into a normal reflow group or a no-reflow group on the basis of the flow rate of post-interventional thrombolysis in myocardial infarction. Univariate, multivariate logistic regression, and Cox regression analyses were performed to identify the independent predictors of NRP in both groups. Receiver operator characteristic (ROC) curves and Kaplan-Meier curves were plotted to estimate the predictive values of the MELD-XI score. MELD-XI score was found to be an independent indicator of NRP (odds ratio: 1.247, 95% CI: 1.144-1.360, P < 0.001). Multivariate Cox regression analysis also revealed that the MELD-XI score is an independent prognostic factor for 30-day all-cause mortality (hazard ratio: 1.155, 95% CI: 1.077-1.239, P < 0.001). Moreover, according to the ROC curves, the cutoff value of the MELD-XI score to predict NRP was 9.47 (area under ROC curve: 0.739, P < 0.001). The Kaplan-Meier curves for 30-day all-cause mortality revealed lower survival rate in the group with a MELD-XI score of > 9.78 (P < 0.001). The MELD-XI score can be used to predict NRP and the 30-day prognosis in patients with STEMI who are candidates for primary PCI. It could be adopted as an inexpensive and a readily available tool for risk stratification.