Follicular helper T cells as cognate regulators of B cell immunity
Follicular helper T (TFH ) cells are a class of helper T cells specialized in the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, pregerminal center effector TFH cells promote B cell clonal expansion, antibody isotype switch, plasma cell different...
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Published in | Current opinion in immunology Vol. 21; no. 3; pp. 266 - 273 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.06.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Follicular helper T (TFH ) cells are a class of helper T cells specialized in the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, pregerminal center effector TFH cells promote B cell clonal expansion, antibody isotype switch, plasma cell differentiation, and the induction of germinal centers. By contrast, within germinal centers, TFH cells regulate the fate of antigen-specific GC B cells expressing high-affinity variant B cell receptors to promote memory B cell and long-lived plasma cell development. Recent studies unravel multiple signals controlling TFH development and functional subtypes of antigen-specific TFH cells, including memory TFH cells that accelerate memory B cell responses to antigen rechallenge in vivo. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0952-7915 1879-0372 |
DOI: | 10.1016/j.coi.2009.05.010 |