Spot urinary microalbumin concentration, metabolic syndrome and type 2 diabetes: Tehran lipid and glucose study

• Published in: BMC endocrine disorders Vol. 22; no. 1; p. 59
• Main Authors: Gaeini, Zahra, Bahadoran, Zahra, Mirmiran, Parvin, Norouzirad, Reza, Ghasemi, Asghar, Azizi, Fereidoun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.03.2022; BioMed Central; BMC
• Subjects: Adult; Albumins - metabolism; Creatinine - urine; Dextrose; Diabetes Mellitus, Type 2 - urine; Female; Glucose; Humans; Hypertension; Iran; Male; Metabolic syndrome; Metabolic Syndrome - urine; Microalbumin; Middle Aged; Type 2 diabetes; Urinary creatinine; Young Adult; Iran; Type 2 diabetes; Microalbumin; Metabolic syndrome; Urinary creatinine
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-022-00976-x

This study aimed to determine the association of urinary microalbumin concentrations with type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), and its phenotypes. The optimum cut-off values of urinary microalbumin and microalbumin-to-creatinine ratio (MCR) for predicting the chance of having T2DM and MetS were also defined. Adult men and women (n = 1192) participated in the sixth phase (2014-2017) of the Tehran Lipid and Glucose Study (TLGS), with completed data, were included in the analyses. Odds ratios (ORs) (and 95% confidence intervals (CIs)) of T2DM, MetS, and its components across tertile categories of urinary microalbumin concentrations were estimated using multivariable logistic regressions. The optimal cut-off points of urinary microalbumin and MCR were determined using the receiver operator characteristic (ROC) curve analysis. Participants' mean (±SD) age was 44.9 (±14.0) years, and 44.6% of the participants were men. The prevalence of microalbuminuria was 14.4%. Chance of having T2DM was significantly higher in the highest tertile of urinary microalbumin concentration (OR = 2.29, 95% CI = 1.43-3.67) and MCR (OR = 1.82, 95% CI = 1.15-2.89). Subjects with the highest urinary microalbumin concentration were more likely to have MetS (OR = 1.66, 95% CI = 1.17-2.35), hypertension (OR = 1.63, 95% CI = 1.16-2.30) and hyperglycemia (OR = 1.78, 95% CI = 1.24-2.56). No significant association was observed between urinary microalbumin concentrations and other components of MetS. The optimal cut-off points of urinary microalbumin for predicting the chance of having T2DM and MetS were 14.0 and 13.6 mg/L, respectively. Elevated spot urinary microalbumin, below the values defined as microalbuminuria, was associated with the chance of having T2DM and MetS.